Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Methods of inhibiting IL-2 production by T cells by administering 7C10 and 16C10 CD80-specific antibodies










Image Number 12 for United States Patent #7491393.

The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 receptor. Two of these antibodies, 16C10 and 7C10, significantly inhibit the production of IL-2, in spite of the existence of a second activating ligand B7.2 (CD86). Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 and/or B7.2 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signalling. These antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.








 
 
  Recently Added Patents
Auto-provisioning of network services over an Ethernet access link
Solid-state imaging device
Multilayered material sheet and process for its preparation
Placental tissue grafts
Method and apparatus for belling plastic pipe
Computerized apparatus for identifying industries for potential transfer of a job function
Contactless electrical connector for an induction sensor, and sensor including such a connector
  Randomly Featured Patents
Electric pencil sharpener
Method for manufacturing a housing
Reconfiguring propagation streams in distributed information sharing
Method for disposal of sodium waste material
Immunostimulant compositions comprising an aminoalkyl glucosaminide phosphate and QS-21
Lock for magnetic tape reel shipping case
Digital fluid flow control system
Wardrobe
Membrane process for separating gases from gas-liquid charge streams
Process of making naphthoquinone diazide esters using lactone solvents