Resources Contact Us Home
Probe composition comprising a binding polymer and polymer chain and methods of use

Image Number 13 for United States Patent #6756204.

Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In the method, a mixture of sequence-specific probes are reacted with the target polynucleotide under hybridization conditions, and the hybridized probes are treated to selectively modify those probes which are bound to the target polynucleotide in a base-specific manner. The resulting labeled probes include a polymer chain which imparts to each different-sequence probe, a distinctive ratio of charge/translational frictional drag, and a detectable label. The labeled probes are fractionated by electrophoresis in a non-sieving matrix, and the presence of one or more selected sequences in the target polynucleotide are detected according to the observed electrophoretic migration rates of the labeled probes in a non-sieving medium.

  Recently Added Patents
Interaction analysis and prioritization of mobile content
Cationic polymers for antimicrobial applications and delivery of bioactive materials
Semiconductor overlapped PN structure and manufacturing method thereof
Lipoprotein analysis by differential charged-particle mobility
Moving structure and micro-mirror device using the same
Sealed, waterproof digital electronic camera system and method of fabricating same
Secure access to customer log data in a multi-tenant environment
  Randomly Featured Patents
Photo/picture frame
Light emitting diode lamp
Power supply circuit
Predicting movement of a mobile node from a current access location to next access locations
Gas refining system
Finger ring or similar article
Modular gas panel closet for a semiconductor wafer processing platform
Integrating receiver with precharge circuitry
Crowd control barrier
Multiple layer pipe