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Mutants of cholesterol-dependent cytolysins and uses thereof

Image Number 9 for United States Patent #8128939.

Mutants of cholesterol-dependent cytolysins comprising at least one amino acid substitution in at least one of Loop 1, Loop 2, or Loop 3 of Domain 4, nucleic acids encoding such polypeptide mutants, and compositions and vaccines comprising such polypeptide mutants.

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