Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs










Image Number 16 for United States Patent #7169551.

The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient infected by the virus; (b) co-transfecting into a first cell (i) the nucleic acid of step (a), and (ii) a viral expression vector which lacks a nucleic acid encoding an envelope protein, and which comprises an indicator nucleic acid which produces a detectable signal, such that the first cell produces viral particles comprising the envelope protein encoded by the nucleic acid obtained from the patient; (c) contacting the viral particles produced in step (b) with a second cell in the presence of the compound, wherein the second cell expresses a cell surface receptor to which the virus binds; (d) measuring the amount of signal produced by the second cell in order to determine the infectivity of the viral particles; and (e) comparing the amount of signal measured in step (d) with the amount of signal produced in the absence of the compound, wherein a reduced amount of signal measured in the presence of the compound indicates that the compound inhibits entry of the virus into the second cell.








 
 
  Recently Added Patents
Thermochromic microparticles, dispersions thereof, and manufacturing method thereof, as well as light-modulating coatings, light-modulating films and light-modulating inks
Permitting access of slave device from master device based on process ID's
Boundary acoustic wave device
For a given cell in a spreadsheet, evaluating an unlimited number of conditional formatting rules and applying multiple corresponding formats to the cell
Systems and methods for advertising on content-screened web pages
Magnetic resonance imaging apparatus
LED-array package
  Randomly Featured Patents
Process for solid phase platelet antibody assay
Dresser
Power component bearing interconnections
Toaster with safety shut-off
Front portion of a motor vehicle
Motorcycle flywheel assembly
Poultry leg and thigh processor
Oxamide IMPDH inhibitors
Lid opener
Process for gasification of coal to maximize coal utilization and minimize quantity and ecological impact of waste products