Resources Contact Us Home
Modified factor VIII

Image Number 7 for United States Patent #7012132.

Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients who have developed such antibodies after being treated with factor VIII. Modified factor VIII is disclosed in which the amino acid sequence is changed by a substitution at one or more of the specific loci. The modified factor VIII is not inhibited by inhibitory antibodies against the A2 or C2 domain epitopes. The modified factor VIII is useful for hemophiliacs, either to avoid or prevent the action of inhibitory antibodies.

  Recently Added Patents
Lubricant coating device and image forming apparatus
Organic light emitting device connection methods
Display screen with graphical user interface
Far field telemetry operations between an external device and an implantable medical device during recharge of the implantable medical device via a proximity coupling
Method of monitoring and configuring
Mobile application for calendar sharing and scheduling
Systems and methods for reducing narrow bandwidth interference contained in broad bandwidth signals
  Randomly Featured Patents
Upright-pin-joined resin substrate, method of producing the substrate, pins, and method of producing the pins
Bimodal block copolymer containing tapered block, process for manufacturing method and its usage
Visual lecture aid
Throttle valve control system for internal combustion engine
Optically active salts of a substituted thiazolidine-4-carboxylate and 3-cyano-hydroxypropyl trimethyl-ammonium, their production and uses
Free-flowing plural extrudates of polar ethylene interpolymers
Enhanced cross-talk suppression in magnetoresistive sensors
Droplet deposition apparatus
Biocompatible polyacrylate compositions for medical applications
Operation method of furnace equipment for magnesium alloys