Resources Contact Us Home
Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety

Image Number 13 for United States Patent #8119616.

The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a .beta.-cyclodextrin or a derivative thereof. The quinazolines have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

  Recently Added Patents
Image sensing apparatus and method of controlling the image sensing apparatus
2,2'-binaphthalene ester chiral dopants for cholesteric liquid crystal displays
Perfume bottle
Predictive time entry for workforce management systems
Hybrid fiber constructions to mitigate creep in composites
Facility to reuse paper
  Randomly Featured Patents
CE to RRO cancellation for sled control
Flow box with two deflectors
Method of forming finned semiconductor devices with trench isolation
Vehicular seats
Hands-free telephone
Drive unit for a distributor and a fuel pump
Initialize control system in a cash processing system
Miter gauge
AC system utilizing condensate water to precool hot gas
Acoustic surface-wave bandpass filter