Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS










Image Number 19 for United States Patent #8012949.

The disclosure provides, inter alia, novel bisphosphonate compounds and methods of making and using such compounds. In certain embodiments, compounds of the invention include bisphosphonates that are capable of selectively inhibiting one or more of farnesyl diphosphate synthase (FPPS), geranylgeranyl diphosphate synthase (GGPPS), and decaprenyl pyrophosphate synthase (DPPS). In preferred embodiments, compounds of the invention are capable of selectively inhibiting two or more of FPPS, GGPPS, and DPPS. In embodiments, compounds and methods of the invention demonstrate superior activity levels, such as in the anti-cancer context, immunostimulation context, and other contexts, which in several cases exceed the activity levels of previous generation bisphosphonate drugs by orders of magnitude. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor or cancer cell growth inhibition, activation of gammadelta T cells, inhibition of certain enzymes related to the mevalonate metabolic pathway, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases.








 
 
  Recently Added Patents
Optical disc
Computer-readable storage medium, image recognition apparatus, image recognition system, and image recognition method
Mass spectrometry analysis of microorganisms in samples
Cavity filter having feedback arrangement
Method and communication device for transmitting packet-oriented information
Lithography mask functional optimization and spatial frequency analysis
Multi-channel sessions
  Randomly Featured Patents
Intercom system for a key telephone system
Folding and delivery device for double-layered carton sealing machine
Fluid dispenser apparatus
Memory module assembly
Color keeping slip-resisting solution
Apparatus, method and computer program product for guaranteed content delivery incorporating putting a client on-hold based on response time
Torque-applying tool and control therefor
Vehicle door latch device
Method and apparatus for sorting products by features
Electric shaver