Resources Contact Us Home
Purine derivatives as A3 and A1 adenosine receptor agonists

Image Number 5 for United States Patent #7825126.

Disclosed are (N)-methanocarba adenine nucleosides of the formula: ##STR00001## as highly potent A.sub.3 adenosine receptor agonists, pharmaceutical compositions comprising such nucleosides, and a method of use of these nucleosides, wherein R.sub.1-R.sub.6 are as defined in the specification. These nucleosides are contemplated for use in the treatment a number of diseases, for example, inflammation, cardiac ischemia, stroke, asthma, diabetes, and cardiac arrhythmias. The invention also provides compounds that are agonists of both A.sub.1 and A.sub.3 adenosine receptors for use in cardioprotection.

  Recently Added Patents
Advertisement in operating system
Personalized dashboard architecture for displaying data display applications
Meter socket cabinet
Mask blank, transfer mask, and film denseness evaluation method
Equipment to facilitate money transfers into bank accounts
Code conversion apparatus, code conversion method, and computer product
Floor standing rack
  Randomly Featured Patents
Sewing machine with a presser foot mechanism
Alcohol-free transdermal insulin composition and processes for manufacture and use thereof
Front mounted rotary hay rake
Aqueous dispersions of new amphiphilic co-oligomers for the washing- and cleaning-resistant oiling of leather and skins and their use
EDC draft force based ride controller
Chromatographic method of purifying cyclitols
Nuclear densometer
Shield connection
Soybean cultivar S07-03KL016279