Resources Contact Us Home
Oligoadenylate synthetase (OAS)

Image Number 2 for United States Patent #8133710.

The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention.

  Recently Added Patents
Light emitting device
Method and computed tomography device and data storage medium for performing a dynamic CT examination on a patient
Stock analysis method, computer program product, and computer-readable recording medium
Using network labels without standard-defined syntax and semantics
Solid-state image sensing apparatus and electronic apparatus
Therapeutic rinse in a self-heating package
Accessory sleeve
  Randomly Featured Patents
Vacuum processing apparatus
Mobile terminal, radio communication apparatus and radio communication method
Digital data recording and decoding
Resealable tamper-evident container assembly and lid
Turbine blade with spar and shell
Human trk receptors and neurotrophic factor inhibitors
Method and apparatus for direct spectrophotometric measurements in unaltered whole blood
Ink-jet printing system
Sheet glass working machine