Resources Contact Us Home
Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety

Image Number 13 for United States Patent #8119616.

The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a .beta.-cyclodextrin or a derivative thereof. The quinazolines have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

  Recently Added Patents
Real-time virtual endoscopy
Method of manufacturing acrylic film, and acrylic film
Information storage medium, reproducing method, and recording method
Mobile interactive kiosk method
Wavelength and power scalable waveguiding-based infrared laser system
Dose escalation enzyme replacement therapy for treating acid sphingomyelinase deficiency
  Randomly Featured Patents
Media data encoding device
Method and apparatus for tracking the motion of an imaging member with a line writing device using a rational electronic gearbox
Envelope addressing format feature for electronic typewriters
Color inkjet printer
Directed auto-refresh synchronization
Method and apparatus for finding objects within a visual display
Method for performing carrier management procedure in a multi-carrier supported wideband wireless communication system and apparatus for the same
Fuse circuit with controlled fuse burn out and method thereof
Memory cell insensitive to collisions of heavy ions
Methods and systems for adaptive dither pattern application