Resources Contact Us Home
Probe composition comprising a binding polymer and polymer chain and methods of use

Image Number 13 for United States Patent #6756204.

Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In the method, a mixture of sequence-specific probes are reacted with the target polynucleotide under hybridization conditions, and the hybridized probes are treated to selectively modify those probes which are bound to the target polynucleotide in a base-specific manner. The resulting labeled probes include a polymer chain which imparts to each different-sequence probe, a distinctive ratio of charge/translational frictional drag, and a detectable label. The labeled probes are fractionated by electrophoresis in a non-sieving matrix, and the presence of one or more selected sequences in the target polynucleotide are detected according to the observed electrophoretic migration rates of the labeled probes in a non-sieving medium.

  Recently Added Patents
Flavonoid dimers and methods of making and using such
Workflow-enabled client
Method and apparatus for monitoring wireless communication in hearing assistance systems
Light fitting
Method and composition for attracting arthropods by volatizing an acid
Shoe bag
Adhesive structure of optical device, adhesion method, and optical pickup device
  Randomly Featured Patents
Stable emulsion blends and methods for their use
Fibrinogen-free plasminogen-plasmin-free plasma and method of preparing and using same
Manifolded fuel vapor
Scroll apparatus
Tranformation of cells associated with fluid spaces
Hanging pot with detachable tray
High-speed sense amplifier
Portable container for valuable articles
Process for preparing cephem derivative
Winding system for air-cooled transformers