| Patent Number |
Title Of Patent |
Date Issued |
| 7553619 |
Detection method using dissociated rolling circle amplification |
June 30, 2009 |
| Disclosed are compositions and methods for detecting small quantities of analytes such as proteins and peptides. The method involves associating a DNA circle with the analyte and subsequent release and rolling circle replication of the circular DNA molecule. In the method, an amplificati |
| 6977153 |
Rolling circle amplification of RNA |
December 20, 2005 |
| Disclosed are compositions and methods for amplification of RNA molecules. The disclosed method involves synthesizing first strand cDNA molecules from RNA molecules, circularizing the first strand cDNA molecules and replicating the circularized first strand cDNA molecules using rolling |
| 6777183 |
Process for allele discrimination utilizing primer extension |
August 17, 2004 |
| Disclosed are methods for allele discrimination involving the use of rolling circle amplification (RCA) coupled with primer extension and utilizing exonuclease deficient polymerases to distinguish matched and unmated single nucleotide sites, such as in the case of a single nucleotide |
| 6573051 |
Open circle probes with intramolecular stem structures |
June 3, 2003 |
| Disclosed are compositions and methods for reducing or eliminating generation of unwanted, undesirable, or non-specific amplification products in nucleic acid amplification reactions, such as rolling circle amplification. One form of composition is an open circle probe that can form |
| 6498023 |
Generation of single-strand circular DNA from linear self-annealing segments |
December 24, 2002 |
| The present invention provides a method for the rapid simultaneous production of a plurality of single-stranded DNA circles having a predetermined size and nucleotide sequence using pre-designed hairpin oligonucleotides containing complementary sequences for directing ligation to for |
