Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Methods of inhibiting IL-2 production by T cells by administering 7C10 and 16C10 CD80-specific antibodies










Image Number 12 for United States Patent #7491393.

The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 receptor. Two of these antibodies, 16C10 and 7C10, significantly inhibit the production of IL-2, in spite of the existence of a second activating ligand B7.2 (CD86). Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 and/or B7.2 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signalling. These antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.








 
 
  Recently Added Patents
Music composition automation including song structure
System and method for configuring software applications in a motor vehicle
Method and system for physical verification using network segment current
Light-reflective anisotropic conductive paste and light-emitting device
Wound dressing with a discontinuous contact layer surface
Combination for composite layered chip package
Providing multiple decode options for a system-on-chip (SoC) fabric
  Randomly Featured Patents
Forming a retrograde well in a transistor to enhance performance of the transistor
Molecules of the PYRIN/NBS/LRR protein family and uses thereof
Bale forming apparatus
Omni-wheel based driving device with enhanced main wheel structure
Method and apparatus for mitigating VCO pulling
Arrangement for improving availability of services in a communication system
Method and device for the automatic detection of surface defects for continuously cast products with continuous mechanical removal of the material
Dishwasher providing usage guidance
Baseball bunting target
Pig receiver assembly