Resources Contact Us Home
Oligoadenylate synthetase (OAS)

Image Number 2 for United States Patent #8133710.

The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, improved antiviral activity, improved enzymatic activity, or absent enzymatic activity. The pharmaceutical compositions have improved drug properties and retain or have enhanced antiviral activity relative to their native forms. The pharmaceutical compositions further include chemically modified oligoadenylate synthetases, such chemical modifications being designed to increase serum stability and reduce immunogenicity in vivo. Such chemical modifications further increase drug stability and manufacturability in vitro. Compositions composed of more than ninety novel modifications are described. Also described are antibodies to polypeptides of the invention.

  Recently Added Patents
Cellulose ester compositions having low birefringence and films made therefrom
Vending machine
Key management system
Wireless communication system, wireless communication device, wireless communication method, and program
Gas flow indicator
Battery comprising circuitry for charge and discharge control, and method of operating a battery
  Randomly Featured Patents
Solar panel supporting system
Controlling on-screen displays
Method and apparatus for production of tubing
Method of manufacturing optical fiber base material
Self-pumping hydropneumatic shock absorber
Pendulum sight
System and method for automatically varying a volume of a liquid held by a toilet receptacle
Backlight assembly providing light in multiple directions and display device employing the same
High affinity L-proline transporter polypeptides; antibodies and immunoassays specific for them
Plant protector apparatus and method