Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Inhibitors of memapsin 2 and use thereof










Image Number 10 for United States Patent #7244708.

Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been determined and were used to design substrate analogs of the natural -2 substrate that can inhibit the function of memapsin 2. Processes for the synthesis of two substrate analogues including isosteres at the sites of the critical amino acid residues were developed and the substrate analogues, OMR99-1 and OM99-2, were synthesized. The inhibition constant of OM99-2 is 1.6.times.10.sup.-9 M against recombinant pro-memapsin 2. Crystallography of memapsin 2 bound to this inhibitor was used to determine the three dimensional structure of the protein, and the importance of the various residues in binding. This information is useful for designing new inhibitors to memapsin 2, for diagnosing and treating and/or preventing Alzheimer's disease.








 
 
  Recently Added Patents
Synchronization scheduling apparatus and method in real-time multi-core system
Compounds for the reduction of .beta.-amyloid production
Multiple-frequency inversion method and control apparatus for internal combustion engine driven generator
Sperm factor sequences
System and method for outputting virtual textures in electronic devices
Imidazole-5-carboxylic acid derivatives, the preparation method therefor and the uses thereof
Planarizing agents and devices
  Randomly Featured Patents
Audio variance for multiple windows
Hydrolysis of acylamino acids
Charcoal grill
Garment with plurality of access seams
Process for producing cover coated electronic circuits
Low voltage differential dual receiver
Tape deck capstan shifting apparatus
Locking device and a line fitting provided therewith
Scraper
Data strobe signal generator for generating data strobe signal based on adjustable preamble value and semiconductor memory device with the same