Resources Contact Us Home
Phosphonic acid based prodrugs of PMEA and its analogues

Image Number 8 for United States Patent #7214668.

Prodrugs of Formula I, their uses, their intermediates, and their method of manufacture are described: ##STR00001## wherein: M and V are cis to one another and MPO.sub.3H.sub.2 is a phosphonic acid selected from the group consisting of 9-(2-phosphonylmethoxyethyl)adenine, (R)-9-(2-phosphonylmethoxy propyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, 9-(2-phosphonylmethoxy ethyloxy)adenine, 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine, (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, 9-(3-hydroxy-2-phosphonylmethoxypropyl)guanine, and (S)-9-(3-fluoro-2-phosphonyl methoxypropyl)adenine; V is selected from a group consisting of phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl, 3-furanyl, 2-thienyl, and 3-thienyl, all optionally substituted with 1-3 substituents selected from a group consisting of F, Cl, Br, C1-C3 alkyl, CF.sub.3 and OR.sup.6; R.sup.6 is selected from the group consisting of C1-C3 alkyl, and CF.sub.3; and pharmaceutically acceptable salts thereof.

  Recently Added Patents
Network system of projector
Method of estimating a degree of contamination of a front screen of an optical detection apparatus and optical detection apparatus
Compensation of thermally induced refractive index distortions in an optical gain medium or other optical element
Apparatus and method for product and signaling device matching
Sliding stacks
Pneumatic tire with tread having shoulder blocks and crown blocks
Composite crystal colloidal array with photochromic member
  Randomly Featured Patents
Process and device for watching the weft on weaving looms
Subjective optometric apparatus
Method and system for interference cancellation
Honeysweet pear tree
Endothelin antagonist and/or endothelin synthase inhibitor in combination with a progestin, an estrogen, a cyclooxygenase inhibitor, or a nitric acid donor or substrate
Electric double-layer capacitor
Parallel compression and decompression system and method having multiple parallel compression and decompression engines
Tempering glass sheets
Motor vehicle maintenance interval monitor
Code detection by using genetic algorithms