Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
CA IX-specific inhibitors










Image Number 6 for United States Patent #7550424.

Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Screening assays are provided for identifying compounds, preferably membrane-impermeant compounds, which inhibit the enzymatic activity of MN protein/polypeptides and that are useful for treating patients with preneoplastic/neoplastic disease. Further methods are disclosed for the preparation of positively-charged, membrane-impermeant heterocyclic sulfonamide CA inhibitors with high affinity for the membrane-bound carbonic anhydrase CA IX. Preferred CA IX-specific inhibitors are aromatic and heterocylic sulfonamides, preferably that are membrane-impermeant. Particularly preferred CA IX-specific inhibitors are pyridinium derivatives of such aromatic and heterocyclic sulfonamides. The CA IX-specific inhibitors of the invention can also be used diagnostically/prognostically for preneoplastic/neoplastic disease, and for imaging use, for example, to detect precancerous cells, tumors and/or metastases. The CA IX-specific inhibitors can be labelled or conjugated to radioisotopes for radiotherapy. The CA IX-specific inhibitors may be combined with conventional therapeutic anti-cancer drugs, with other different inhibitors of cancer-related pathways, with bioreductive drugs, or with radiotherapy to enhance the efficiency of each treatment. The CA IX-specific inhibitors may also be combined with CA IX-specific antibodies, preferably monoclonal antibodies or biologically active antibody fragments, more preferably humanized or fully human CA IX monoclonal antibodies or biologically active fragments or such monoclonal antibodies. Still further, the CA IX-specific inhibitors can be used for gene therapy coupled to vectors for targeted delivery to preneoplastic/neoplastic cells expressing CA IX on their surfaces.








 
 
  Recently Added Patents
Equalizer tap correction and reseeding
Method for enabling a home base station to choose between local and remote transportation of uplink data packets
Audio processing device and method for reducing echo from a second signal in a first signal
Extended width entries for hash tables
System supporting seller's promotion creation
Integrated circuit and method for reducing violations of a timing constraint
Drawer for holding beverage cup
  Randomly Featured Patents
Fill level measuring device working with microwaves
Furniture pull
Therapeutic combination comprising a pulmonary surfactant and antioxidant enzymes
Random access memory having an adaptable latency
Teeter bed zone density control device and method
Method and device for compressing moving image
Semiconductor memory device and method for fabricating the same dynamic random access memory device construction
Adaptive signal latency control for communications systems signals
Digital control system
Tray-fed scanning acoustic microscope system and method for immobilizing parts during inspection