Resources Contact Us Home
Methods of identifying compounds that bind to target species under isothermal denaturing conditions

Image Number 4 for United States Patent #6713260.

The present invention provides a method for identifying a test compound that binds to a target species. The method includes: incubating at least one test mixture under isothermal denaturing conditions, each test mixture comprising at least one test compound, and at least one target species, wherein the isothermal denaturing conditions are effective to cause at least a portion of the target species to denature to a measurable extent; detecting a denaturation signal of each target species in the presence of the at least one test compound by a change in the diffusion properties of the target molecule using fluorescence correlation spectroscopy; and comparing the denaturation signal of each target species in the presence of at least one test compound with a denaturation signal of the same target species in the absence of the at least one test compound under the same isothermal denaturing conditions.

  Recently Added Patents
Methods and systems for creating a tail risk hedge index and trading derivative products based thereon
Switched capacitor hold-up scheme for constant boost output voltage
Formwork release composition and use thereof
Methods of producing the membranes and the uses of membranes as battery separator films
Electric rotating machine for vehicle
Method and system for automatic 3-D image creation
Methods and systems for automated backups and recovery on multi-os platforms using controller-based snapshots
  Randomly Featured Patents
Internally lighted decorative display
Methods and apparatus for performing emergency extrications
Centrally managed modular infusion pump system
Nitride semiconductor light emitting diode
Electrostatic discharge protection oscillation circuit in LSI
Trench junction field-effect transistor
Connector for printed circuit boards
Lyophilized human hemoglobin standard for colorimetric determination of total hemoglobin
Line guide for fishing rod