Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Methods of evaluating viral entry inhibitors using patient derived envelope protein constructs










Image Number 16 for United States Patent #7169551.

The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient infected by the virus; (b) co-transfecting into a first cell (i) the nucleic acid of step (a), and (ii) a viral expression vector which lacks a nucleic acid encoding an envelope protein, and which comprises an indicator nucleic acid which produces a detectable signal, such that the first cell produces viral particles comprising the envelope protein encoded by the nucleic acid obtained from the patient; (c) contacting the viral particles produced in step (b) with a second cell in the presence of the compound, wherein the second cell expresses a cell surface receptor to which the virus binds; (d) measuring the amount of signal produced by the second cell in order to determine the infectivity of the viral particles; and (e) comparing the amount of signal measured in step (d) with the amount of signal produced in the absence of the compound, wherein a reduced amount of signal measured in the presence of the compound indicates that the compound inhibits entry of the virus into the second cell.








 
 
  Recently Added Patents
Towel clip
Proximity search methods using tiles to represent geographical zones
Session transfer method, application server, and communications system
Guitar strap attachment means
Antenna array system
Indicating transfer in an IMS network
System and method for routing streaming data requests
  Randomly Featured Patents
Aqueous hair cleansing agent
Changing a design rule for forming LSI pattern based on evaluating effectiveness of optical proximity corrected patterns
Chair base
Pressure-sensitive poly(n-vinyl lactam) adhesive composition and skin covering articles using same
Networked gaming system including a live floor view module
Process for removing nitrogen oxides and sulfur dioxide from effluent gases
Method of manufacturing a surface layer modified, molded article of aromatic polymer and the article so produced
Apparatus and method for inspecting pattern
Blends of linear low density ethylene copolymers
Apparatus for position encoding