Resources Contact Us Home
Recombinant toxin fragments

Image Number 4 for United States Patent #8017134.

A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the polypeptide, or both. The polypeptide thus combines useful properties of a clostridial toxin, such as a botulinum or tetanus toxin, without the toxicity associated with the natural molecule. The polypeptide can also contain a third domain that targets it to a specific cell, rendering the polypeptide useful in inhibition of exocytosis in target cells. Fusion proteins comprising the polypeptide, nucleic acids encoding the polypeptide and methods of making the polypeptide are also provided. Controlled activation of the polypeptide is possible and the polypeptide can be incorporated into vaccines and toxin assays.

  Recently Added Patents
Method and apparatus for reducing power consumption used in communication system having time slots
PMI feedback with codebook interpolation
Optical analysis device, optical analysis method and computer program for optical analysis
Particles with high surface charge for crystalline colloidal arrays
Method and apparatus for secure transfer and playback of multimedia content
Structural plasticity in spiking neural networks with symmetric dual of an electronic neuron
Transmission apparatus, receiving apparatus, method, and storage medium
  Randomly Featured Patents
Transition collar and spacing device for use in road construction
Beamforming multiple-input multiple-output wireless techniques using spatial decomposition for frequency division duplex systems
Decanting apparatus
Formation and treatment of epitaxial layer containing silicon and carbon
Transparent conductive films and methods of producing same
Cell having a separator comprising a macroporous matrix and a porous polymer
Food for skin moisture retention
System for feeding and positioning articles being processed
Self-repairing concrete having polyurethane polymer micro-capsules and method for fabricating the same
Polyoxyalkylene surfactants