Resources Contact Us Home
Short amphipathic peptides with activity against bacteria and intracellular pathogens

Image Number 3 for United States Patent #7262163.

"Minimalist" antimicrobial peptides are disclosed based on 50 to 80% .alpha.,.alpha.-dialkylated amino acids. The peptides are short, cationic, amphipathic, and possess a high helix propensity. Polar .alpha.,.alpha.-dialkylated amino acids are also disclosed. These peptides are easy and inexpensive to synthesize via solid-phase techniques. The peptides exhibit in vitro anti-bacterial properties at concentrations that are not lethal to normal mammalian cells. The peptides exhibit in vivo bioactivity against intracellular pathogens.

  Recently Added Patents
Method for mapping resource units
Transfer of digital data through an isolation
Hydrating lounge chair
Controller interface providing improved data reliability
Phospholipid-based powders for drug delivery
Cell reselection and handover with multimedia broadcast/multicast service
Plants and seeds of hybrid corn variety CH514730
  Randomly Featured Patents
Grapevine, "American Rose"
Maximum-likelihood symbol detection for RLL-coded data
Method of determining fuel injector performance in-chassis and electronic control module using the same
Memory chip architecture having non-rectangular memory banks and method for arranging memory banks
Ceiling fan
Coupling construction
Material for, and method of forming, tubular walls for product containers
Worktable for sawing machine
In-pipe hydro-electric power system and turbine
Text processing system including plural text and corresponding memories