Resources Contact Us Home
S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer

Image Number 15 for United States Patent #7619000.

Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.

  Recently Added Patents
System and method for evaluating equipment rack cooling performance
Pelvic registration device for medical navigation
Method for generating optical codes for a print-context
Method for indicating the process of leaving a parking space
Efficient file system metadata scanning using scoped snapshots
Carbon dioxide capture system and methods of capturing carbon dioxide
Permeable pressure sensitive adhesive
  Randomly Featured Patents
Organophilic clay gellants and process for preparation
Vacuum cleaner
Data processor
Enclosure for wireless base stations
Staple gun
Apparatus and method for constructing a spray in place structure
Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
Vehicle stadium/slide seat system
Z-shape cast strand withdrawal and straightening unit for continuous casting machine
Vehicle vicinity-monitoring apparatus