Resources Contact Us Home
Clostridium perfringens alpha toxin proteins

Image Number 10 for United States Patent #7982006.

This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic Clostridium perfringens (Cp) .alpha.-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing the Pseudomonas fluorescens system, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cp is also disclosed.

  Recently Added Patents
Method of analyzing cell structures and their components
Stabilised prostaglandin composition
Resuming piecewise calibration of a real-time-clock unit after a measured offset that begins at the next calibration period
Pattern forming method using printing device and method of manufacturing liquid crystal display device using the same
High productivity single pass scanning system
Monofocal photographing lens assembly
Method of patterning color conversion layer and method of manufacturing organic EL display using the patterning method
  Randomly Featured Patents
Cannulated surgical instrument
Use of notched broadband waveforms in a linear ion trap
Circuit for receiving a command word for accessing a secure subkey
Pin grid array removal tool
Grab or grab bucket and method of operating same
Music box device
Cushioning means holding member, and slide switch including the same
Hydrogels and uses thereof
Scoreboard in the form of a city seal