Resources Contact Us Home
Clostridium perfringens alpha toxin proteins

Image Number 10 for United States Patent #7982006.

This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic Clostridium perfringens (Cp) .alpha.-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing the Pseudomonas fluorescens system, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cp is also disclosed.

  Recently Added Patents
Nanowire structured photodiode with a surrounding epitaxially grown P or N layer
3D IC method and device
Method for adjusting link speed and computer system using the same
Spacers for insulated glass units
Pre and post-paid real time billing convergence system
System for programming domestic appliances and method for programming assembly-line programmable domestic appliances
Systems and methods to provide communication history for communication devices
  Randomly Featured Patents
Spoke nipple for bicycle wheel
Apparatus and method of generating control program
Implementing formulas for custom fields in an on-demand database
Hair cosmetics
High germanium content waveguide materials
Clinical data monitoring and alarming apparatus and methods
Method for treatment and conversion of refuse incineration residues into environmentally acceptable and reusable material, especially for construction purposes
Process for the preparation of furan compounds
Patch-type microwave antenna
Shoe insole