Resources Contact Us Home
Recombinant toxin fragments

Image Number 4 for United States Patent #8017134.

A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the polypeptide, or both. The polypeptide thus combines useful properties of a clostridial toxin, such as a botulinum or tetanus toxin, without the toxicity associated with the natural molecule. The polypeptide can also contain a third domain that targets it to a specific cell, rendering the polypeptide useful in inhibition of exocytosis in target cells. Fusion proteins comprising the polypeptide, nucleic acids encoding the polypeptide and methods of making the polypeptide are also provided. Controlled activation of the polypeptide is possible and the polypeptide can be incorporated into vaccines and toxin assays.

  Recently Added Patents
Phase locking loop
Wireless communication power control
Display device and method of manufacturing the same
Bluetooth headset
Device, system, and method for logging near field communications tag interactions
Encoding digital content based on models for predicting similarity between exemplars
Closed cell culture system
  Randomly Featured Patents
Method of and apparatus for sealing surgical suture packages
Liquid ink writing instrument with a shape memory valve
Gazania plant
Launcher training system
Transitional image display for mobile phone
Remote data gateway
Variable start-up circuit for switching regulators
Wiper for multiple and independent surfaces
Water supply line tapping tool
Single transistor type magnetic random access memory device and method of operating and manufacturing the same