Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Recombinant toxin fragments










Image Number 19 for United States Patent #8012479.

Antigenic compositions are provided comprising a single chain polypeptide comprising first and second domains, wherein said first domain is a clostridial neurotoxin light chain or a fragment or a variant thereof and is capable of cleaving one or more vesicle or plasma membrane associated proteins essential to exocytosis; and said second domain is a clostridial neurotoxin heavy chain H.sub.N portion or a fragment or a variant thereof, wherein said second domain is capable of (i) translocating the polypeptide into a cell or (ii) increasing the solubility of the polypeptide compared to the solubility of the first domain on its own or (iii) both translocating the polypeptide into a cell and increasing the solubility of the polypeptide compared to the solubility of the first domain on its own; and wherein the second domain lacks a functional C-terminal part of a clostridial neurotoxin heavy chain designated H.sub.C thereby rendering the polypeptide incapable of binding to cell surface receptors that are the natural cell surface receptors to which native clostridial neurotoxin binds. Antibodies that bind to the polypeptides, and compositions comprising these antibodies, are also provided, as are DNA vaccines comprising polynucleotides that encode these polypeptides. The antigenic and antibody compositions, and the DNA vaccine compositions, can be used in methods of immunising against, or treating, clostridial neurotoxin poisoning in a subject by administering to that subject a therapeutically effective amount of the composition.








 
 
  Recently Added Patents
Hook
Wafer processing method and system using multi-zone chuck
Managing job execution
Pharmaceutical composition comprising gabapentin or an analogue thereof and an .alpha.-aminoamide and its analgesic use
System and method for associating financial transaction data with a user's project data using a portable electronic device
Purine compounds used as CB2 agonists
Interactivity model for shared feedback on mobile devices
  Randomly Featured Patents
Test apparatus for magnetic resonance imaging systems
Light switch
Method of manufacturing generic meters in a key management system
Candle wax composition
System and method for converting unicast client requests into multicast client requests
Portable object having multi-level demodulation and being inductively coupled to a fixed station
Reducing E. coli content of beef
Rear end strut
Method and apparatus for encoding transmitting and receiving image by pulse code modulation
Two-level display device with hatching control means