Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS










Image Number 19 for United States Patent #8012949.

The disclosure provides, inter alia, novel bisphosphonate compounds and methods of making and using such compounds. In certain embodiments, compounds of the invention include bisphosphonates that are capable of selectively inhibiting one or more of farnesyl diphosphate synthase (FPPS), geranylgeranyl diphosphate synthase (GGPPS), and decaprenyl pyrophosphate synthase (DPPS). In preferred embodiments, compounds of the invention are capable of selectively inhibiting two or more of FPPS, GGPPS, and DPPS. In embodiments, compounds and methods of the invention demonstrate superior activity levels, such as in the anti-cancer context, immunostimulation context, and other contexts, which in several cases exceed the activity levels of previous generation bisphosphonate drugs by orders of magnitude. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor or cancer cell growth inhibition, activation of gammadelta T cells, inhibition of certain enzymes related to the mevalonate metabolic pathway, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases.








 
 
  Recently Added Patents
Method for pulse-based ultra-broadband communication between at least one transmitting node and at least one receiving node
Transparent computer stand
Compounds, intermediates, and methods of preparing the same
Earthquake damage prediction and prevention system and method thereof
System and method for detection of analytes in exhaled breath
Mobile phone
Remote control-based instant messaging
  Randomly Featured Patents
Fluid system having controllable reversible viscosity
Liquid crystal polymer film and a method for manufacturing the same
6-phenyl-2-[((piperidin-4-ylmethyl)-piperazin-1YL) or piperazin 1-ylmethyl)-piperidin-1-yl)]-imidazo[2,1-B][1,3,4]thiadiazole derivatives and their use
Adornment defined using frayed material
Air conditioning control system with master and tracking controllers
Electrical printed circuit board and process
Polarization independent birefringent tunable filters
Reflection type liquid-crystal display apparatus
System for distributing and recovering digitized composite SECAM samples in a two channel digital apparatus
Process for purifying molybdenum