Resources Contact Us Home
Short amphipathic peptides with activity against bacteria and intracellular pathogens

Image Number 3 for United States Patent #7262163.

"Minimalist" antimicrobial peptides are disclosed based on 50 to 80% .alpha.,.alpha.-dialkylated amino acids. The peptides are short, cationic, amphipathic, and possess a high helix propensity. Polar .alpha.,.alpha.-dialkylated amino acids are also disclosed. These peptides are easy and inexpensive to synthesize via solid-phase techniques. The peptides exhibit in vitro anti-bacterial properties at concentrations that are not lethal to normal mammalian cells. The peptides exhibit in vivo bioactivity against intracellular pathogens.

  Recently Added Patents
Catheter with multiple electrode assemblies for use at or near tubular regions of the heart
Method and system for video parameter analysis and transmission
Optical article including an antireflecting coating having antifog properties and process for making same
Moving structure and micro-mirror device using the same
System and method for deposition in high aspect ratio magnetic writer heads
Push mechanism for efficiently sending aggregated data items to client
Network decoys
  Randomly Featured Patents
DNA encoding mammalian retinol binding protein receptor, and corresponding vectors and transformed cells
Automotive air conditioner
Frame and data pattern structure for multi-carrier systems
C-.beta.-D-Xylopyranoside series compounds
Method for low-voltage termination of cardiac arrhythmias by effectively unpinning anatomical reentries
Container for medications and the like including locking device
Casting steel strip
Waste system for toilets
Switching device for an on-load tap changer
Christmas tree ornament platform