Resources Contact Us Home
Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS

Image Number 19 for United States Patent #8012949.

The disclosure provides, inter alia, novel bisphosphonate compounds and methods of making and using such compounds. In certain embodiments, compounds of the invention include bisphosphonates that are capable of selectively inhibiting one or more of farnesyl diphosphate synthase (FPPS), geranylgeranyl diphosphate synthase (GGPPS), and decaprenyl pyrophosphate synthase (DPPS). In preferred embodiments, compounds of the invention are capable of selectively inhibiting two or more of FPPS, GGPPS, and DPPS. In embodiments, compounds and methods of the invention demonstrate superior activity levels, such as in the anti-cancer context, immunostimulation context, and other contexts, which in several cases exceed the activity levels of previous generation bisphosphonate drugs by orders of magnitude. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor or cancer cell growth inhibition, activation of gammadelta T cells, inhibition of certain enzymes related to the mevalonate metabolic pathway, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases.

  Recently Added Patents
Method of forming a power supply controller and structure therefor
Memory device program window adjustment
Electronic device and printed circuit board
Quantitative oxygen imaging systems and methods using echo-based single point imaging
Obviation of recovery of data store consistency for application I/O errors
Magnetoresistive shield with coupled lateral magnet bias
Scalable pixel coverage function-map
  Randomly Featured Patents
Fluid dispenser valve with rolling diaphragm
System for utilizing a conventional n-bit successive approximation register to generate data words with more than n places
Method of manufacturing sinter-active U.sub.3O.sub.8 powder and method of producing nuclear fuel pellets utilizing the same
Method and device for welding protected metal parts
Upright for lift truck
Monitor for medical equipment
Internal prosthesis with radiopaque annular portions
Holographic transflector
Refrigerator with carbonated water distributor
Security system