Resources Contact Us Home
Clostridium perfringens alpha toxin proteins

Image Number 6 for United States Patent #7982006.

This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic Clostridium perfringens (Cp) .alpha.-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing the Pseudomonas fluorescens system, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cp is also disclosed.

  Recently Added Patents
Method for processing power headroom and terminal thereof
Techniques for distributed storage aggregation
Fabrication of high gradient insulators by stack compression
Escalating data backup protection in response to a failure in a cluster of nodes
Image forming apparatus and warming up method thereof
Electromagnetic probe for measuring properties of a subsurface formation
Illumination unit for a direct-view display
  Randomly Featured Patents
Method and apparatus for endoscopic blood flow detection by the use of ultrasonic energy
Latch assembly for movable closure element
Portable wellhead and welder protector system
Moisture curable silicone urea hot melt reinforced by organic polymers
Gastrointestinal probe
Whole fruit size grader
Connector module for transducer
Method and apparatus for dehydrating sludge
Occlusion perfusion catheter
Capsule endoscopic system and operation control method of capsule endoscope