Resources Contact Us Home
Method of using G-matrix Fourier transformation nuclear magnetic resonance (GFT NMR) spectroscopy for rapid chemical shift assignment and secondary structure determination of proteins

Image Number 18 for United States Patent #6831459.

The present invention presents a new approach to rapidly obtaining precise high-dimensional NMR spectral information, named "GFT NMR spectroscopy", which is based on the phase sensitive joint sampling of the indirect dimensions spanning a subspace of a conventional NMR experiment. The phase-sensitive joint sampling of several indirect dimensions of a high-dimensional NMR experiment leads to largely reduced minimum measurement times when compared to FT NMR. This allows one to avoid the "sampling limited" data collection regime. Concomitantly, the analysis of the resulting chemical shift multiplets, which are edited by the G-matrix transformation, yields increased precision for the measurement of the chemical shifts. Additionally, methods of conducting specific GFT NMR experiments as well as methods of conducting a combination of GFT NMR experiments for rapidly obtaining precise chemical shift assignment and determining the structure of proteins or other molecules are disclosed.

  Recently Added Patents
Method for producing cathode active material for a lithium secondary battery
Media processing method and device
Image forming apparatus, control method of image forming apparatus, and storage medium
Systems, devices, methods, and compositions including fluidized x-ray shielding compositions
Non-volatile memory array and device using erase markers
Fast port switching in an audiovisual receiver by use of port pre-authentication by a partial PHY decoder core
Customizing a range of acceptable tape dimensional stability write conditions
  Randomly Featured Patents
Method and system for handling context of data packet flows
Wheel improvement for roller skates
Azapeptide acids as cell adhesion inhibitors
Process for making a lightweight, cementitious, three dimensional structure
Card holder for container
Method and apparatus for disposal of cuttings
Zoom lens and image pickup apparatus including the same
Rooster weathervane
Metadata broker
Apparatus and methods for measuring resistance of conductive layers