Resources Contact Us Home
Inhibitors of memapsin 2 and use thereof

Image Number 6 for United States Patent #7244708.

Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been determined and were used to design substrate analogs of the natural -2 substrate that can inhibit the function of memapsin 2. Processes for the synthesis of two substrate analogues including isosteres at the sites of the critical amino acid residues were developed and the substrate analogues, OMR99-1 and OM99-2, were synthesized. The inhibition constant of OM99-2 is 1.6.times.10.sup.-9 M against recombinant pro-memapsin 2. Crystallography of memapsin 2 bound to this inhibitor was used to determine the three dimensional structure of the protein, and the importance of the various residues in binding. This information is useful for designing new inhibitors to memapsin 2, for diagnosing and treating and/or preventing Alzheimer's disease.

  Recently Added Patents
Code reading apparatus, sales registering apparatus, and sales registering method
Method for accessing wireless network
Information terminal, setting information distribution server, right information distribution server, network connection setting program and method
Method and system for dynamically representing distributed information
Methods and apparatus for monitoring communication through identification of priority-ranked keywords
Antenna arrangement and antenna housing
Bipolar junction transistor with a self-aligned emitter and base
  Randomly Featured Patents
Overhead-supported net system
Low optical dot gain color proof composites
Electronic lock input dial
Method for error correction and error detection of binary data
Balance training apparatus
Image capturing apparatus
Flame-retardant molded component
Slat conveyor chain
Control system using combined closed loop and duty cycle control functions
Carburetor for internal combustion engines, especially very small portable engines