Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
CA IX-specific inhibitors










Image Number 6 for United States Patent #7550424.

Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Screening assays are provided for identifying compounds, preferably membrane-impermeant compounds, which inhibit the enzymatic activity of MN protein/polypeptides and that are useful for treating patients with preneoplastic/neoplastic disease. Further methods are disclosed for the preparation of positively-charged, membrane-impermeant heterocyclic sulfonamide CA inhibitors with high affinity for the membrane-bound carbonic anhydrase CA IX. Preferred CA IX-specific inhibitors are aromatic and heterocylic sulfonamides, preferably that are membrane-impermeant. Particularly preferred CA IX-specific inhibitors are pyridinium derivatives of such aromatic and heterocyclic sulfonamides. The CA IX-specific inhibitors of the invention can also be used diagnostically/prognostically for preneoplastic/neoplastic disease, and for imaging use, for example, to detect precancerous cells, tumors and/or metastases. The CA IX-specific inhibitors can be labelled or conjugated to radioisotopes for radiotherapy. The CA IX-specific inhibitors may be combined with conventional therapeutic anti-cancer drugs, with other different inhibitors of cancer-related pathways, with bioreductive drugs, or with radiotherapy to enhance the efficiency of each treatment. The CA IX-specific inhibitors may also be combined with CA IX-specific antibodies, preferably monoclonal antibodies or biologically active antibody fragments, more preferably humanized or fully human CA IX monoclonal antibodies or biologically active fragments or such monoclonal antibodies. Still further, the CA IX-specific inhibitors can be used for gene therapy coupled to vectors for targeted delivery to preneoplastic/neoplastic cells expressing CA IX on their surfaces.








 
 
  Recently Added Patents
Low-coupling oxide media (LCOM)
Method and system for automatic 3-D image creation
Method and system for calibrating laser profiling systems
Fluid handling structure, a lithographic apparatus and a device manufacturing method
Scalable architecture for rank order filtering
Housekeeping cart
Representing polarized light in computer models
  Randomly Featured Patents
Fluoroelastomers with improved low temperature property and method for making the same
Method of reducing spurious signal generation in passive microwave components
Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions
Minimizing configuration changes in a fabric-based data protection solution
Composite semiconductor device, LED head that employs the composite semiconductor device, and image forming apparatus that employs the LED head
Knockdown canopy shelter
Down-conversion mixer with signal processing
Apparatus and method for accessing plural storage devices in predetermined order by slot allocation
Storage apparatus and method of data processing
Method of two dimensional feature model calibration and optimization