Resources Contact Us Home
Everninomicin biosynthetic genes

Image Number 107 for United States Patent #6861513.

This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin biosynthetic genes, which provide the machinery for producing everninomicin, are provided. Thus, this invention provides the nucleic acid sequences needed to synthesize novel everninomicin-related compounds based on everninomicin, arising from modifications of the DNA sequence designed to change glycosyl and modified orsellinic acid groups contained in everninomicin. A. Micromonospora site-specific integrase gene is also provided, which can be incorporated in a vector for integration into any actinomycete, and, particularly into Monospora. Thus, the invention further provides methods for introducing heterologous genes into an actinomycete chromosome using this particular vector.

  Recently Added Patents
Structure of circuit board and method for fabricating the same
Spin transition material
Method and system of extending battery life of a wireless microphone unit
Using location based services for determining a calling window
Lighting device with device for regulating the illumination according to the luminance of the illumination field and corresponding use
Stroboscopic image modulation to reduce the visual blur of an object being viewed by an observer experiencing vibration
Electric connection box
  Randomly Featured Patents
Aqueous carbonaceous slurries
Optical head, recording and/or reproducing method and apparatus and method for detecting thickness
Wood burning automatic swimming pool heater
Outer mirror for an automobile
Power unit supporting structure
Hydrostatic power steering system
Crown line and window configuration for a jet airplane
Correlation method for monitoring power amplifier
Rotary actuator
Cord organizer