Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Human prostate cell lines in cancer treatment










Image Number 17 for United States Patent #8097244.

Combinations of cell lines are provided for allogeneic immunotherapy agents in the treatment of cancer. Cancer vaccines generally have been limited to the use of cells that contain at least some tumor specific antigens ("TSAs") and/or tumor associated antigens ("TAAs") having shared identity with antigens in a targeted tumor. In such cases, tumor cells often are utilized as a starting point on the premise that only tumor cells will contain TSAs or TAAs or relevance, and the tissue origins of the cells are matched to the tumor site in patients. A primary aspect of the invention is the use of immortalised normal, non-malignant cells, in combination with primary and/or metastatic tumor cells, as the basis of an allogeneic cell cancer vaccine. Normal cells do not posses TSAs or relevant concentrations of TAAs and hence it is surprising that normal cells are effective as anti-cancer vaccines when administered in combination with primary and/or metastatic tumor cells. More surprisingly, a three way combination of cells obtained from metastasized cells, non metastasized tumor and cells from a normal cell line provided good therapy. For prostate cancer, for example, a vaccine may be based on one or a combination of different immortalized normal cell lines derived from the prostate according to parameters described herein. The cell lines may be lethally irradiated with, for example, gamma irradiation at 50-300 Gy to ensure that they are replication incompetent prior to use.








 
 
  Recently Added Patents
Method and apparatus for representing sensory effects and computer readable recording medium storing user sensory preference metadata
Polishing composition
Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents
Lock monitoring
Monitoring of undesirable fluid ingress into subsea control modules
Accelerator for a read-channel design and simulation tool
High porosity ceramic honeycomb article containing rare earth oxide and method of manufacturing same
  Randomly Featured Patents
Stimulated Brillouin scattered (SBS) tuned laser
Method for transmitting/receiving data with transfer obligation delegated in WSN
System and method for optical communication using polarization filtering
Electric solid state device and method for manufacturing the device
Quantifying the impact of network latency on the end-to-end response time of distributed applications
Non-freeze wall hydrant
Mobile phone
Atomizer nozzle assembly
Cobalt silicide structure for improving gate oxide integrity and method for fabricating same
Chair table