Resources Contact Us Home
Clostridium perfringens alpha toxin proteins

Image Number 6 for United States Patent #7982006.

This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic Clostridium perfringens (Cp) .alpha.-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing the Pseudomonas fluorescens system, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cp is also disclosed.

  Recently Added Patents
Watch dial
Magnetic resonance imaging apparatus
Multi-protocol data transfers
Multi-user remote health monitoring system with biometrics support
Packet transmission system and fault recovery method
Method of processing data and display apparatus for performing the method
Critical word forwarding with adaptive prediction
  Randomly Featured Patents
Restoration of deteriorated plaster surfaces
Golf grip with hand placement guide
Identifying an optimized test bit pattern for analyzing electrical communications channel topologies
Preparation of optically active hydrazines and amines
Flavor-active peptides
Sheet delivery for a printing press
Device for constructing modular water spray configurations
Starting mechanism of an engine for a model
Low contact force spring
Information providing server, information providing method, and information providing system