Resources Contact Us Home
Adenovirus/alphavirus hybrid vector for the effective administration and expression of therapeutic genes in tumour cells

Image Number 17 for United States Patent #7850957.

The present invention relates to a genic expression adenoviral hybrid vector characterized in that it contains at least the following elements, oriented in the direction 5' to 3': i. a first chain of adenoviral origin comprising a first inverted terminal repeat (ITR) sequence and a signal sequence for packaging of the adenovirus; ii. a first non-encoding stuffer sequence; iii. a sequence corresponding to a tissue specific promoter; iv. a chain of cDNA derived from an alphavirus, the sequence of which is partly complementary to an alphaviral RNA sequence, comprising at least a sequence encoding for at least one exogenous gene of interest; v. a polyadenylation sequence; and vi. a second adenoviral inverted terminal repeat (ITR) sequence, it preferably relates to an adenoviral hybrid vector comprising as exogenous gene of interest the therapeutic gene of mammalian interleukin IL-12 and even more preferably human interleukin hIL-12; and to the use of the hybrid vector in a process for transferring genetic material to a cell, particularly a tumor cell that preferably expresses alpha-fetoprotein (AFP), and to its use for inducing an immune response against foreign antigens.

  Recently Added Patents
Sample holder and method for treating sample material
Self-correcting amplifier system
Advanced CAPTCHA using images in sequence
Optical article including an antireflecting coating having antifog properties and process for making same
Stand for food service
Methods and system for providing drug pricing information from multiple pharmacy benefit managers (PBMs)
Message value indicator
  Randomly Featured Patents
p38 MAP kinase inhibitors
Light fixture
Printing system, printing apparatus, information processing apparatus, control method therefor, and computer-readable memory
Wiring conductor, method for fabricating same, terminal connecting assembly, and Pb-free solder alloy
Rotary drum for a gear control device for a motor-vehicle gearbox and a gear control device for a motor-vehicle gearbox having such a drum
Method of mounting a camshaft on the cylinder head of an internal combustion engine
Ear canal electrode
Dynamic configuration of unified messaging state changes
Industrial colorimeter having light intensity compensation means
Process for the synthesis of a silica enriched crystalline aluminosilicate having the offretite structure, the aluminosilicate obtained and its use as a catalyst for the conversion of hydrocar