Resources Contact Us Home
Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety

Image Number 13 for United States Patent #8119616.

The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a .beta.-cyclodextrin or a derivative thereof. The quinazolines have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

  Recently Added Patents
Treatment of celiac disease with IgA
System, apparatus, and method for fast startup of USB devices
Disk-based storage device having read channel memory that is selectively accessible to disk controller
Information repository search system
Method and system for updating device management application meter read logic
Semiconductor device and method for fabricating the same
Fuel cell and a method of manufacturing a fuel cell
  Randomly Featured Patents
Liquid crystal display having wide viewing angle
Process for preparing calcium silicate shaped product
Electric field sensor
Method and apparatus for transmitting data frame using channel bonding in wireless LAN
Off-line supercritical fluid extraction collection system
Camp factor of streptococcus uberis
Print receptive articles
Self-righting post and method for the assembly and use thereof
Seat with adjustable back rest
Saw blade package and carry case