Resources Contact Us Home
Compositions and methods for non-targeted activation of endogenous genes

Image Number 14 for United States Patent #7419828.

The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods for expressing an endogenous gene in a cell at levels higher than those normally found in the cell. In one embodiment of the invention, expression of an endogenous gene is activated or increased following integration into the cell, by non-homologous or illegitimate recombination, of a regulatory sequence that activates expression of the gene. The invention also provides methods for the identification, activation, isolation, and/or expression of genes undiscoverable by current methods since no target sequence is necessary for integration. The invention is specifically directed to methods of drug discovery using the activated gene products for compound testing.

  Recently Added Patents
Noise suppression in speech signals
Molecular sieve
Bicyclic azaheterocyclic carboxamides
LED illumination control using a simple digital command structure
Instance management of code in a database
Synchronous rectifier network unit circuit and method
Magnetic resonance imaging apparatus
  Randomly Featured Patents
Refuse packer assembly
Thermal management system
Superjunction semiconductor device
Stabilized color television subcarrier regenerator circuit
Combination light fixture and lens assembly
Content-indexing search system and method providing search results consistent with content filtering and blocking policies implemented in a blocking engine
Hermetic cap layers formed on low-.kappa. films by plasma enhanced chemical vapor deposition
Controlled-release formulations of interleukin-2
Diamond cut