Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
CA IX-specific inhibitors










Image Number 6 for United States Patent #7550424.

Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Screening assays are provided for identifying compounds, preferably membrane-impermeant compounds, which inhibit the enzymatic activity of MN protein/polypeptides and that are useful for treating patients with preneoplastic/neoplastic disease. Further methods are disclosed for the preparation of positively-charged, membrane-impermeant heterocyclic sulfonamide CA inhibitors with high affinity for the membrane-bound carbonic anhydrase CA IX. Preferred CA IX-specific inhibitors are aromatic and heterocylic sulfonamides, preferably that are membrane-impermeant. Particularly preferred CA IX-specific inhibitors are pyridinium derivatives of such aromatic and heterocyclic sulfonamides. The CA IX-specific inhibitors of the invention can also be used diagnostically/prognostically for preneoplastic/neoplastic disease, and for imaging use, for example, to detect precancerous cells, tumors and/or metastases. The CA IX-specific inhibitors can be labelled or conjugated to radioisotopes for radiotherapy. The CA IX-specific inhibitors may be combined with conventional therapeutic anti-cancer drugs, with other different inhibitors of cancer-related pathways, with bioreductive drugs, or with radiotherapy to enhance the efficiency of each treatment. The CA IX-specific inhibitors may also be combined with CA IX-specific antibodies, preferably monoclonal antibodies or biologically active antibody fragments, more preferably humanized or fully human CA IX monoclonal antibodies or biologically active fragments or such monoclonal antibodies. Still further, the CA IX-specific inhibitors can be used for gene therapy coupled to vectors for targeted delivery to preneoplastic/neoplastic cells expressing CA IX on their surfaces.








 
 
  Recently Added Patents
Composition comprising a mixture of dextro- and levo-amphetamines complexed with ion-exchange resin particles to form drug resin particles
System and method for generating profile morphing using cephalometric tracing data
Pose-variant face recognition using multiscale local descriptors
Audio/video program-related hyperlink printer
Traveling vehicle system and self-diagnosis method for the traveling vehicle system
Plural component proportioner
Planarizing agents and devices
  Randomly Featured Patents
High molecular weight polycarbonates of .alpha.,.alpha.,.alpha.,.alpha.',.alpha.',.alpha.'-hexakisaryl-1,3-and/o r -1,4-dimethyl benzenes
Trailer hitch accessory mount
Cosmetic composition with soft focus properties
Preparation of pure N-vinyl-2-pyrrolidone
Fast gamma camera
Method for setting cyclic shift considering frequency offset
Highly durable polymer electrolytic membrane for a fuel cell having a cross-linked structure
Printer
Lottery number picker kit
Pneumatic constant-velocity running apparatus