Resources Contact Us Home
On-chip polarimetry for high-throughput screening of nanoliter and smaller sample volumes

Image Number 10 for United States Patent #8134707.

A polarimetry technique for measuring optical activity that is particularly suited for high throughput screening employs a chip or substrate (22) having one or more microfluidic channels (26) formed therein. A polarized laser beam (14) is directed onto optically active samples that are disposed in the channels. The incident laser beam interacts with the optically active molecules in the sample, which slightly alter the polarization of the laser beam as it passes multiple times through the sample. Interference fringe patterns (28) are generated by the interaction of the laser beam with the sample and the channel walls. A photodetector (34) is positioned to receive the interference fringe patterns and generate an output signal that is input to a computer or other analyzer (38) for analyzing the signal and determining the rotation of plane polarized light by optically active material in the channel from polarization rotation calculations.

  Recently Added Patents
Method and system for providing intelligent call rejection and call rollover in a data network
Autonomous downlink code selection for femto cells
Fingerprinting apparatus, system, and method
Systems and methods for universal enhanced log-in, identity document verification and dedicated survey participation
Voltage level shift circuits and methods
Dynamic allocation of access channels based on access channel occupancy in a cellular wireless communication system
Inspection systems and methods for detecting defects on extreme ultraviolet mask blanks
  Randomly Featured Patents
Outer rotor motor
Signal repeater and switching device, method of detecting connecting relation between signal repeater and switching device and communication system
Optical media converter system
Conveying device for feeding sheet-like products to a processing machine for printed products
Electrophotographic image forming apparatus
Imaging device for printing form
Double tapered article
Portable battery-powered tool
Dynamic digital to synchro converter
Door knob construction