Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Recombinant toxin fragments










Image Number 4 for United States Patent #8017134.

A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the polypeptide, or both. The polypeptide thus combines useful properties of a clostridial toxin, such as a botulinum or tetanus toxin, without the toxicity associated with the natural molecule. The polypeptide can also contain a third domain that targets it to a specific cell, rendering the polypeptide useful in inhibition of exocytosis in target cells. Fusion proteins comprising the polypeptide, nucleic acids encoding the polypeptide and methods of making the polypeptide are also provided. Controlled activation of the polypeptide is possible and the polypeptide can be incorporated into vaccines and toxin assays.








 
 
  Recently Added Patents
Control of an electric machine
Binder for secondary battery providing excellent adhesion strength and cycle property
Buried object detection in GPR images
Radiation-emitting semiconductor chip and method for producing a radiation-emitting semiconductor chip
Sampling switch circuit that uses correlated level shifting
Subscribing to content
Architecture, system and method for testing resistive type memory
  Randomly Featured Patents
Method of providing read bias during servo block write
Elevator installation with flat-belt-type suspension means arranged in parallel
Hockey padding
Electrostatic spray assembly
Voice-operated remote control
Combined radio pager/timepiece apparatus with receiver desensitization protection
Cable and the like protection and guide device
Pivot mount
Control system for cooking appliance employing convection and radiant cooking
Vibratory welded window and door joints, method and apparatus for manufacturing the same