Resources Contact Us Home
Purine derivatives as A3 and A1 adenosine receptor agonists

Image Number 5 for United States Patent #7825126.

Disclosed are (N)-methanocarba adenine nucleosides of the formula: ##STR00001## as highly potent A.sub.3 adenosine receptor agonists, pharmaceutical compositions comprising such nucleosides, and a method of use of these nucleosides, wherein R.sub.1-R.sub.6 are as defined in the specification. These nucleosides are contemplated for use in the treatment a number of diseases, for example, inflammation, cardiac ischemia, stroke, asthma, diabetes, and cardiac arrhythmias. The invention also provides compounds that are agonists of both A.sub.1 and A.sub.3 adenosine receptors for use in cardioprotection.

  Recently Added Patents
Hydrating lounge chair
Communication device and method for detecting a radio signal
Epilation apparatus
Image processing apparatus capable of using replacement component, image forming apparatus capable of using replacement component, and method of administrating replacement component
Method for computing an energy efficient route
Center spreader adapter tool for toilet paper rolls and paper towel rolls that do not have inner cardboard tubes
Satellite mounting poles
  Randomly Featured Patents
Cotton candy cart
Polycrystalline ultra-hard compact constructions
Container for medical devices
Pulse width detection circuit filtering the input signal and generating a binary signal
Evaluation apparatus of scientific phenomena, educational tool for scientific experiments and method of manufacturing the same
Pump head
Treatment of ulcerative colitis with tropomyosin isoforms and monoclonal antibodies to tropomyosin isoforms
Method for the preparation of .alpha.-tetralone
Contaminant removal method for a body of water
Substrate processing method and apparatus