Resources Contact Us Home
Clostridium perfringens alpha toxin proteins

Image Number 10 for United States Patent #7982006.

This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic Clostridium perfringens (Cp) .alpha.-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing the Pseudomonas fluorescens system, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cp is also disclosed.

  Recently Added Patents
Idle stop and go system and method for controlling thereof
Catalysts for hydrodeoxygenation of polyols
Methods and systems to reduce a number of simulations in a timing analysis
Stable liquid VEGF antagonist formulations
Integrated circuit with electromagnetic intrachip communication and methods for use therewith
Method and apparatus for editing a program on an optical disc
Compositions and methods for concentrating and depleting microorganisms
  Randomly Featured Patents
Universal optical imaging and processing system
Fiber optics high speed modem
Engine switch device
Methods for accurate identification of an edge of a care area for an array area formed on a wafer and methods for binning defects detected in an array area formed on a wafer
Door and frame molded of fibrous mineral material
Method of halftone screen linearization via continuous gradient patches
Front vehicle body construction
Storage circuit control device and graphic computation device
Combined semiconductor device and printed circuit board assembly
Apparatus for molding roofing panels having a stepped portion