Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Phosphonic acid based prodrugs of PMEA and its analogues










Image Number 8 for United States Patent #7214668.

Prodrugs of Formula I, their uses, their intermediates, and their method of manufacture are described: ##STR00001## wherein: M and V are cis to one another and MPO.sub.3H.sub.2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmethoxyethyl)adenine, (R)-9-(2-phosphonylmethoxy propyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, 9-(2-phosphonylmethoxy ethyloxy)adenine, 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine, (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, 9-(3-hydroxy-2-phosphonylmethoxypropyl)guanine, and (S)-9-(3-fluoro-2-phosphonyl methoxypropyl)adenine; V is selected from a group consisting of phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl, 3-furanyl, 2-thienyl, and 3-thienyl, all optionally substituted with 1-3 substituents selected from a group consisting of F, Cl, Br, C1-C3 alkyl, CF.sub.3 and OR.sup.6; R.sup.6 is selected from the group consisting of C1-C3 alkyl, and CF.sub.3; and pharmaceutically acceptable salts thereof.








 
 
  Recently Added Patents
Managing job execution
Data transfer device and data transfer method
Light-emitting device with a spacer at bottom surface
Authentication method
Materials and methods for stress reduction in semiconductor wafer passivation layers
Image forming apparatus with static elimination
Method of reducing acetaldehyde in polyesters, and polyesters therefrom
  Randomly Featured Patents
Multi-factor authentication
Regiospecific carbonylation process for making acyl compounds from aromatic heterocycles and olefins
Method of making an isolation layer stack semiconductor device
Botulinum toxin screening assays
Object lens actuator, optical pickup and optical disk drive
Auto focusing light device
Apparatus for simultaneously displaying TV and PC images
Coaxial cable connector
Variable permeability magnetic field sensor and method
Memorabilia apparatus