Resources Contact Us Home
Monoclonal antibody to CD166 and method for production thereof

Image Number 2 for United States Patent #8003762.

CD166 is a cell adhesion molecule belonging to an immunoglobulin superfamily that is expressed in an excessive amount on the tumor surface. If an monoclonal antibody specifically binding to the CD166 is obtained, it becomes possible to suppress growth of tumor cells, detect the cells, and supply a therapeutic drug thereto specifically. However, because the CD166 proteins are very similar to each other among mammals, it was not possible to obtain an antibody to human CD166, by immunizing, for example, mice with the human CD166. The antibody was prepared by immunizing mice with a purified avian CD166 protein. The antibody was found to be adsorbed on human and mouse CD166 proteins in vitro as well as in vivo and to have an action to suppress tumor growth in mice.

  Recently Added Patents
Apparatus with a local timing circuit that generates a multi-phase timing signal for a digital signal processing circuit
Method for production of a thermoelectric apparatus
Case for electronic device
Spin transition material
Method and an apparatus for processing an audio signal
Can seam inspection
Chip on film (COF) package having test line for testing electrical function of chip and method for manufacturing same
  Randomly Featured Patents
Air bag
Portable electronic apparatus including detachable system and expansion modules
Apparatus for cleaning the side-edge and top-edge of a semiconductor wafer
Modified membranes
Digitally convertible radio
Security gate
Method for feature selection in a support vector machine using feature ranking
Radiopharmaceutical chelates and method of external imaging
Adaptive storage system including hard disk drive with flash interface
Snap-in bushing switch removal tool