Resources Contact Us Home
Oligoadenylate synthetase (OAS)

Image Number 2 for United States Patent #8133710.

The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention.

  Recently Added Patents
Shield for vacuum circuit breaker
High-efficiency preambles for communications systems over pseudo-stationary communication channels
Preparation and use of meristematic cells belonging to the Dendrobium phalaenopsis, Ansellia, Polyrrhiza, Vanilla, Cattleya and Vanda genera with high content of phenylpropanoids, hydrosoluble
Method of hydrothermal liquid phase sintering of ceramic materials and products derived therefrom
Use of Lactobacillus for liver protection
Method for fabricating solar cell
Information processing device and display control method
  Randomly Featured Patents
Coupling element connecting two parallel, spaced shafts for varying their position relative to one another
Organic compounds
Walk-behind self-propelled broom sweeper
Self-ejecting cigar core cutter
Optical modulators and a method for modulating light
Perforated composites for joining of metallic and composite materials
Semiconductor device with a metal line and method of forming the same
Antigens and antibodies of catecholamines
Virtual skywriting
High wattage insulated ceiling lighting fixture