Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
CA IX-specific inhibitors










Image Number 6 for United States Patent #7550424.

Therapeutic methods for inhibiting the growth of preneoplastic/neoplastic vertebrate cells that abnormally express MN protein are disclosed. Screening assays are provided for identifying compounds, preferably membrane-impermeant compounds, which inhibit the enzymatic activity of MN protein/polypeptides and that are useful for treating patients with preneoplastic/neoplastic disease. Further methods are disclosed for the preparation of positively-charged, membrane-impermeant heterocyclic sulfonamide CA inhibitors with high affinity for the membrane-bound carbonic anhydrase CA IX. Preferred CA IX-specific inhibitors are aromatic and heterocylic sulfonamides, preferably that are membrane-impermeant. Particularly preferred CA IX-specific inhibitors are pyridinium derivatives of such aromatic and heterocyclic sulfonamides. The CA IX-specific inhibitors of the invention can also be used diagnostically/prognostically for preneoplastic/neoplastic disease, and for imaging use, for example, to detect precancerous cells, tumors and/or metastases. The CA IX-specific inhibitors can be labelled or conjugated to radioisotopes for radiotherapy. The CA IX-specific inhibitors may be combined with conventional therapeutic anti-cancer drugs, with other different inhibitors of cancer-related pathways, with bioreductive drugs, or with radiotherapy to enhance the efficiency of each treatment. The CA IX-specific inhibitors may also be combined with CA IX-specific antibodies, preferably monoclonal antibodies or biologically active antibody fragments, more preferably humanized or fully human CA IX monoclonal antibodies or biologically active fragments or such monoclonal antibodies. Still further, the CA IX-specific inhibitors can be used for gene therapy coupled to vectors for targeted delivery to preneoplastic/neoplastic cells expressing CA IX on their surfaces.








 
 
  Recently Added Patents
Combination of the application of antibodies for immunostimulation together with glucocorticoids
Motion estimation for a video transcoder
Method for adapting a contact point of a clutch in a drivetrain of a motor vehicle
Ice data collection system
Shoe bag
Method for measuring and improving organization effectiveness
Motor control system, motor control device, and brushless motor
  Randomly Featured Patents
Processing tool for a road surface processing machine
Tamper barrier for electronic device
Method and device for controlling the slippage of a vehicle wheel
Sports stick handle
Apparatus for connecting semiconductor devices to wiring boards
System with multiple path fail over, fail back and load balancing
Devices for controlling a speed restriction for vehicles, particularly motor vehicles
Daily task and memory assistance using a mobile device
Method of producing bearings
Method, device system and computer program system for processing document data