Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Methods and compositions for diagnosis and treatment of B cell chronic lymphocytic leukemia










Image Number 13 for United States Patent #8119340.

Provided are isolated and purified preparations of a combination of a light chain antibody gene and a heavy chain antibody gene, where the light chain and heavy chain antibody genes are the same among more than one patient with B cell chronic lymphocytic leukemia (B-CLL). Vectors comprising those genes and cells comprising those vectors are also provided, as are isolated and purified antibodies encoded by the antibody genes. Anti-idiotype antibodies, peptides, and aptamers that bind to the antigen-binding region of an antibody encoded by the antibody genes are additionally provided, as are multimeric molecules comprising multiple binding sites that bind to the antigen-binding region of an antibody encoded by the antibody genes. Methods of determining whether a patient with B cell chronic lymphocytic leukemia (B-CLL) has a form of B-CLL that is susceptible to treatment directed to eliminating idiotype specific B cell receptor-bearing B-CLL cells are also provided, as are methods of following the progression of treatment of B-CLL in the patient. Additionally, methods of treating a patient having B-CLL are provided, as are methods of identifying a therapeutic agent for B-CLL.








 
 
  Recently Added Patents
Sample chamber for laser ablation inductively coupled plasma mass spectroscopy
Plants and seeds of hybrid corn variety CH514730
Imaging device
Nanoparticles in a flash memory using chaperonin proteins
Carbon dioxide capture system and methods of capturing carbon dioxide
Method for repairing or replacing damaged tissue
Clostridium chauvoei polypeptide, DNA encoding the polypeptide and a vaccine comprising the polypeptide
  Randomly Featured Patents
Exposure time reproducing device
Aerodynamic rotor blade of composite material fabricated in one cure cycle
Method for bonding wafers to produce stacked integrated circuits
Seating unit
Joint-pack integrated spacers
Wide area navigation for a robot scrubber
Gaming device having multiple displays
Using a rights template to obtain a signed rights label (SRL) for digital content in a digital rights management system
Juicer
Light-transmitting pipe