Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Adenovirus/alphavirus hybrid vector for the effective administration and expression of therapeutic genes in tumour cells










Image Number 11 for United States Patent #7850957.

The present invention relates to a genic expression adenoviral hybrid vector characterized in that it contains at least the following elements, oriented in the direction 5' to 3': i. a first chain of adenoviral origin comprising a first inverted terminal repeat (ITR) sequence and a signal sequence for packaging of the adenovirus; ii. a first non-encoding stuffer sequence; iii. a sequence corresponding to a tissue specific promoter; iv. a chain of cDNA derived from an alphavirus, the sequence of which is partly complementary to an alphaviral RNA sequence, comprising at least a sequence encoding for at least one exogenous gene of interest; v. a polyadenylation sequence; and vi. a second adenoviral inverted terminal repeat (ITR) sequence, it preferably relates to an adenoviral hybrid vector comprising as exogenous gene of interest the therapeutic gene of mammalian interleukin IL-12 and even more preferably human interleukin hIL-12; and to the use of the hybrid vector in a process for transferring genetic material to a cell, particularly a tumor cell that preferably expresses alpha-fetoprotein (AFP), and to its use for inducing an immune response against foreign antigens.








 
 
  Recently Added Patents
Method of manufacturing semiconductor devices using ion implantation
Resistor and manufacturing method thereof
Cardiac function management integrating cardiac contractility modulation
Quinoid thiophene organic photoelectric material, preparation method thereof and application thereof
Deadline-driven parallel execution of queries
Etching apparatus and methods
Method, preprocessor, speech recognition system, and program product for extracting target speech by removing noise
  Randomly Featured Patents
Photon assisted tunneling testing of passivated integrated circuits
Steerable catheter and methods of making the same
Self-marking measuring tape
Semiconductor laser
System and method for reassigning a storage location for reconstructed data on a persistent medium storage system
LED lighting arrangement
Device and method for detecting vehicle engine pulse generator plate tooth defects
Ring
Magnetic random access memory
Method for producing optically active alcohols from alkanones using a dehydrogenase of azoarcus