Resources Contact Us Home
Probe composition comprising a binding polymer and polymer chain and methods of use

Image Number 13 for United States Patent #6756204.

Method and composition for detecting one or more selected polynucleotide regions in a target polynucleotide. In the method, a mixture of sequence-specific probes are reacted with the target polynucleotide under hybridization conditions, and the hybridized probes are treated to selectively modify those probes which are bound to the target polynucleotide in a base-specific manner. The resulting labeled probes include a polymer chain which imparts to each different-sequence probe, a distinctive ratio of charge/translational frictional drag, and a detectable label. The labeled probes are fractionated by electrophoresis in a non-sieving matrix, and the presence of one or more selected sequences in the target polynucleotide are detected according to the observed electrophoretic migration rates of the labeled probes in a non-sieving medium.

  Recently Added Patents
Organic light emitting diode light source device
Radiation protective garment with forced ventilation and method
Detection system and method for mobile device application
Neuronal differentiation-inducing peptide and use thereof
Apparatus and sensor for adjusting vertical sensor-alignment
Image reproduction system and image reproduction processing program
Method and apparatus for controlling the use of data stored on a media sample
  Randomly Featured Patents
Transconductance power amplifier
Screening apparatus for efficiently separating coarse material from finer material
Amphibious aircraft
Recreational vehicle slide-out awning with intermediate support
Nuclear fuel pellets and method of manufacturing the same
Oxygen/carbon blowing lance assembly
Displation type electrical connector
Roll paper handling apparatus
Communication device and communication device control method