Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Recombinant toxin fragments










Image Number 19 for United States Patent #8012479.

Antigenic compositions are provided comprising a single chain polypeptide comprising first and second domains, wherein said first domain is a clostridial neurotoxin light chain or a fragment or a variant thereof and is capable of cleaving one or more vesicle or plasma membrane associated proteins essential to exocytosis; and said second domain is a clostridial neurotoxin heavy chain H.sub.N portion or a fragment or a variant thereof, wherein said second domain is capable of (i) translocating the polypeptide into a cell or (ii) increasing the solubility of the polypeptide compared to the solubility of the first domain on its own or (iii) both translocating the polypeptide into a cell and increasing the solubility of the polypeptide compared to the solubility of the first domain on its own; and wherein the second domain lacks a functional C-terminal part of a clostridial neurotoxin heavy chain designated H.sub.C thereby rendering the polypeptide incapable of binding to cell surface receptors that are the natural cell surface receptors to which native clostridial neurotoxin binds. Antibodies that bind to the polypeptides, and compositions comprising these antibodies, are also provided, as are DNA vaccines comprising polynucleotides that encode these polypeptides. The antigenic and antibody compositions, and the DNA vaccine compositions, can be used in methods of immunising against, or treating, clostridial neurotoxin poisoning in a subject by administering to that subject a therapeutically effective amount of the composition.








 
 
  Recently Added Patents
Metal melting apparatus and method for melting metal
Method and system for constructing a customized web analytics application
Nutritional supplement method
Method and system for providing magnetic junctions having improved characteristics
Polishing composition
Serving base station selection based on backhaul capability
Position and orientation measurement apparatus, position and orientation measurement method, and storage medium
  Randomly Featured Patents
Microcapsule sheet for pressure-sensitive recording paper
Hauling and shaving plant
Releasable loop retainer
Apparatus for arresting posterior nosebleeds
Low noise, high frequency synchronous rectifier
Impact resistant bumper for vehicles
Word line driver cell layout for SRAM and other semiconductor devices
Error concealment apparatus for a compressed video signal processing system
Organopolysiloxane composition and rubber substrate having a coating thereof
Gift item candle with falling sections