Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Phosphonic acid based prodrugs of PMEA and its analogues










Image Number 8 for United States Patent #7214668.

Prodrugs of Formula I, their uses, their intermediates, and their method of manufacture are described: ##STR00001## wherein: M and V are cis to one another and MPO.sub.3H.sub.2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmethoxyethyl)adenine, (R)-9-(2-phosphonylmethoxy propyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, 9-(2-phosphonylmethoxy ethyloxy)adenine, 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine, (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, 9-(3-hydroxy-2-phosphonylmethoxypropyl)guanine, and (S)-9-(3-fluoro-2-phosphonyl methoxypropyl)adenine; V is selected from a group consisting of phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl, 3-furanyl, 2-thienyl, and 3-thienyl, all optionally substituted with 1-3 substituents selected from a group consisting of F, Cl, Br, C1-C3 alkyl, CF.sub.3 and OR.sup.6; R.sup.6 is selected from the group consisting of C1-C3 alkyl, and CF.sub.3; and pharmaceutically acceptable salts thereof.








 
 
  Recently Added Patents
Image sorting device, method, program, and integrated circuit and storage medium storing said program
Sliding-type portable communication device
Substituted indolo 4,3 FG quinolines useful for treating migraine
Vanilloid receptor ligands and use thereof for the production of pharmaceutical preparations
Wristwatch
Headset systems and methods
Apparatus and method for discharging capacitor of input filter of power supply, and power supply including the apparatus
  Randomly Featured Patents
Holding assembly for movable closure element with releasably connected first and second linked elements
Method of machine working marble or granite
Method and apparatus for frequency-domain tracking of residual frequency and channel estimation offsets
System for modeling static and dynamic three dimensional anatomical structures by 3-D models
Wire harness apparatus for multi-node video camera array
Bicycle pedal
Bacteria mixture having heavy oil degrading ability and method of treating oil components
Self-cleaning screen for the cooling air inlet of an engine enclosure
Process for removing alumina or silica substrate from carbonaceous pyropolymers
Musical tone control apparatus and sensing device for electronic musical instrument