Resources Contact Us Home
Modified factor VIII

Image Number 7 for United States Patent #7012132.

Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients who have developed such antibodies after being treated with factor VIII. Modified factor VIII is disclosed in which the amino acid sequence is changed by a substitution at one or more of the specific loci. The modified factor VIII is not inhibited by inhibitory antibodies against the A2 or C2 domain epitopes. The modified factor VIII is useful for hemophiliacs, either to avoid or prevent the action of inhibitory antibodies.

  Recently Added Patents
Computer server capable of supporting CPU virtualization
Preparation process of transition metal boride and uses thereof
Non-phosphorus-based gellant for hydrocarbon fluids
Plasma panel based radiation detector
Device for transmitting data between a serial data bus and working modules such as actuator modules and/or I/O modules
Security arrangements for extended USB protocol stack of a USB host system
Lubricant supplying device, process cartridge, and image forming apparatus
  Randomly Featured Patents
Method and apparatus for cutting continuous fibrous material
Operating system providing a mutual exclusion mechanism
Abuse-type drug test papers and methods of making and using same
Magazine disk player having an improved magazine detecting feature
Method and circuitry for calibrating a micromachined sensor
Camera which incorporates a lens unit that can program an optical property comprising a selection unit
Apparatus including two housings and a piezoelectric transducer
Flow controller
Soil retainer block
Gas turbine combustor