Resources Contact Us Home
On-chip polarimetry for high-throughput screening of nanoliter and smaller sample volumes

Image Number 5 for United States Patent #8134707.

A polarimetry technique for measuring optical activity that is particularly suited for high throughput screening employs a chip or substrate (22) having one or more microfluidic channels (26) formed therein. A polarized laser beam (14) is directed onto optically active samples that are disposed in the channels. The incident laser beam interacts with the optically active molecules in the sample, which slightly alter the polarization of the laser beam as it passes multiple times through the sample. Interference fringe patterns (28) are generated by the interaction of the laser beam with the sample and the channel walls. A photodetector (34) is positioned to receive the interference fringe patterns and generate an output signal that is input to a computer or other analyzer (38) for analyzing the signal and determining the rotation of plane polarized light by optically active material in the channel from polarization rotation calculations.

  Recently Added Patents
System and method for monitoring network activity
Method and apparatus for rebuilding data in a dispersed data storage network
Defensin polynucleotides and methods of use
Method and apparatus for controlling cardiac resynchronization therapy using cardiac impedance
Modified binding proteins inhibiting the VEGF-A receptor interaction
Generator with a segmented stator
Family of pain producing substances and methods to produce novel analgesic drugs
  Randomly Featured Patents
High surface area lean NOx catalyst
Wall-mounted ticket booth
Method and apparatus for changing the perspective view of a three-dimensional object image displayed on a display screen
Optical memory system providing track following
Power semiconductor device
Process for the treatment of aluminum based substrates for the purpose of anodic oxidation, bath used in said process and concentrate to prepare the bath
Sports training device for head and neck movement
Piercing member protection device
Database system shared by multiple client apparatuses, data renewal method, and application to character processors