Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Recombinant toxin fragments










Image Number 4 for United States Patent #8017134.

A single polypeptide is provided which comprises first and second domains. The first domain enables the polypeptide to cleave one or more vesicle or plasma-membrane associated proteins essential to exocytosis, and the second domain enables the polypeptide to be translocated into a target cell or increases the solubility of the polypeptide, or both. The polypeptide thus combines useful properties of a clostridial toxin, such as a botulinum or tetanus toxin, without the toxicity associated with the natural molecule. The polypeptide can also contain a third domain that targets it to a specific cell, rendering the polypeptide useful in inhibition of exocytosis in target cells. Fusion proteins comprising the polypeptide, nucleic acids encoding the polypeptide and methods of making the polypeptide are also provided. Controlled activation of the polypeptide is possible and the polypeptide can be incorporated into vaccines and toxin assays.








 
 
  Recently Added Patents
Concentration measuring apparatus for hydrogen sulfide in gas flow, and method for determining sulfide ion
Inhibitor of casein kinase 1delta and casein kinase 1E
Document layout method
Virtual appliance update method
(4949
Signal conversion control circuit for touch screen and method thereof
Programming method of non-volatile memory device
  Randomly Featured Patents
Apparatus and method for auto-retroperfusion of a coronary vein
Light-irradiating beauty apparatus
Process for producing electrophoretic display
Magnetic lens and electron beam deflection system
Castor brake assembly
Independent, redundant overvoltage protection for a generator
Ink jet cartridge, ink jet apparatus, and manufacture method of ink jet cartridge
Apparatus and method for charging and discharging serially-connected batteries
Method to control fracture orientation in underground formation
Apparatus, method, and program for arithmetic processing