Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety










Image Number 13 for United States Patent #8119616.

The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a .beta.-cyclodextrin or a derivative thereof. The quinazolines have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.








 
 
  Recently Added Patents
Method of creating animatable digital clone from multi-view images
5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases
Magnetic memory element, driving method for same, and nonvolatile storage device
Process for the production of alcohol
Automated synchronization of design features in disparate code components using type differencing
Liquid crystal display panel
Image forming apparatus, control method, and storage medium
  Randomly Featured Patents
Heat exchanger barrier ribbon with polymeric tubes
Housekeeping power supply for electronically controlled loads
Unitized seismic bracket with strength bend
Method for automatic detection of display sharing and alert generation in instant messaging
Check valve with oversized bill
Porous filter media with vent
Method for producing shoes and a shoe obtained by this method
Color adjusting method
Apparatus for manufacturing textile coils having predetermined thread length
Oil retrieving structure for a compressor