Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety










Image Number 13 for United States Patent #8119616.

The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a .beta.-cyclodextrin or a derivative thereof. The quinazolines have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.








 
 
  Recently Added Patents
Systems and methods for sensing external magnetic fields in implantable medical devices
Integrated emergency medical database system
Crystalline solvates of 6-(piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride
Clostridium chauvoei polypeptide, DNA encoding the polypeptide and a vaccine comprising the polypeptide
Therapeutic vitamin D sun-protecting formulations and methods for their use
Protein purification
Etch resistant clearcoat
  Randomly Featured Patents
Investment casting
Multiple-core optical fiber with coupling between the cores
Adjustable vehicle seat mounting
Communication configurator and method for implementing same
Rotary screw compressor with slide valve and slide stop guidance bushings
Sensor element array and method for signal or image processing
Method for manufacturing SOI substrate and semiconductor device
Spark plug having tapered ground electrode
Method for dynamically assessing petroleum reservoir competency and increasing production and recovery through asymmetric analysis of performance metrics
Solid state heater assembly, heater subassembly and methods of assembly