Resources Contact Us Home
Recombinant toxin fragments

Image Number 4 for United States Patent #8017134.

A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the polypeptide, or both. The polypeptide thus combines useful properties of a clostridial toxin, such as a botulinum or tetanus toxin, without the toxicity associated with the natural molecule. The polypeptide can also contain a third domain that targets it to a specific cell, rendering the polypeptide useful in inhibition of exocytosis in target cells. Fusion proteins comprising the polypeptide, nucleic acids encoding the polypeptide and methods of making the polypeptide are also provided. Controlled activation of the polypeptide is possible and the polypeptide can be incorporated into vaccines and toxin assays.

  Recently Added Patents
User control of replacement television advertisements inserted by a smart television
Sweetener compositions having enhanced sweetness and improved temporal and/or flavor profiles
Quinoid thiophene organic photoelectric material, preparation method thereof and application thereof
Transmission device
Channel marking for chip mark overflow and calibration errors
Wavelength and power scalable waveguiding-based infrared laser system
Distortion estimation for quantized data
  Randomly Featured Patents
Composite film and packaging material of polypropylene base and surface polymer composition
Biomass pretreatment
Silicone gel filled prosthesis
Adjustable motorcycle securing device
Packaging pouch for absorbent article
Video signal coding of plural related frame sequences for selective replay
Fuel supply system for multi-fuel internal combustion engines
Chip resistor substrate
Large capacity ATM switch
Process for producing bifidogenic infant and dietetic foods reduced in antigenicity