Resources Contact Us Home
Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety

Image Number 13 for United States Patent #8119616.

The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a .beta.-cyclodextrin or a derivative thereof. The quinazolines have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

  Recently Added Patents
Composite materials comprising aggregate and an elastomeric composition
Leaky wave mode solar receiver
Method and apparatus for communications
Systems and methods for image stream processing
Presenting a link to a user
Battery module
Device and method for controlling brightness of organic light emitting diode display
  Randomly Featured Patents
Processing system operable in various execution environments
Image forming apparatus, method of controlling the same, and program
Dynamically reconfigurable signal processing circuit, pattern recognition apparatus, and image processing apparatus
Vacuum ionization gauge with high sensitivity
Phase reading fiber optic interferometer
Adaptive reader-writer lock
High payload six-axis load sensor
Dishwasher control panel
Apparatus for treating recurrent ear infections
Image capture and storage techniques in association with optical mark reading