Resources Contact Us Home
Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety

Image Number 13 for United States Patent #8119616.

The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a .beta.-cyclodextrin or a derivative thereof. The quinazolines have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

  Recently Added Patents
Automated hotfix handling model
Low powered activation arrangement and method thereof
Aircraft drive
Depth estimation apparatus and method
Wide viewing angle indicators for network devices
Autonomous primary-mirror synchronized reset
Monitoring of undesirable fluid ingress into subsea control modules
  Randomly Featured Patents
Novel epoxy curing system
Method of applying a slider device to an open closure mechanism on a resealable bag
Obtaining road traffic condition data from mobile data sources
Densely packed telecommunications equipment enclosure
Method for fabricating semiconductor devices having silicided electrodes
System and method for providing packet proxy services across virtual private networks
Lockable turnbuckle
Removable maintenance port with method for rehabilitating manhole
Dental handpiece holder and treatment assembly by use thereof
Liquid chemical delivery system