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Chimeric and humanized antibodies to .alpha.5.beta.1 integrin that modulate angiogenesis

Image Number 18 for United States Patent #7285268.

The present invention provides chimeric and humanized antibodies that specifically recognize .alpha.5.beta.1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.

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