Resources Contact Us Home
Human prostate cell lines in cancer treatment

Image Number 17 for United States Patent #8097244.

Combinations of cell lines are provided for allogeneic immunotherapy agents in the treatment of cancer. Cancer vaccines generally have been limited to the use of cells that contain at least some tumor specific antigens ("TSAs") and/or tumor associated antigens ("TAAs") having shared identity with antigens in a targeted tumor. In such cases, tumor cells often are utilized as a starting point on the premise that only tumor cells will contain TSAs or TAAs or relevance, and the tissue origins of the cells are matched to the tumor site in patients. A primary aspect of the invention is the use of immortalised normal, non-malignant cells, in combination with primary and/or metastatic tumor cells, as the basis of an allogeneic cell cancer vaccine. Normal cells do not posses TSAs or relevant concentrations of TAAs and hence it is surprising that normal cells are effective as anti-cancer vaccines when administered in combination with primary and/or metastatic tumor cells. More surprisingly, a three way combination of cells obtained from metastasized cells, non metastasized tumor and cells from a normal cell line provided good therapy. For prostate cancer, for example, a vaccine may be based on one or a combination of different immortalized normal cell lines derived from the prostate according to parameters described herein. The cell lines may be lethally irradiated with, for example, gamma irradiation at 50-300 Gy to ensure that they are replication incompetent prior to use.

  Recently Added Patents
Methods, systems, and products for monitoring service usage
Automatic back cleaner and track system
Rolling mill stand and related rolling mill for longitudinally rolling rod-shaped bodies
Speaker grill
Stereoscopic images generated by adding content to alternate eye images for retinal rivalry
Arrangement of at least one personal service unit in a vehicle
Hinged ankle brace
  Randomly Featured Patents
System and method for making nanoparticles using atmospheric-pressure plasma microreactor
Busway weatherproof housing
Network selection in a WLAN
Foldable tool kit
System and method of using a side-mounted interferometer to acquire position information
Long-life multi-stage ferrofluid seals incorporating a ferrofluid reservoir
Hydroelectric power optimization service
Optical data storage media
Muffler converter
Semi-solid cylindrical container and dispenser