Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Methods of inhibiting IL-2 production by T cells by administering 7C10 and 16C10 CD80-specific antibodies










Image Number 12 for United States Patent #7491393.

The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 receptor. Two of these antibodies, 16C10 and 7C10, significantly inhibit the production of IL-2, in spite of the existence of a second activating ligand B7.2 (CD86). Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 and/or B7.2 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signalling. These antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.








 
 
  Recently Added Patents
Microwavable bag
Controlling generation of debug exceptions
Method of manufacturing semiconductor device
Semiconductor device with an amorphous semi-insulating layer, temperature sensor, and method of manufacturing a semiconductor device
Materials for organic electroluminescent devices containing substituted 10-benzo[c]phenanthrenes
Listing recommendation using generation of a user-specific query in a network-based commerce system
Granulated sweetening composition
  Randomly Featured Patents
Portable phone
Method and device in a paper machine, coating machine, intermediate winder, unwind stand of a slitter-winder, or in any other device for treatment of a web
Semiconductor memory device for internally controlling strength of output driver
Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
Spray-suppressant splash guard for vehicles
Nonvolatile semiconductor memory device
High solids ethylene vinyl acetate emulsions
Cooled journal bearing
Garment bag system
Spatial averaging technique for ellipsometry and reflectometry