Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Phosphonic acid based prodrugs of PMEA and its analogues










Image Number 8 for United States Patent #7214668.

Prodrugs of Formula I, their uses, their intermediates, and their method of manufacture are described: ##STR00001## wherein: M and V are cis to one another and MPO.sub.3H.sub.2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmethoxyethyl)adenine, (R)-9-(2-phosphonylmethoxy propyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, 9-(2-phosphonylmethoxy ethyloxy)adenine, 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine, (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, 9-(3-hydroxy-2-phosphonylmethoxypropyl)guanine, and (S)-9-(3-fluoro-2-phosphonyl methoxypropyl)adenine; V is selected from a group consisting of phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl, 3-furanyl, 2-thienyl, and 3-thienyl, all optionally substituted with 1-3 substituents selected from a group consisting of F, Cl, Br, C1-C3 alkyl, CF.sub.3 and OR.sup.6; R.sup.6 is selected from the group consisting of C1-C3 alkyl, and CF.sub.3; and pharmaceutically acceptable salts thereof.








 
 
  Recently Added Patents
Light-emitting diode package and method for manufacturing the same
Method of manufacturing crystalline silicon solar cells with improved surface passivation
Systems and related methods of user-guided searching
Data storage device and block selection method for a flash memory
Display panel and gate driving circuit and driving method for gate driving circuit
Systems and methods for automobile accident claims initiation
Disk array apparatus and firmware update method therefor
  Randomly Featured Patents
Control device for dosing emulsifiers in chocolate mass
Golf shoe
Low temperature sintered BI2O3-ZNO-NB2O5 ceramics and method for its formation
Projection exposure apparatus and device manufacturing method
Expansion base for notebooks
Pharmaceutical compositions and methods relating to fucans
Liquid spraying cartridge containing a recording liquid having a pH of over 4 and under 6
Select pace golf course
Movable insulation puncher
Dual lumen catheter