Resources Contact Us Home
Clostridium perfringens alpha toxin proteins

Image Number 10 for United States Patent #7982006.

This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic Clostridium perfringens (Cp) .alpha.-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing the Pseudomonas fluorescens system, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cp is also disclosed.

  Recently Added Patents
Autonomous adaptation of transmit power
Flame-protected impact-modified polycarbonate compositions
Interface circuit and interface system
Vehicle location information-based abnormal driving determination and warning system
Lens system
High-efficiency preambles for communications systems over pseudo-stationary communication channels
Case for electronic device
  Randomly Featured Patents
Method and apparatus for inputting and recognizing characters in a PDA and transferring the recognized characters in parallel to a keyboard buffer of a PC
Method and apparatus for communicating between coordinator-based wireless networks connected through a backbone network
Dispensing container
Long-blade closed-shoe swim fin
Agent for treatment of cerebral ischemic diseases
Injection timing control system for fuel-injection pump for engine
Mixtures of polyarylene sulphides, nitroarylmethylidene ketones, glass fibers and optionally other fillers
Techniques for validating public keys using AAA services
Educational device
Liquid dispenser, supplying and dosing cylinder device, in particular for liquid dispenser and method for manufacturing a liquid dispenser