Resources Contact Us Home
Monoclonal antibody to CD166 and method for production thereof

Image Number 2 for United States Patent #8003762.

CD166 is a cell adhesion molecule belonging to an immunoglobulin superfamily that is expressed in an excessive amount on the tumor surface. If an monoclonal antibody specifically binding to the CD166 is obtained, it becomes possible to suppress growth of tumor cells, detect the cells, and supply a therapeutic drug thereto specifically. However, because the CD166 proteins are very similar to each other among mammals, it was not possible to obtain an antibody to human CD166, by immunizing, for example, mice with the human CD166. The antibody was prepared by immunizing mice with a purified avian CD166 protein. The antibody was found to be adsorbed on human and mouse CD166 proteins in vitro as well as in vivo and to have an action to suppress tumor growth in mice.

  Recently Added Patents
Voltage regulator soft-start circuit providing reference voltage ramp-up
Internet applications and services for rendering digital content
Route guidance apparatus, route guidance method, and program
Belt adjuster
Method for the operation of synchronous motors, and associated device
Control message processing method in wireless mesh network and control message processing apparatus using the method
  Randomly Featured Patents
System and method for transmitting data from a computer to a portable information device using RF emissions from a computer monitor
Flywheel assembly and a torque converter
Allocating bandwidth in a resilient packet ring network by P controller
Memory driver architecture and associated methods
Method of treating sexual disturbances
Electrophotographic image forming apparatus including means for correcting density drift
Revolving door braking and locking device
Coin/token separator
Auxiliary nose piece for eyeglasses
Bandgap control in amorphous semiconductors