Resources Contact Us Home
Monoclonal antibody to CD166 and method for production thereof

Image Number 2 for United States Patent #8003762.

CD166 is a cell adhesion molecule belonging to an immunoglobulin superfamily that is expressed in an excessive amount on the tumor surface. If an monoclonal antibody specifically binding to the CD166 is obtained, it becomes possible to suppress growth of tumor cells, detect the cells, and supply a therapeutic drug thereto specifically. However, because the CD166 proteins are very similar to each other among mammals, it was not possible to obtain an antibody to human CD166, by immunizing, for example, mice with the human CD166. The antibody was prepared by immunizing mice with a purified avian CD166 protein. The antibody was found to be adsorbed on human and mouse CD166 proteins in vitro as well as in vivo and to have an action to suppress tumor growth in mice.

  Recently Added Patents
Channel marking for chip mark overflow and calibration errors
Simplifying lexicon creation in hybrid duplicate detection and inductive classifier systems
Integrated multi-sat LNB and frequency translation module
Method and system for expanding axial coverage in iterative reconstruction in computer tomography (CT)
Microwavable bag
Method for detection and characterization of a microorganism in a sample using time-dependent intrinsic fluorescence measurements
Peer-to-peer method of deploying and managing executable code and associated plug-ins
  Randomly Featured Patents
Voltage controlled oscillator having equally controlled current source and current sink
Drive system, in particular for a motor vehicle
Watch housing for a wrist watch
Methods and apparatus for management of configuration item lifecycle state transitions
Capacitive sensor
Vertical arc trainer
Crosslinked polymer aerogels, polymer aerogel composites and methods for preparing the same
PACAP compositions and methods for tumor imaging and therapy
Modeling low frame rate videos with bayesian estimation