Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
CA IX-specific inhibitors










Image Number 6 for United States Patent #7550424.

Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Screening assays are provided for identifying compounds, preferably membrane-impermeant compounds, which inhibit the enzymatic activity of MN protein/polypeptides and that are useful for treating patients with preneoplastic/neoplastic disease. Further methods are disclosed for the preparation of positively-charged, membrane-impermeant heterocyclic sulfonamide CA inhibitors with high affinity for the membrane-bound carbonic anhydrase CA IX. Preferred CA IX-specific inhibitors are aromatic and heterocylic sulfonamides, preferably that are membrane-impermeant. Particularly preferred CA IX-specific inhibitors are pyridinium derivatives of such aromatic and heterocyclic sulfonamides. The CA IX-specific inhibitors of the invention can also be used diagnostically/prognostically for preneoplastic/neoplastic disease, and for imaging use, for example, to detect precancerous cells, tumors and/or metastases. The CA IX-specific inhibitors can be labelled or conjugated to radioisotopes for radiotherapy. The CA IX-specific inhibitors may be combined with conventional therapeutic anti-cancer drugs, with other different inhibitors of cancer-related pathways, with bioreductive drugs, or with radiotherapy to enhance the efficiency of each treatment. The CA IX-specific inhibitors may also be combined with CA IX-specific antibodies, preferably monoclonal antibodies or biologically active antibody fragments, more preferably humanized or fully human CA IX monoclonal antibodies or biologically active fragments or such monoclonal antibodies. Still further, the CA IX-specific inhibitors can be used for gene therapy coupled to vectors for targeted delivery to preneoplastic/neoplastic cells expressing CA IX on their surfaces.








 
 
  Recently Added Patents
Load balancing for parallel tasks
Nonaqueous secondary battery with nitrile group-containing compound
Obviation of recovery of data store consistency for application I/O errors
System and method for detecting an earth ground fault of an external power supply connected to a vehicle
Information retrieval system, information retrieval method, and information retrieval program
Vehicles with electric motor
Method and apparatus for disease diagnosis and screening using extremely low frequency electromagnetic fields
  Randomly Featured Patents
Roller transducer apparatus
Peripheral device of a portable computer with thermal control circuitry
Telechelic polymers and heterotelechelic polydiene block polymers with dual cure systems
Sewing machine
Device for in-line surface-hardening of products
Liquid level sensing switch
Fishing reel
Print control apparatus and method for printing images on a continuous sheet
Method for mitigating leakage currents
Manufacturing method of electronic circuit including multilayer circuit board