Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs










Image Number 16 for United States Patent #7169551.

The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient infected by the virus; (b) co-transfecting into a first cell (i) the nucleic acid of step (a), and (ii) a viral expression vector which lacks a nucleic acid encoding an envelope protein, and which comprises an indicator nucleic acid which produces a detectable signal, such that the first cell produces viral particles comprising the envelope protein encoded by the nucleic acid obtained from the patient; (c) contacting the viral particles produced in step (b) with a second cell in the presence of the compound, wherein the second cell expresses a cell surface receptor to which the virus binds; (d) measuring the amount of signal produced by the second cell in order to determine the infectivity of the viral particles; and (e) comparing the amount of signal measured in step (d) with the amount of signal produced in the absence of the compound, wherein a reduced amount of signal measured in the presence of the compound indicates that the compound inhibits entry of the virus into the second cell.








 
 
  Recently Added Patents
Antenna for an automobile
Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents
Automated incorporation of expert feedback into a monitoring system
Weighted determination in configuration management systems
Brushless motor drive apparatus and drive method
Method and apparatus for coordinating hopping of resources in wireless communication systems
Timing and cell specific system information handling for handover in evolved UTRA
  Randomly Featured Patents
Therapeutics for thrombocytopenia
Radio transceiver capable of avoiding intermodulation distortion
Area lighting system with solar module
Integrated circuit package for coupling to a printed circuit board
Method for conditioning organic pigments
Intelligent electrical switching device
Air conditioning system comprising an electronic control device
Impression cylinder with domelike surface portions of uniform height
Sheet forming machine
Electro-mechanical safety and arming device