Resources Contact Us Home
Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS

Image Number 19 for United States Patent #8012949.

The disclosure provides, inter alia, novel bisphosphonate compounds and methods of making and using such compounds. In certain embodiments, compounds of the invention include bisphosphonates that are capable of selectively inhibiting one or more of farnesyl diphosphate synthase (FPPS), geranylgeranyl diphosphate synthase (GGPPS), and decaprenyl pyrophosphate synthase (DPPS). In preferred embodiments, compounds of the invention are capable of selectively inhibiting two or more of FPPS, GGPPS, and DPPS. In embodiments, compounds and methods of the invention demonstrate superior activity levels, such as in the anti-cancer context, immunostimulation context, and other contexts, which in several cases exceed the activity levels of previous generation bisphosphonate drugs by orders of magnitude. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor or cancer cell growth inhibition, activation of gammadelta T cells, inhibition of certain enzymes related to the mevalonate metabolic pathway, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases.

  Recently Added Patents
Switching element for a valve train of an internal combustion engine
Computer system for routing package deliveries
Computer product, information retrieval method, and information retrieval apparatus
Distributed image acquisition, storage, and backup system
Sensor apparatus and information processing apparatus
Battery terminal with current sensor
Universal data-driven computer proxy
  Randomly Featured Patents
Spark plug location for split-cycle engine
Method for the production of D-chiroinositol
Phase locked loop with automatic sweep
Method and apparatus for ink-jet printing
Excess flow valves
Label system for package and baggage handling
Candle lamp
Audio and video effect stapler
Method and system for separating text and drawings in digital ink