Resources Contact Us Home
Method of using G-matrix Fourier transformation nuclear magnetic resonance (GFT NMR) spectroscopy for rapid chemical shift assignment and secondary structure determination of proteins

Image Number 11 for United States Patent #6831459.

The present invention presents a new approach to rapidly obtaining precise high-dimensional NMR spectral information, named "GFT NMR spectroscopy", which is based on the phase sensitive joint sampling of the indirect dimensions spanning a subspace of a conventional NMR experiment. The phase-sensitive joint sampling of several indirect dimensions of a high-dimensional NMR experiment leads to largely reduced minimum measurement times when compared to FT NMR. This allows one to avoid the "sampling limited" data collection regime. Concomitantly, the analysis of the resulting chemical shift multiplets, which are edited by the G-matrix transformation, yields increased precision for the measurement of the chemical shifts. Additionally, methods of conducting specific GFT NMR experiments as well as methods of conducting a combination of GFT NMR experiments for rapidly obtaining precise chemical shift assignment and determining the structure of proteins or other molecules are disclosed.

  Recently Added Patents
Method for releasing a locking in mobile terminal and mobile terminal using the same
Estimating travel time
Communication device
Trash receptacle
Sequential control device for a striking mechanism
Information processing apparatus and display control method
Method and apparatus for distributing promotional materials
  Randomly Featured Patents
Easy opening and secure closing closure
Start-up circuit and start-up method
Structured forming fabric and method
Knee brace and method for securing the same
Fast voltage regulators for charge pumps
Temperature monitoring and temperature differential control device
Method for manufacturing highly-concentrated polyglutamic acid with additional supply of saccharides
Flow meter including a balance member
Processor with power control via instruction issuance
Playing structure and modules therefor