Resources Contact Us Home
Recombinant toxin fragments

Image Number 4 for United States Patent #8017134.

A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the polypeptide, or both. The polypeptide thus combines useful properties of a clostridial toxin, such as a botulinum or tetanus toxin, without the toxicity associated with the natural molecule. The polypeptide can also contain a third domain that targets it to a specific cell, rendering the polypeptide useful in inhibition of exocytosis in target cells. Fusion proteins comprising the polypeptide, nucleic acids encoding the polypeptide and methods of making the polypeptide are also provided. Controlled activation of the polypeptide is possible and the polypeptide can be incorporated into vaccines and toxin assays.

  Recently Added Patents
Ceiling lamp
Moisture sensor
Video signal processing apparatus and control method thereof
Concrete saw
Method of hydration; infusion packet system(s), support member(s), delivery system(s), and method(s); with business model(s) and Method(s)
Systems and methods for subsea drilling
Integrated circuit communication system with differential signal and method of manufacture thereof
  Randomly Featured Patents
Assembling hand grips onto handles
Aluminum-oxy compound, catalyst component for polymerizing olefin, and method for producing polyolefin
Pesticidal benzoylurea compounds
Use of simple amino acids to form porous particles during spray drying
IR thermometry probe cover
Extension hair having guide loop
Battery charger with temperature compensation
Flotation cell and injector
Force transmission linkage for automotive vehicles
High throughput wireless data communication using transferred protocol data for communication across land-line network