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Inventor:
Ashizawa; Tadashi
Address:
Numazu, JP
No. of patents:
21
Patents:












Patent Number Title Of Patent Date Issued
5952355 Propenone derivatives September 14, 1999
The present invention relates to propenone derivatives represented by the following formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or YR.sup.5 (wherein Y represents S or O; and R.sup.5 repres
5717110 UCH15 compounds February 10, 1998
This invention relates to UCH15 compounds of the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a hydroxyl group.
5656736 Compound UCH9 August 12, 1997
The present invention relates to the compound UCH9 represented by the following formula: ##STR1## which has antibacterial and anti-tumor activity, and pharmaceutically acceptable salts thereof.
5334611 6-ethyl mitomycin derivatives August 2, 1994
Novel mitomycin derivatives represented by the formula (I) are obtained by introducing a substituent at the 6-position. The mitomycin derivatives of the present invention have an antitumor activity.
5256685 Mitomycin derivatives October 26, 1993
Novel mitomycin derivatives represented by the formula (I) are obtained by introducing a substituent at the 6-position. The mitomycin derivatives of the present invention have an antitumor activity.
5220026 Pyrazoloacridone derivatives June 15, 1993
Disclosed is pyrazoloacridone derivatives represented by formula (I): ##STR1## wherein: each of R.sup.1a, R.sup.1b, R.sup.1c and R.sup.1d independently represents hydrogen, lower alkyl, --(CH.sub.2).sub.p --Xwherein p represents an integer of 1 to 6, and X represents hydroxy, lower a
5218126 Halogen substituted mitomycin derivatives June 8, 1993
Disclosed are mitomycin derivatives of formula (I): ##STR1## where W represents halogen; X represents methoxy, amino or ethylenimino; Y represents hydrogen or methyl; Z represents hydrogen or methyl; and one of R.sup.1 and R.sup.2 represents carbamoyloxymethyl, and the other repr
5180825 Mitomycin derivatives January 19, 1993
Disclosed in a mitomycin derivative represented by the formula (I): ##STR1## wherein W is a heterocyclic group.
5138059 DC-89 compounds and process for their preparation August 11, 1992
Novel DC-89 compounds represented by the general formula: ##STR1## wherein X represents a single bond or --CH.sub.2 --; and when X represents a single bond, Y represents --CH.sub.2 Br or --CH.sub.2 Cl and when X represents --CH.sub.2 --, Y represents Br, are obtained by the present
5071984 DC-52 derivatives December 10, 1991
Disclosed are DC-52 derivatives represented by the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or hydroxyl, X represents hydroxyl and Y represents cyano and Z represents carboxyl or hydroxymethyl, or pharmacologically acceptable salts there
5068349 Mitomycin derivatives November 26, 1991
Novel mitomycin derivatives are characterized by a substituent on the C.sub.6 -methyl group. The mitomycin derivatives exhibit anti-tumor and antibacterial activity and have low toxicity.
4992551 DC-52 derivatives February 12, 1991
Disclosed are DC-52 derivatives represented by the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or hydroxyl, X represents hydroxyl and Y represents cyano and Z represents carboxyl or hydroxymethyl, or pharmacologically acceptable salts there
4946957 Anti-tumor DC-52 derivatives August 7, 1990
The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z r
4879386 Anti-tumor DC-52 compounds November 7, 1989
The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## ps [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and
4853385 7-N,8-N-Ethylenemitomycin 8-imines August 1, 1989
7-N,8-N-Ethylenemitomycin 8-imines represented by the formula ##STR1## wherein one of the R.sub.1 and R.sub.2 represents carbamoyloxymethyl and another represents hydrogen or both are combined together to form methylene; R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each independently re
4847387 Antibiotic compounds DC-92B and DC-92D July 11, 1989
The present invention relates to novel compounds DC-92B and DC-92D having anthraquinone moiety and represented by the following planar structural formula (I) and to a process for producing the same. These compounds can be produced by culture of a microorganism belonging to the genus
4822882 DC-52 derivatives and their antitumor use April 18, 1989
Compounds represented by the following formula or by the corresponding hydroquinone type formula: ##STR1## in which R.sup.1 and R.sup.2 are independently hydrogen, lower alkoxy, azido, amino, lower alkylamino, di-lower alkylamino, cyclic amino, lower alkylthio or unsubstituted or
4771068 Mitomycin derivatives having anti-tumor and antibacterial utility September 13, 1988
Mitomycin derivatives of the formula: ##STR1## wherein X is ##STR2## [wherein R.sub.3 is alkyl, cycloalkyl or optionally substituted phenyl; and R.sub.4 is alkyl or cycloalkyl]; n is an integer of 2 to 8; one of R.sub.1 and R.sub.2 is a hydrogen atom and the other is a ca
4748251 7-n-aminomethylenemitomycin derivative May 31, 1988
Mitomycin derivatives represented by the formula (I): ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different, and represent a hydrogen atom or a lower alkyl group; R.sub.3 and R.sub.4 mean that when R.sub.3 is a hydrogen atom, R.sub.4 represents --CH.sub.2 OCONH.sub.2 or
4691024 New mitomycin derivatives, preparation thereof and pharmaceutical compositions containing them September 1, 1987
The present invention provides new mitomycin derivatives of general formula (I) ##STR1## [wherein Y and Z, which may be the same or different, each represents a hydrogen atom or a methyl group; represents .alpha. or .beta. bonding and X represents a group of formula (II) ##S
4593097 Phenazine carboxylic acid derivatives and a process for production thereof June 3, 1986
Phenazine compounds represented by the formula: ##STR1## wherein R is a hydrogen atom, an unsubstituted or substituted lower alkanoyl group, or an unsubstituted or substituted arylcarbonyl group have antibacterial and anti-tumor activities.Some of these compounds are produced by incu










 
 
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