Resources Contact Us Home
Purine derivatives as A3 and A1 adenosine receptor agonists

Image Number 5 for United States Patent #7825126.

Disclosed are (N)-methanocarba adenine nucleosides of the formula: ##STR00001## as highly potent A.sub.3 adenosine receptor agonists, pharmaceutical compositions comprising such nucleosides, and a method of use of these nucleosides, wherein R.sub.1-R.sub.6 are as defined in the specification. These nucleosides are contemplated for use in the treatment a number of diseases, for example, inflammation, cardiac ischemia, stroke, asthma, diabetes, and cardiac arrhythmias. The invention also provides compounds that are agonists of both A.sub.1 and A.sub.3 adenosine receptors for use in cardioprotection.

  Recently Added Patents
Prevention and treatment of oxidative stress disorders by gluthathione and phase II detoxification enzymes
Polymers derived from benzobis(silolothiophene) and their use as organic semiconductors
Method of manufacturing crystalline silicon solar cells with improved surface passivation
Serial transmission system including transmitter apparatus and receiver apparatus, for use in transmission of AV data
Acrylic pressure-sensitive adhesive composition, acrylic pressure-sensitive adhesive layer, and acrylic pressure-sensitive adhesive tape
Pet cremation urn
Method and apparatus for token-based context caching
  Randomly Featured Patents
Multiplexed input envelope restoration scheme for linear high-efficiency power amplification
Paint container carrier
Method for obtaining and allocating investment income based on the capitalization of intellectual property
Production process for hydroxyalkyl(meth)acrylate
Cooling system for electronic apparatus
Boat guide
Instrument housing
Position and orientation measurement method and position and orientation measurement apparatus
Conductor junctions for medical electrical leads
Medical instrument