Resources Contact Us Home
Method of using G-matrix Fourier transformation nuclear magnetic resonance (GFT NMR) spectroscopy for rapid chemical shift assignment and secondary structure determination of proteins

Image Number 14 for United States Patent #6831459.

The present invention presents a new approach to rapidly obtaining precise high-dimensional NMR spectral information, named "GFT NMR spectroscopy", which is based on the phase sensitive joint sampling of the indirect dimensions spanning a subspace of a conventional NMR experiment. The phase-sensitive joint sampling of several indirect dimensions of a high-dimensional NMR experiment leads to largely reduced minimum measurement times when compared to FT NMR. This allows one to avoid the "sampling limited" data collection regime. Concomitantly, the analysis of the resulting chemical shift multiplets, which are edited by the G-matrix transformation, yields increased precision for the measurement of the chemical shifts. Additionally, methods of conducting specific GFT NMR experiments as well as methods of conducting a combination of GFT NMR experiments for rapidly obtaining precise chemical shift assignment and determining the structure of proteins or other molecules are disclosed.

  Recently Added Patents
Calibration device and related method for phase difference between data and clock
Using sets of OTDR receive fibers with different lengths of marker events to verify optical fiber connectivity
Resonant conversion system with over-current protection processes
Fire detector
Device for transmitting data between a serial data bus and working modules such as actuator modules and/or I/O modules
Terminal box assembly
Reflective mask blank and method of manufacturing a reflective mask
  Randomly Featured Patents
Video game machine
Participation systems and methods
Use of venting slots to improve hermetic seal for semiconductor dice housed in ceramic packages
Press-curable fluoropolymer compositions and process
Two-piece base pad igniter bag
Method and apparatus for multistage document format transformation in a data processing system
Lithographic apparatus and device manufacturing method
Layer density determination using surface and deviated borehole gravity values
Mechanical arm system for opening a door
Water purification