Resources Contact Us Home
Human prostate cell lines in cancer treatment

Image Number 17 for United States Patent #8097244.

Combinations of cell lines are provided for allogeneic immunotherapy agents in the treatment of cancer. Cancer vaccines generally have been limited to the use of cells that contain at least some tumor specific antigens ("TSAs") and/or tumor associated antigens ("TAAs") having shared identity with antigens in a targeted tumor. In such cases, tumor cells often are utilized as a starting point on the premise that only tumor cells will contain TSAs or TAAs or relevance, and the tissue origins of the cells are matched to the tumor site in patients. A primary aspect of the invention is the use of immortalised normal, non-malignant cells, in combination with primary and/or metastatic tumor cells, as the basis of an allogeneic cell cancer vaccine. Normal cells do not posses TSAs or relevant concentrations of TAAs and hence it is surprising that normal cells are effective as anti-cancer vaccines when administered in combination with primary and/or metastatic tumor cells. More surprisingly, a three way combination of cells obtained from metastasized cells, non metastasized tumor and cells from a normal cell line provided good therapy. For prostate cancer, for example, a vaccine may be based on one or a combination of different immortalized normal cell lines derived from the prostate according to parameters described herein. The cell lines may be lethally irradiated with, for example, gamma irradiation at 50-300 Gy to ensure that they are replication incompetent prior to use.

  Recently Added Patents
Structural plasticity in spiking neural networks with symmetric dual of an electronic neuron
Field device for determining or monitoring a physical or chemical process variable
Communication system
Data recording apparatus with recording control based on defect block and control method thereof
Asynchronous distributed de-duplication for replicated content addressable storage clusters
Method and system for filtering home-network content
Chemically resistant membranes, coatings and films and methods for their preparation
  Randomly Featured Patents
Load-dependent variable frequency voltage regulator
Toaster-cum-microwave oven having a humidity measuring device
Seat mount structure for saddle ride vehicle
UV curable catalyst compositions
Fluid cracking process using sepiolite-containing catalyst composition
Analog to digital conversion with signal expansion
Identifying influencers among a group of wireless-subscription subscribers
Compound threads, fabrics provided therefrom and process to obtain them
3-Heterothio[(oxyalkyl)thioacetyl]cephalosporin derivatives
Systems for generating high voltage pulses with a transmission line