Resources Contact Us Home
Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety

Image Number 13 for United States Patent #8119616.

The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a .beta.-cyclodextrin or a derivative thereof. The quinazolines have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

  Recently Added Patents
Extreme ultraviolet light source device and method for generating extreme ultraviolet light
Packet bundling at the PDCP layer
Protection circuit, substrate for electro-optical device, electro-optical device, electrophoretic display device, electronic apparatus, and manufacturing method of electro-optical device
Resin composition and display device using the same
Nanofibers containing latent reactive groups
Methods and apparatuses for configuring and operating graphics processing units
Techniques for image segment accumulation in document rendering
  Randomly Featured Patents
Device for securing a firearm, as well as for securing and/or storing objects
Apparatus for recording video signal through frequency modulation with variable clipping level
Three dimensional NAND memory
Low noise spacecraft body rate sensing arrangement for attitude control
Processes for preparing valve metal powders, powders prepared thereby and uses therefor
Rotary device for stunt bicycles
Deck support bracket
Process for producing a high-purity oxygenic compound and lubricating oil
Client-server based remote locator device
Wheeled board security rack