Resources Contact Us Home
Phosphonic acid based prodrugs of PMEA and its analogues

Image Number 8 for United States Patent #7214668.

Prodrugs of Formula I, their uses, their intermediates, and their method of manufacture are described: ##STR00001## wherein: M and V are cis to one another and MPO.sub.3H.sub.2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmethoxyethyl)adenine, (R)-9-(2-phosphonylmethoxy propyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, 9-(2-phosphonylmethoxy ethyloxy)adenine, 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine, (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, 9-(3-hydroxy-2-phosphonylmethoxypropyl)guanine, and (S)-9-(3-fluoro-2-phosphonyl methoxypropyl)adenine; V is selected from a group consisting of phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl, 3-furanyl, 2-thienyl, and 3-thienyl, all optionally substituted with 1-3 substituents selected from a group consisting of F, Cl, Br, C1-C3 alkyl, CF.sub.3 and OR.sup.6; R.sup.6 is selected from the group consisting of C1-C3 alkyl, and CF.sub.3; and pharmaceutically acceptable salts thereof.

  Recently Added Patents
Over the counter medicinal container with surface ornamentation
Electrostatic charger and image forming apparatus
Audiovisual multi-room support
Fuse part in semiconductor device and method for forming the same
Control unit of a ride level control system, and ride level control system
Powder for layerwise manufacturing of objects
Electronic device, information processing method, and storage medium
  Randomly Featured Patents
Separation preventive pipe joint
Ink-jet recording head that minutely vibrates ink meniscus
Continuous pusher furnace having traveling gas barrier
Lift truck control systems
Transition metal acetylide compound, nano-powder and method for producing a transition metal acetylide compound
Portable electric circular saw
Flame arrester
Method of designing a surgical kit for cartilage repair in a joint
Synthesis of conjugated linoleic acid (CLA)
Control system for peck drilling tool