Resources Contact Us Home
Everninomicin biosynthetic genes

Image Number 107 for United States Patent #6861513.

This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin biosynthetic genes, which provide the machinery for producing everninomicin, are provided. Thus, this invention provides the nucleic acid sequences needed to synthesize novel everninomicin-related compounds based on everninomicin, arising from modifications of the DNA sequence designed to change glycosyl and modified orsellinic acid groups contained in everninomicin. A. Micromonospora site-specific integrase gene is also provided, which can be incorporated in a vector for integration into any actinomycete, and, particularly into Monospora. Thus, the invention further provides methods for introducing heterologous genes into an actinomycete chromosome using this particular vector.

  Recently Added Patents
Method and a channel estimating arrangement for performing channel estimation
Process for producing dipeptides or dipeptide derivatives
Enhanced claims damage estimation using aggregate display
Light-emitting device
Self-assembling surface coating
Tungsten barrier and seed for copper filled TSV
Modular sport center
  Randomly Featured Patents
Connector for structural systems
Hydrogen thermal electrochemical converter
Apparatus for transmitting cells between ATM layer and physical layer and method therefor
Image processing apparatus
Remote control caddy
Vacuum debulk and radiation cure method
Troposcatter system antenna alignment
Nanofiber packed beds having enhanced fluid flow characteristics
Press apparatus for detecting a force occurring between two oppositely movable machine parts
Optical connector with a surface mounted shield