Resources Contact Us Home
Probe composition comprising a binding polymer and polymer chain and methods of use

Image Number 13 for United States Patent #6756204.

Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In the method, a mixture of sequence-specific probes are reacted with the target polynucleotide under hybridization conditions, and the hybridized probes are treated to selectively modify those probes which are bound to the target polynucleotide in a base-specific manner. The resulting labeled probes include a polymer chain which imparts to each different-sequence probe, a distinctive ratio of charge/translational frictional drag, and a detectable label. The labeled probes are fractionated by electrophoresis in a non-sieving matrix, and the presence of one or more selected sequences in the target polynucleotide are detected according to the observed electrophoretic migration rates of the labeled probes in a non-sieving medium.

  Recently Added Patents
Encrypting method, recording medium of encrypting program, decrypting method, and recording medium of decrypting program
Wind power generator
Multipurpose sequential droplet applicator
Polypropylene with bio-based and synthetic fillers for light weight material applications
Method and system for transmitting a 1080P60 video in 1080i format to a legacy 1080i capable video receiver without resolution loss
Semiconductor image sensor module, method for manufacturing the same as well as camera and method for manufacturing the same
Sensor harness clamp for continuous casting sensors
  Randomly Featured Patents
Printing method and apparatus
Pressure and temperature control for fuel delivery systems
Method for vertical continuous casting of metals using electromagnetic fields and casting installation therefor
Power line to drive a vehicle
Methods of and apparatus for measuring time of arrival of remote Loran-C and related signals and effective time of transmission of local signals at transmitter sites
Rotational indexing nozzle arrangement
Mobile sweeper
Tantalum compound, method for producing same, tantalum-containing thin film and method for forming same
Catalytic combustor for a gas turbine
Motorcycle tire