Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer










Image Number 16 for United States Patent #7619000.

Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.








 
 
  Recently Added Patents
Bitter taste receptors
Motorized home appliance door
Water slide
Determination of statistical upper bound for estimate of noise power spectral density
Information processing apparatus, non-transitory computer-readable recording medium, and information processing method
Wine cellar alarm system
Transmitter having a programmable amplifier operating class
  Randomly Featured Patents
Magnetic capture docking mechanism
Container cover
Computer monitor bezel
Source follower circuit
Dynamic mode nano-scale imaging and position control using deflection signal direct sampling of higher mode-actuated microcantilevers
Bleaching compositions
Load-resisting truss segments for buildings
Holder/dispenser for paper in roll form
Pulsed signal transition delay adjusting circuit
Divalent metal salts of O,S-dialkyl-N-alkanoylphosphoroamidothioates