Resources Contact Us Home
Adenovirus/alphavirus hybrid vector for the effective administration and expression of therapeutic genes in tumour cells

Image Number 13 for United States Patent #7850957.

The present invention relates to a genic expression adenoviral hybrid vector characterized in that it contains at least the following elements, oriented in the direction 5' to 3': i. a first chain of adenoviral origin comprising a first inverted terminal repeat (ITR) sequence and a signal sequence for packaging of the adenovirus; ii. a first non-encoding stuffer sequence; iii. a sequence corresponding to a tissue specific promoter; iv. a chain of cDNA derived from an alphavirus, the sequence of which is partly complementary to an alphaviral RNA sequence, comprising at least a sequence encoding for at least one exogenous gene of interest; v. a polyadenylation sequence; and vi. a second adenoviral inverted terminal repeat (ITR) sequence, it preferably relates to an adenoviral hybrid vector comprising as exogenous gene of interest the therapeutic gene of mammalian interleukin IL-12 and even more preferably human interleukin hIL-12; and to the use of the hybrid vector in a process for transferring genetic material to a cell, particularly a tumor cell that preferably expresses alpha-fetoprotein (AFP), and to its use for inducing an immune response against foreign antigens.

  Recently Added Patents
Electronic device, communication control method of electronic device, and information terminal device
Distortion compensation device, distortion compensation method, and radio transmitter
Unified recovery
Device for preparing a body fluid for a bacteriological analysis
Pizza stone
Digital image processing device and processing method thereof
Thermosensitive recording medium
  Randomly Featured Patents
Decorative sleeve for covering a flower pot
Reciprocating piston machine
Infrared hookswitch for a telephone
Insecticide-impregnated fabric and method of production
Flame retardant compositions of halogen-free polymers containing cyclic phosphate or thiophosphate flame retardants
Drive axle assembly having a ring gear adjustably secured to a differential case
CDC37 cell-cycle regulatory protein, and uses related thereto
Ironing board and ladder combination
Process for the in-situ detoxification of aminoalkyl phosphonothiolates by hydrolysis
Electric baseboard heater facade