Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Recombinant toxin fragments










Image Number 19 for United States Patent #8012479.

Antigenic compositions are provided comprising a single chain polypeptide comprising first and second domains, wherein said first domain is a clostridial neurotoxin light chain or a fragment or a variant thereof and is capable of cleaving one or more vesicle or plasma membrane associated proteins essential to exocytosis; and said second domain is a clostridial neurotoxin heavy chain H.sub.N portion or a fragment or a variant thereof, wherein said second domain is capable of (i) translocating the polypeptide into a cell or (ii) increasing the solubility of the polypeptide compared to the solubility of the first domain on its own or (iii) both translocating the polypeptide into a cell and increasing the solubility of the polypeptide compared to the solubility of the first domain on its own; and wherein the second domain lacks a functional C-terminal part of a clostridial neurotoxin heavy chain designated H.sub.C thereby rendering the polypeptide incapable of binding to cell surface receptors that are the natural cell surface receptors to which native clostridial neurotoxin binds. Antibodies that bind to the polypeptides, and compositions comprising these antibodies, are also provided, as are DNA vaccines comprising polynucleotides that encode these polypeptides. The antigenic and antibody compositions, and the DNA vaccine compositions, can be used in methods of immunising against, or treating, clostridial neurotoxin poisoning in a subject by administering to that subject a therapeutically effective amount of the composition.








 
 
  Recently Added Patents
Treatment of influenza
Asymmetric switching rectifier
Range extension techniques for a wireless local area network
Automotive lighting system
Battery comprising circuitry for charge and discharge control, and method of operating a battery
Digital image processing device and processing method thereof
Receiver with feedback continuous-time delta-sigma modulator with current-mode input
  Randomly Featured Patents
Method of coating polymeric tubes used in medical devices
Automobile headlamp with continuous edges between stepped surfaces
Manufacturing method of color picture tube
Inkjet print head and ink storage apparatus
Method and apparatus for polishing a substrate
Self watering tray for regular plant pot
Process for preparing 2-cyanoindan-1-ones
DSX illuminator
PWM/linear driver for disk drive voice coil actuator
Curtain air bag apparatus