Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Phosphonic acid based prodrugs of PMEA and its analogues










Image Number 8 for United States Patent #7214668.

Prodrugs of Formula I, their uses, their intermediates, and their method of manufacture are described: ##STR00001## wherein: M and V are cis to one another and MPO.sub.3H.sub.2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmethoxyethyl)adenine, (R)-9-(2-phosphonylmethoxy propyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, 9-(2-phosphonylmethoxy ethyloxy)adenine, 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine, (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, 9-(3-hydroxy-2-phosphonylmethoxypropyl)guanine, and (S)-9-(3-fluoro-2-phosphonyl methoxypropyl)adenine; V is selected from a group consisting of phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl, 3-furanyl, 2-thienyl, and 3-thienyl, all optionally substituted with 1-3 substituents selected from a group consisting of F, Cl, Br, C1-C3 alkyl, CF.sub.3 and OR.sup.6; R.sup.6 is selected from the group consisting of C1-C3 alkyl, and CF.sub.3; and pharmaceutically acceptable salts thereof.








 
 
  Recently Added Patents
Semiconductor integrated circuit
Wristwatch
Package for product
Externally gapped line arrester
Methods of producing the membranes and the uses of membranes as battery separator films
Tri-material dual-species neutron spectrometer
Encoding method, decoding method, encoding device, decoding device, program, and recording medium
  Randomly Featured Patents
System and method for controlling access to a privileged permission level of a server computer
System and method to manipulate large objects on enterprise server data management system
Side marker lamp mounting assembly
Immunoregulator comprising a derivative of estradiol
Ultrasonic Doppler flowmeter with correction for vibratory signals at zero-flow conditions
Securement of head reset support into automobile seat frame
Liquid rinse cycle fabric softening compositions containing diacid polymeric fatty ester quaternary ammonium compounds
System and method for a multiple merchant stored value card
Method and system for brazing
Argument structure hierarchy system and method for facilitating analysis and decision-making processes