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Inventor:
Angibaud; Patrick Rene
Address:
Fontaine-Bellenger, FR
No. of patents:
41
Patents:












Patent Number Title Of Patent Date Issued
8299256 Quinolinone derivatives as PARP and TANK inhibitors October 30, 2012
The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, n, m and X have defined meanings
8268833 Inhibitors of histone deacetylase September 18, 2012
This invention comprises the novel compounds of formula (I) ##STR00001## wherein n, t, R.sup.1, R.sup.2, R.sup.3, R.sup.4, L, Q, X, Y, Z and ##STR00002## have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing the
8193205 Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase June 5, 2012
This invention comprises the novel compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
8168644 Quinazolinone derivatives as tubulin polymerization inhibitors May 1, 2012
The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization as well as pharmaceutical compositions comprising said compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, n, m and X have defin
8163765 Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase April 24, 2012
This invention comprises the novel compounds of formula (1) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a
8163733 Sulfonylamino-derivatives as novel inhibitors of histone deacetylase April 24, 2012
This invention comprises the novel compounds of formula (I) ##STR00001## wherein n, m, t, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, L, Q, X, Y, Z and ##STR00002## have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions conta
8138198 Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone de March 20, 2012
This invention comprises the novel compounds of formula (I) wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine. ##STR00001##
8119650 Aminophenyl derivatives as novel inhibitors of histone deacetylase February 21, 2012
This invention comprises the novel compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions
8114876 Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase February 14, 2012
This invention comprises the novel compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
8101616 Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase January 24, 2012
This invention comprises the novel compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions contai
7947830 Substituted propenyl piperazine derivatives as novel inhibitors of histone deacetylase May 24, 2011
This invention comprises the novel compounds of formula (I) wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine. ##STR00001##
7943635 Benzylimidazolyl substituted 2-quinoline and quinazoline derivatives for use as farnesyl transfe May 17, 2011
This invention comprises the novel compounds of formula (I) ##STR00001## wherein r, t, Y.sup.1, Y.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.6 and R.sup.7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and
7888360 Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase February 15, 2011
This invention comprises the novel compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, X, Y and Z have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
7834025 Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase November 16, 2010
This invention comprises the novel compounds of formula (I) wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine. ##STR
7834011 Heterocyclylalkyl derivatives as novel inhibitors of histone deacetylase November 16, 2010
This invention comprises the novel compounds of formula (I) ##STR00001## wherein R.sup.1, T, X, Y, A, n, m and p have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
7816363 Inhibitors of histone deacetylase October 19, 2010
This invention comprises the novel compounds of formula (I) wherein n, t, R.sup.1, R.sup.2, R.sup.3, R.sup.4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
7767679 Sulfonylamino-derivatives as novel inhibitors of histone deacetylase August 3, 2010
This invention comprises the novel compounds of formula (I) ##STR00001## wherein n, m, t, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, L, Q, X, Y, Z and ##STR00002## have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containi
7655654 Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked February 2, 2010
This invention comprises the novel compounds of formula (I) ##STR00001## wherein r, s, t, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a
7615553 Inhibitors of histone deacetylase November 10, 2009
This invention comprises the novel compounds of formula (I) wherein n, R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine. ##ST
7572916 Diastereoselective synthesis process with 6-bromo-4-(3-chlorophenyl)-2-methoxy-quinoline August 11, 2009
A diastereoselective synthesis process for the preparation of (R)-(+)-6-[amino(4chlorophenyl)(1-methyl-1H-imidazol-5-yl) methyl]-4-(3-chlorophenyl)-1-methyl2(1H)-quinolinone which comprises the preparation of a compound of formula (XVII): and the stereochemically isomeric forms there
7541369 Amino-derivatives as novel inhibitors of histone deacetylase June 2, 2009
This invention comprises the novel compounds of formula (I) ##STR00001## wherein n, m, t, R.sup.1, R.sup.2, L, Q, X, Y, Z and ##STR00002## have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use a
7524961 Diastereoselective addition of lithiated N-methylimidazole on sulfinimines April 28, 2009
A diastereoselective synthesis process for the preparation of (R)-(+)-6-[amino(4-chlorophenyl) (1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2 (1H)-quinolinone which comprises the preparation of a compound of formula (VIII) ##STR00001## and the stereochemically isom
7511138 Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked March 31, 2009
This invention comprises the novel compounds of formula (I) wherein r, s, t, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicine. #
7456287 Diastereoselective synthesis process for the preparation of imidazole compounds November 25, 2008
A diastereoselective synthesis process for the preparation of an enantiomer of 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophe- nyl)-1-methyl-2(1H)-quinolinone which comprises the conversion of (.+-.)-6-[chloro(4-chlomphenyl)(1-methyl-1H-imidazol-5-yl)methyl]
7408063 1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transfe August 5, 2008
This invention comprises the novel compounds of formula (I) ##STR00001## wherein r, s, A, X, Y.sup.1, Y.sup.2, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use
7241777 Benzylimidazolyl substituted 2-quinoline and quinazoline derivatives for use as farnesyl transfe July 10, 2007
This invention comprises the novel compounds of formula (I) ##STR00001## wherein r, t, Y.sup.1, Y.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.5, R.sup.6and R.sup.7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and
7196094 Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives March 27, 2007
This invention comprises the novel compounds of formula (I) ##STR00001## wherein r, t, Y.sup.1--Y.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing
7173040 Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinaz February 6, 2007
This invention comprises the compounds of formula (I): ##STR00001## wherein r, s, t, Y.sup.1 Y.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing th
7153958 Farnesyl transferase inhibiting benzoheterocyclic derivatives December 26, 2006
This invention comprises the novel compounds of formula (I) ##STR00001## wherein r, s, t, X, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and
7129356 Farnesyl transferase inhibiting 4-substituted quinoline and quinazoline derivatives October 31, 2006
This invention comprises the novel compounds of formula (I) ##STR00001## wherein r, s, t, Y.sup.1, Y.sup.2, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions cont
7053105 Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase in May 30, 2006
This invention comprises the novel compounds of formula (I) wherein r, s, t, Y.sup.1--Y.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.7 have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use
6914066 1,2-annelated quinoline derivatives July 5, 2005
This invention concerns compounds of formula ##STR1##the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein .dbd.X.sup.1 --X.sup.2 --X.sup.3 -- is a trivalent radical,; >Y.sup.1 --Y.sup.2 -- is a trivalent radical; r and s are
6458800 1,2-annelated quinoline derivatives October 1, 2002
This invention concerns compounds of formula ##STR1##the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein .dbd.X.sup.1 --X.sup.2 --X.sup.3 -- is a trivalent radical,; >Y.sup.1 --Y.sup.2 -- is a trivalent radical; r and s are
6444812 Intermediate compounds in the preparation of farnnesyl transferase inhibiting 1,8-annelated quin September 3, 2002
This invention concerns intermediates in the preparation of compounds of formula ##STR1##the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; --A-- is a bivalen
6420387 Farnesyl protein transferase inhibiting (imidazol-5-yl) methyl-2-quinolinone derivatives July 16, 2002
This invention comprises the novel compounds of formula (I) ##STR1##wherein the dotted line represents an optional bond; X is oxygen or sulfur; R.sup.1 is hydrogen, C.sub.1-12 alkyl, Ar.sup.1, Ar.sup.2 C.sub.1-6 alkyl, quinolinylC.sub.1-6 alkyl, pyridylC.sub.1-6 alkyl, hydroxyC.sub.1-6 a
6358961 Farnesyltransferase inhibiting quinazolinones March 19, 2002
This invention concerns compounds of formula ##STR1##the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; R.sub.1 and R.sup.2 each independently are hydrogen, h
6187786 Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-l February 13, 2001
This invention concerns compounds of formula ##STR1##the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; --A-- is a bivalent radical of formula; R.sup.1 and R.
6177432 Farnesyltransferase inhibiting quinazolinones January 23, 2001
This invention concerns compounds of formula ##STR1##the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; R.sup.1 and R.sup.2 each independently are hydrogen, h
6169096 Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quinolinone derivatives January 2, 2001
This invention comprises the novel compounds of formula (I) ##STR1##wherein the dotted line represents an optional bond; X is oxygen or sulfur; R.sup.1 is hydrogen, C.sub.1-12 alkyl, Ar.sup.1, Ar.sup.2 C.sub.1-6 alkyl, quinolinylC.sub.1-6 alkyl, pyridylC.sub.1-6 alkyl, hydroxyC.sub.1-6 a
6037350 Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quionlinone derivatives March 14, 2000
This invention comprises the novel compounds of formula (I) ##STR1## wherein the dotted line represents an optional bond; X is oxygen or sulfur; R.sup.1 is hydrogen, C.sub.1-12 alkyl, Ar.sup.1, Ar.sup.2 C.sub.1-6 alkyl, quinolinylC.sub.1-6 alkyl, pyridylC.sub.1-6 alkyl, hydroxyC.
5968952 Farnesyl transferase inhibiting 2-quinolone derivatives October 19, 1999
The present invention is concerned with compounds of formula (I), ##STR1## the stereoisomeric forms thereof and the pharmaceutically acceptable acid or base addition salts thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; R.sup.1 is hydrogen, C.sub.










 
 
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