Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Recombinant toxin fragments










Image Number 19 for United States Patent #8012479.

Antigenic compositions are provided comprising a single chain polypeptide comprising first and second domains, wherein said first domain is a clostridial neurotoxin light chain or a fragment or a variant thereof and is capable of cleaving one or more vesicle or plasma membrane associated proteins essential to exocytosis; and said second domain is a clostridial neurotoxin heavy chain H.sub.N portion or a fragment or a variant thereof, wherein said second domain is capable of (i) translocating the polypeptide into a cell or (ii) increasing the solubility of the polypeptide compared to the solubility of the first domain on its own or (iii) both translocating the polypeptide into a cell and increasing the solubility of the polypeptide compared to the solubility of the first domain on its own; and wherein the second domain lacks a functional C-terminal part of a clostridial neurotoxin heavy chain designated H.sub.C thereby rendering the polypeptide incapable of binding to cell surface receptors that are the natural cell surface receptors to which native clostridial neurotoxin binds. Antibodies that bind to the polypeptides, and compositions comprising these antibodies, are also provided, as are DNA vaccines comprising polynucleotides that encode these polypeptides. The antigenic and antibody compositions, and the DNA vaccine compositions, can be used in methods of immunising against, or treating, clostridial neurotoxin poisoning in a subject by administering to that subject a therapeutically effective amount of the composition.








 
 
  Recently Added Patents
Patterned birefringent product
Wind farm, wind power plant in a wind farm and operating control for this purpose
Ottoman
Stock analysis method, computer program product, and computer-readable recording medium
Changing a system clock rate synchronously
ESD protection circuit and ESD protection device thereof
Organic light emitting diode display device and method of fabricating the same
  Randomly Featured Patents
Dielectric ceramic composition for microwave frequencies
Process for the production of sclareolide
System for calibration of dual polarization radar with built-in test couplers
Portable computer with operation pen
High profile thread forming screw
Apparatus and method for supporting a structure with a pier and helix
Computer input device and keyboard
Field emission display, method for measuring vacuum degree thereof and method for automatically activating getter thereof
Gasket and gasket tape and method of making and using the same
Heterocyclylindazole and -azaindazole compounds as 5-hydroxytryptamine-6 ligands