Resources Contact Us Home
Methods of inhibiting IL-2 production by T cells by administering 7C10 and 16C10 CD80-specific antibodies

Image Number 12 for United States Patent #7491393.

The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 receptor. Two of these antibodies, 16C10 and 7C10, significantly inhibit the production of IL-2, in spite of the existence of a second activating ligand B7.2 (CD86). Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 and/or B7.2 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signalling. These antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.

  Recently Added Patents
Method for producing organo-oligo silsesquioxanes
Remote device pairing setup
Flat panel crystal display employing simultaneous charging of main and subsidiary pixel electrodes
Method for treating oncological diseases
Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
Packet communication system and packet communication method, and node and user device
Device, information processing method, and computer-readable storage medium
  Randomly Featured Patents
Treatment system for waste water
Method and apparatus pertaining to the assessment of mobile communications network infrastructure latency through high-speed channels
Display device, method of driving display device, and program
Seat cushion extension mechanism
Robotic apparatuses, systems and methods
Pressurized container and method of filling it
Milk frother
Method and apparatus for ink jet printing on rigid panels
Semiconductor device for controlling a delay time of an output signal of a PLL
Compressor bleed manifold for a gas turbine engine