Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Recombinant toxin fragments










Image Number 19 for United States Patent #8012479.

Antigenic compositions are provided comprising a single chain polypeptide comprising first and second domains, wherein said first domain is a clostridial neurotoxin light chain or a fragment or a variant thereof and is capable of cleaving one or more vesicle or plasma membrane associated proteins essential to exocytosis; and said second domain is a clostridial neurotoxin heavy chain H.sub.N portion or a fragment or a variant thereof, wherein said second domain is capable of (i) translocating the polypeptide into a cell or (ii) increasing the solubility of the polypeptide compared to the solubility of the first domain on its own or (iii) both translocating the polypeptide into a cell and increasing the solubility of the polypeptide compared to the solubility of the first domain on its own; and wherein the second domain lacks a functional C-terminal part of a clostridial neurotoxin heavy chain designated H.sub.C thereby rendering the polypeptide incapable of binding to cell surface receptors that are the natural cell surface receptors to which native clostridial neurotoxin binds. Antibodies that bind to the polypeptides, and compositions comprising these antibodies, are also provided, as are DNA vaccines comprising polynucleotides that encode these polypeptides. The antigenic and antibody compositions, and the DNA vaccine compositions, can be used in methods of immunising against, or treating, clostridial neurotoxin poisoning in a subject by administering to that subject a therapeutically effective amount of the composition.








 
 
  Recently Added Patents
Navigation system and navigation apparatus
Platform for generating electricity from flowing fluid using generally prolate turbine
Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
Email certificates
Load control device
System and method for multi-threaded MIMO OFDM channel equalizer
Charged particle source with integrated electrostatic energy filter
  Randomly Featured Patents
High frequency circuit, semiconductor device, and high frequency power amplification device
Active magnetic guide apparatus for an elevator car
Vane with sides that are both convex and concave for use in coverings for architectural openings
Method, apparatus, and computer program of searching for clustering faults in semiconductor device manufacturing
Surface mounting connector
Sampler
Optical analog-to-digital converter
Method of manufacturing an acoustic transducer
Variable geometry seasoning tumbler
Acrylic syrup and method of producing same