Resources Contact Us Home
Method of using G-matrix Fourier transformation nuclear magnetic resonance (GFT NMR) spectroscopy for rapid chemical shift assignment and secondary structure determination of proteins

Image Number 18 for United States Patent #6831459.

The present invention presents a new approach to rapidly obtaining precise high-dimensional NMR spectral information, named "GFT NMR spectroscopy", which is based on the phase sensitive joint sampling of the indirect dimensions spanning a subspace of a conventional NMR experiment. The phase-sensitive joint sampling of several indirect dimensions of a high-dimensional NMR experiment leads to largely reduced minimum measurement times when compared to FT NMR. This allows one to avoid the "sampling limited" data collection regime. Concomitantly, the analysis of the resulting chemical shift multiplets, which are edited by the G-matrix transformation, yields increased precision for the measurement of the chemical shifts. Additionally, methods of conducting specific GFT NMR experiments as well as methods of conducting a combination of GFT NMR experiments for rapidly obtaining precise chemical shift assignment and determining the structure of proteins or other molecules are disclosed.

  Recently Added Patents
RFID reader revocation checking using low power attached displays
Method for manufacturing photoelectric conversion device
Radio communication system, base station device and mobile station device utilizing an intermittent reception
Remote device pairing setup
Bullet lens design for the dasal seeker
Metal-doped oxide, method of preparing the same, and solid oxide electrolyte using the metal-doped oxide
  Randomly Featured Patents
Locking cylinder
Carbanilide antibacterial composition
Image pickup apparatus including interruption means for causing recordation of an electrical image signal in response to operation of a second trigger before completion of a predetermined step
Keyboard-type tone plate percussion instrument
Camera for shooting movie and still picture
Medical ultrasound transducer
Rotary driving device and image forming apparatus
Method of and system for confirming program materials to be broadcasted and then broadcasting the program materials, and recording medium having recorded therein a procedure for implementing t
Method and apparatus for generating and employing a run-time generated stub to reference an object in object oriented systems
Tubular membrane vent