Resources Contact Us Home
Oligoadenylate synthetase (OAS)

Image Number 2 for United States Patent #8133710.

The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention.

  Recently Added Patents
High power insulated gate bipolar transistors
Navigation system and navigation apparatus
Method and arrangement for controlling semiconductor component
Bacterial superantigen vaccines
Distributed image acquisition, storage, and backup system
Context-based adaptive binary arithmetic coding engine
Redundant parallel operation of motor vehicle electrical system generators
  Randomly Featured Patents
Streak camera tube
Process for purifying gases loaded in particular with chemical residues
Squeeze bottle apparatus with force multiplying pistons
Stylette end cap
Laser light irradiation apparatus and laser light irradiation method
Continuous transverse stub element devices and methods of making same
Therapeutic limb manipulator
Coating powders on the basis of thermoplastic polyesters
Image recorder
Method and system for extracting metal from glass waste