Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Oligoadenylate synthetase (OAS)










Image Number 2 for United States Patent #8133710.

The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention.








 
 
  Recently Added Patents
Imaging apparatus for calculating a histogram to adjust color balance
Method of making a CIG target by cold spraying
Detachably integrated battery charger for mobile cell phones and like devices
Method of transmitting data using spatial multiplexing
Digital photographing apparatus and control method for evaluating validity of an auto-focus operation
Isolated SCR ESD device
Polishing composition
  Randomly Featured Patents
Processing apparatus with wall conditioning shuttles
Optical fiber switch using nematic crystal to switch unpolarized optical signals
Embolic protection device
Liquid crystal display heating system
1-2 Shift valve for an automatic transmission
Fuel injection pump
Methods of processing compositions containing microparticles
Cosmetic composition containing a polymer blend
Network linking method using information embedded in data objects that have inherent noise
Tamper indicating closure system