Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Recombinant toxin fragments










Image Number 19 for United States Patent #8012479.

Antigenic compositions are provided comprising a single chain polypeptide comprising first and second domains, wherein said first domain is a clostridial neurotoxin light chain or a fragment or a variant thereof and is capable of cleaving one or more vesicle or plasma membrane associated proteins essential to exocytosis; and said second domain is a clostridial neurotoxin heavy chain H.sub.N portion or a fragment or a variant thereof, wherein said second domain is capable of (i) translocating the polypeptide into a cell or (ii) increasing the solubility of the polypeptide compared to the solubility of the first domain on its own or (iii) both translocating the polypeptide into a cell and increasing the solubility of the polypeptide compared to the solubility of the first domain on its own; and wherein the second domain lacks a functional C-terminal part of a clostridial neurotoxin heavy chain designated H.sub.C thereby rendering the polypeptide incapable of binding to cell surface receptors that are the natural cell surface receptors to which native clostridial neurotoxin binds. Antibodies that bind to the polypeptides, and compositions comprising these antibodies, are also provided, as are DNA vaccines comprising polynucleotides that encode these polypeptides. The antigenic and antibody compositions, and the DNA vaccine compositions, can be used in methods of immunising against, or treating, clostridial neurotoxin poisoning in a subject by administering to that subject a therapeutically effective amount of the composition.








 
 
  Recently Added Patents
Exposure apparatus, exposure method, and device manufacturing method
Network attachment for IMS systems for legacy CS UE with home node B access
Substantially aligned boron nitride nano-element arrays and methods for their use and preparation
Taxi cab key chain
Stroboscopic light source for a transmitter of a large scale metrology system
Selection of hash lookup keys for efficient retrieval
Automatic fixup of network configuration on system image move
  Randomly Featured Patents
Compact deployable acoustic sensor
Petunia plant named `Duepotpihop`
Driver circuit for solenoid operated fuel injectors
Rapid etching method for silicon by SF.sub.6 gas
Speaker apparatus to be mounted on a vehicle
Machine oil deterioration detection
Electromagnetic clutch
Method for preventing erroneous loading of component-to-be-loaded on main body side apparatus, component-to-be-loaded and battery pack
Retransmission apparatus using IP multicasting method for DMB service
Device to correct the longitudinal torsion in a tubular fabric