Resources Contact Us Home
Everninomicin biosynthetic genes

Image Number 107 for United States Patent #6861513.

This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin biosynthetic genes, which provide the machinery for producing everninomicin, are provided. Thus, this invention provides the nucleic acid sequences needed to synthesize novel everninomicin-related compounds based on everninomicin, arising from modifications of the DNA sequence designed to change glycosyl and modified orsellinic acid groups contained in everninomicin. A. Micromonospora site-specific integrase gene is also provided, which can be incorporated in a vector for integration into any actinomycete, and, particularly into Monospora. Thus, the invention further provides methods for introducing heterologous genes into an actinomycete chromosome using this particular vector.

  Recently Added Patents
System and method of error reporting in a video distribution network
Nucleic acids for cloning and expressing multiprotein complexes
Methods for non-linear image blending, adjustment and display
Permanent magnet axial field zeeman slower
Moving structure and micro-mirror device using the same
Circuit device for preventing radiation emission in portable terminal with two cameras
  Randomly Featured Patents
Crash barriers for roads
Attachable ear covering for sport activities
Livestock feed tub
Wheel cover
Pet item storage unit
High pressure spray cleaning head
Alignment cam for non-circular retractable antenna
Power supply particularly for a meter-bus
Semiconductor integrated circuit and fabrication process thereof