Resources Contact Us Home
Methods of identifying compounds that bind to target species under isothermal denaturing conditions

Image Number 4 for United States Patent #6713260.

The present invention provides a method for identifying a test compound that binds to a target species. The method includes: incubating at least one test mixture under isothermal denaturing conditions, each test mixture comprising at least one test compound, and at least one target species, wherein the isothermal denaturing conditions are effective to cause at least a portion of the target species to denature to a measurable extent; detecting a denaturation signal of each target species in the presence of the at least one test compound by a change in the diffusion properties of the target molecule using fluorescence correlation spectroscopy; and comparing the denaturation signal of each target species in the presence of at least one test compound with a denaturation signal of the same target species in the absence of the at least one test compound under the same isothermal denaturing conditions.

  Recently Added Patents
Method of forming wafer level mold using glass fiber and wafer structure formed by the same
Utility knife
Use of endogenous promoters in genetic engineering of Nannochloropsis gaditana
Method and apparatus for monitoring wireless communication in hearing assistance systems
Simulating non power of two texture behavior
Support core for cold shrink tube
  Randomly Featured Patents
Misalignment correction for embedded microelectronic die applications
Multi-resolution driver device
Detachable visual augmentation device (VAD) mounting bracket for firearms and optical devices
Method of document layout process and system therefor
Pharmacological inducement of the fed mode for enhanced drug administration to the stomach
Ball chair with a retaining device
Surveillant concurrent engineering process tool for environment rendering (SCEPTER) for resin flow monitoring in composites
Visual message waiting indication in a telephone voice message system
Irrigation valve for a cultivation table and related irrigation system
Document holder