Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
T-cell membrane protein (TIRC7), peptides and antibodies derived therefrom and uses thereof










Image Number 3 for United States Patent #7931901.

Described are generally a T cell immune response cDNA 7 (TIRC7) encoding a novel T-cell transmembrane protein as well as peptides und polypeptides derived therefrom and antibodies recognizing said (poly)peptides. More particularly, peptide and polypeptide as well as antibodies being capable of inhibiting T-cell stimulation through the T-cell membrane protein (TIRC7) are provided. Furthermore, vectors comprising the aforementioned polynucleotides and host cells transformed therewith as well as their use in the production of the above-defined proteins, peptides or polypeptides are described. Additionally, pharmaceutical and diagnostic compositions are provided comprising any one of the afore described polynucleotide, vector, protein, peptide, polypeptide, or antibody. Furthermore, methods and uses for modulating immune responses through the novel TIRC7 membrane protein as well as pharmaceutical compositions comprising agents which act on the TIRC7 membrane protein or its ligand are described. Also, the use of said polynucleotide, vector, protein, peptide, polypeptide, or antibody for the preparation of pharmaceutical compositions for use in organ transplantation, for the treatment of autoimmune, allergic or infectious diseases, or for treatment of tumors is provided. Furthermore, methods for modulating (antigen-specific) T cell unresponsiveness inducing maintaining or reversing T cell unresponsiveness by inhibiting or stimulating an (unresponsive) T cell through the novel TIRC7 membrane protein are encompassed herein.








 
 
  Recently Added Patents
Door-activated entry light fixture
Metal melting apparatus and method for melting metal
RF amplifier with digital filter for polar transmitter
Image forming apparatus and method for making density correction in a low resolution image based on edge determination
Coupling device having piercing member
Semiconductor device
MOS device for eliminating floating body effects and self-heating effects
  Randomly Featured Patents
General protection of an integrated circuit against permant overloads and electrostatic discharges
Methods for the production of 1,3,5-triamino-2,4,6-trinitrobenzene
Micro particles
Organic electroluminescent element
Method for treating waste gas
Reversible thermal recording medium, and method and apparatus for manufacturing the same
Device for counting particles of ionizing radiation and its application to implementing a method of measuring the rate of leakage between the primary and secondary circuits of a steam generato
System and method for integrating and characterizing data from multiple electronic systems
Modified chlorinated carboxylated polyolefins and their use as adhesion promoters
Blade profile for aircraft rotor and rotor comprising same