Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS










Image Number 19 for United States Patent #8012949.

The disclosure provides, inter alia, novel bisphosphonate compounds and methods of making and using such compounds. In certain embodiments, compounds of the invention include bisphosphonates that are capable of selectively inhibiting one or more of farnesyl diphosphate synthase (FPPS), geranylgeranyl diphosphate synthase (GGPPS), and decaprenyl pyrophosphate synthase (DPPS). In preferred embodiments, compounds of the invention are capable of selectively inhibiting two or more of FPPS, GGPPS, and DPPS. In embodiments, compounds and methods of the invention demonstrate superior activity levels, such as in the anti-cancer context, immunostimulation context, and other contexts, which in several cases exceed the activity levels of previous generation bisphosphonate drugs by orders of magnitude. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor or cancer cell growth inhibition, activation of gammadelta T cells, inhibition of certain enzymes related to the mevalonate metabolic pathway, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases.








 
 
  Recently Added Patents
Integrated multi-sat LNB and frequency translation module
Telephone relaying apparatus, telephone relaying method, and program
Porous polymeric resins
Systems and methods for excluding undesirable network transactions
Mass spectrometry method
Preferential selection of candidates for delta compression
Computer server capable of supporting CPU virtualization
  Randomly Featured Patents
Propynylaminothiazole derivatives
Beverage maker
Soybean cultivar SG5322NRR
Dental hygiene composition for reducing periodontal disease
System for aperturing and coaperturing webs and web assemblies
Programmable fractional-N clock generators
Robust encoder for folding analog to digital converter
Connecting rod assembly
Optical connector
Recovery of metal values from manganese deep sea nodules using ammoniacal cuprous leach solutions