Resources Contact Us Home
Oligoadenylate synthetase (OAS)

Image Number 2 for United States Patent #8133710.

The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention.

  Recently Added Patents
ZNF217 a new prognostic and predictive biomarker of recurrent invasive and metastatic phenotypes in breast cancer
Knife grip
Masking method and apparatus
Synchronization of sound generated in binaural hearing system
Eye therapy system
Managing delivery of application server content
Cordless hand blender
  Randomly Featured Patents
Method for maintenance of an array of bolometer-type detectors
Surface modified nanoparticle and method of preparing same
Electrostatic imaging member for contact charging and imaging processes thereof
Opposite direction transfer device
Portable staple holder
Multi-beam emitting device and light scanning unit employing the same
Method for generation of bio-gas
Gelatin coated medicament and process for making same
Projection type display apparatus
Lens cleaning devices