Resources Contact Us Home
S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer

Image Number 15 for United States Patent #7619000.

Arsenic trioxide, an inorganic compound, is commercially available anti-cancer agent but it carries significant toxicity. Organic arsenicals, on the other hand, are much less toxic, to the extent that the methylation of inorganic arsenic in vivo into organic arsenicals has been considered a detoxification reaction. New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia. Results form a basis for the development of S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid, S-dimethylarsino-thiobenzoic acid, and other organic arsenicals as an anti-cancer therapy, combining high efficacy with very low, if any, toxicity.

  Recently Added Patents
Method, medium, and system compressing and/or reconstructing image information with low complexity
Method of light dispersion and preferential scattering of certain wavelengths of light for light-emitting diodes and bulbs constructed therefrom
Metformin glycinate salt for blood glucose control
Contour-mode piezoelectric micromechanical resonators
Adaptive data recovery system with input signal equalization
Current sensor including a sintered metal layer
Multi-label modeling using a plurality of classifiers
  Randomly Featured Patents
Dice cup
System and method for three-dimensional interleaved water and fat image acquisition with chemical-shift correction
Laser pulse stretcher and compressor with single parameter wavelength tunability
EP print media path actuated by insertion/removal of toner cartridge
Electromagnetic planar diaphragm transducer
Variable-length code decoding apparatus and method
Portable electronic device
Rigid polymeric cutting article, a rotary tool having the article attached thereto, and a method of using
Combination steamer and convection oven with double doors
Multi-layer polyelectrolyte membrane