Resources Contact Us Home
Cholesterol loaded insect cell membranes as test proteins

Image Number 18 for United States Patent #8129197.

The invention provides for a novel cholesterol loaded insect cell membrane preparation having an increased cholesterol level as compared to physiological cholesterol levels of insect cell membranes or to control insect cell membrane preparations without cholesterol loading, wherein said cholesterol loaded membrane preparation comprises an ABC transporter protein having an increased substrate transport activity due to increased cholesterol level of the membrane. The invention also relates to reagent kits comprising the preparations of the invention. The invention also relates to methods for manufacturing said preparations and methods for measuring any type of activity of the ABC transporters present in the cholesterol loaded membranes as well as studying or testing compounds and interaction of compounds and ABC transporters, in this assay systems. The invention also provides for a test system useful for testing whether ABC transporter proteins can be activated by cholesterol in an insect cell membrane.

  Recently Added Patents
Input device with photodetector pairs
Light barrier and method for detecting objects
Myoglobin blooming agents, films, packages and methods for packaging
Coated article and method for making the same
Compact multi-functional scanning apparatus with retractable flatbed scanner
Vapor phase decarbonylation process
Nanocatalysts structure, process for the preparation and use thereof
  Randomly Featured Patents
Methods and structure for assuring correct data order in SATA transmissions over a SAS wide port
Eye axial length measurement apparatus
Apparatus for pumping a slurry
Disk drive partially autonomous preamplifier for write current parameters
Curing fibrous mineral material
Automatic static load testing for piles
Curing agent for epoxy resin
Dielectric ceramic and monolithic ceramic capacitor including same
Anaesthetic pharmaceutical composition comprising a general anaesthetic and selegiline
Aminoalkyl-substituted imidazoles