Resources Contact Us Home
T-cell membrane protein (TIRC7), peptides and antibodies derived therefrom and uses thereof

Image Number 3 for United States Patent #7931901.

Described are generally a T cell immune response cDNA 7 (TIRC7) encoding a novel T-cell transmembrane protein as well as peptides und polypeptides derived therefrom and antibodies recognizing said (poly)peptides. More particularly, peptide and polypeptide as well as antibodies being capable of inhibiting T-cell stimulation through the T-cell membrane protein (TIRC7) are provided. Furthermore, vectors comprising the aforementioned polynucleotides and host cells transformed therewith as well as their use in the production of the above-defined proteins, peptides or polypeptides are described. Additionally, pharmaceutical and diagnostic compositions are provided comprising any one of the afore described polynucleotide, vector, protein, peptide, polypeptide, or antibody. Furthermore, methods and uses for modulating immune responses through the novel TIRC7 membrane protein as well as pharmaceutical compositions comprising agents which act on the TIRC7 membrane protein or its ligand are described. Also, the use of said polynucleotide, vector, protein, peptide, polypeptide, or antibody for the preparation of pharmaceutical compositions for use in organ transplantation, for the treatment of autoimmune, allergic or infectious diseases, or for treatment of tumors is provided. Furthermore, methods for modulating (antigen-specific) T cell unresponsiveness inducing maintaining or reversing T cell unresponsiveness by inhibiting or stimulating an (unresponsive) T cell through the novel TIRC7 membrane protein are encompassed herein.

  Recently Added Patents
System, device and method for transrating file based assets
Control device with adjusting pulse width modulation function and the backlight module thereof
Stereoscopic editing for video production, post-production and display adaptation
Cell reselection and handover with multimedia broadcast/multicast service
System for alarming upon occurrence of secession of smart key for vehicles
Methods and apparatuses for configuring and operating graphics processing units
  Randomly Featured Patents
Transition duct for centrifugal fan
Heat fixing device for a copying machine
Method of making tubular bag
Spatial stablization of standing capillary surface waves
Horticultural pot
CrB.sub.2 -NbB.sub.2 /Al.sub.2 0.sub.3 and CrB.sub.2 -NbB.sub.2 /SiC ceramic composite materials
Computerized portable pneumatic target apparatus
Shielded modular adapter
Cascaded control of an average value of a process parameter to a desired value
Diamine carboxylates and lubricant and fuel compositions containing same