Resources Contact Us Home
Monoclonal antibody to CD166 and method for production thereof

Image Number 2 for United States Patent #8003762.

CD166 is a cell adhesion molecule belonging to an immunoglobulin superfamily that is expressed in an excessive amount on the tumor surface. If an monoclonal antibody specifically binding to the CD166 is obtained, it becomes possible to suppress growth of tumor cells, detect the cells, and supply a therapeutic drug thereto specifically. However, because the CD166 proteins are very similar to each other among mammals, it was not possible to obtain an antibody to human CD166, by immunizing, for example, mice with the human CD166. The antibody was prepared by immunizing mice with a purified avian CD166 protein. The antibody was found to be adsorbed on human and mouse CD166 proteins in vitro as well as in vivo and to have an action to suppress tumor growth in mice.

  Recently Added Patents
Server-side connection resource pooling
Scattering spectroscopy employing hotspot-aligned nanopores
Method of inspecting wafer
Switching element for a valve train of an internal combustion engine
Differentiated PSIP table update interval technology
Switchgear operating apparatus and three-phase switchgear
Controlling a video window position relative to a video camera position
  Randomly Featured Patents
Flexible multilayer structure for tubes
Foam dart gun
Shock responsive momentary relay
Top layers of metal for high performance IC's
Display stand
Perimeter wall panels for an air supported structure
Contact spring assembly, especially for an antenna amplifier
Dehydrochlorination of hydrochlorofluorocarbons using pre-treated activated carbon catalysts
Method of producing corners in channel material using ultrasonic energy