Resources Contact Us Home
Oligoadenylate synthetase (OAS)

Image Number 2 for United States Patent #8133710.

The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention.

  Recently Added Patents
Algorithm for color corrected analog dimming in multi-color LED system
Systems and methods for programming an RFID reader
Quinoid thiophene organic photoelectric material, preparation method thereof and application thereof
System, method, and computer program product for determining whether an electronic mail message is compliant with an etiquette policy
Multi-contoured yoga support
Authenticating and off-loading IPTV operations from mobile devices to fixed rendering viewing devices
Laser processing a multi-device panel
  Randomly Featured Patents
Polarized electrode and electric double-layer capacitor
Robot mounter for mounting core slider
Cap-lining machine
Process for the preparation of chlorothiazole derivatives
Digital signal processing apparatus
Latex compositions comprising pozzolan and/or cement kiln dust and methods of use
Ink jet recording apparatus and ink suction method of the recording head
Multi-chamber workpiece processing
Electronic ticket vending system