Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inhibitors of memapsin 2 and use thereof










Image Number 15 for United States Patent #7244708.

Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been determined and were used to design substrate analogs of the natural -2 substrate that can inhibit the function of memapsin 2. Processes for the synthesis of two substrate analogues including isosteres at the sites of the critical amino acid residues were developed and the substrate analogues, OMR99-1 and OM99-2, were synthesized. The inhibition constant of OM99-2 is 1.6.times.10.sup.-9 M against recombinant pro-memapsin 2. Crystallography of memapsin 2 bound to this inhibitor was used to determine the three dimensional structure of the protein, and the importance of the various residues in binding. This information is useful for designing new inhibitors to memapsin 2, for diagnosing and treating and/or preventing Alzheimer's disease.








 
 
  Recently Added Patents
Generalized AC-DC synchronous rectification techniques for single- and multi-phase systems
Thiocyanato or isothiocyanato substituted naphthalene diimide and rylene diimide compounds and their use as n-type semiconductors
Wafer level packaging structure with large contact area and preparation method thereof
RFID reader revocation checking using low power attached displays
Method and system for modifying satellite radio program subscriptions in a mobile vehicle
Lithographic apparatus and device manufacturing method
Products for animal use including humans having a certificate verifying at least one of efficacy or safety, and methods of providing such certificates
  Randomly Featured Patents
Rotor assembly end turn cooling system and method
System and method for localization of sounds in three-dimensional space
Dual pressure preload system for maintaining a member
Balloon cones and waists thinning methodology
Method for selective dehalogenation of halogenated polyaromatic compounds
Ink drop character line printer with traversing orifice band
Virtual white lines (VWL) for delimiting planned excavation sites of staged excavation projects
System and methods of updating compact discs and graphical user interface for updating same
Rigging and sail system for sailboat
Self-inflatable air cushion