Resources Contact Us Home
Clostridium perfringens alpha toxin proteins

Image Number 10 for United States Patent #7982006.

This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic Clostridium perfringens (Cp) .alpha.-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing the Pseudomonas fluorescens system, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cp is also disclosed.

  Recently Added Patents
Circuit timing analysis incorporating the effects of temperature inversion
Computing correlated aggregates over a data stream
Artificial neural network proteomic tumor classification
Anterior ocular segment related cell sheets, three-dimensional structures, and processes for producing the same
Rotatable polarizer/filter device and feed network using the same
Method and apparatus for combining elongated strips
Congestion management in a shared network
  Randomly Featured Patents
Hollow shell with internal baffle
Spray nozzle apparatus and method
Laser driver pre-emphasis and de-emphasis method and/or architecture with tuning and duty cycle control
Confection container
Method and system for estimating cylinder air charge for an internal combustion engine
Hydraulically driven type working machine
Storage device for storing data while compressing same value input data
Electrical connector system with header connector capable of direct and indirect mounting
High-speed search method for use in a disc player system
Shield timbering frame for timbering mines