Resources Contact Us Home
Methods of identifying compounds that bind to target species under isothermal denaturing conditions

Image Number 4 for United States Patent #6713260.

The present invention provides a method for identifying a test compound that binds to a target species. The method includes: incubating at least one test mixture under isothermal denaturing conditions, each test mixture comprising at least one test compound, and at least one target species, wherein the isothermal denaturing conditions are effective to cause at least a portion of the target species to denature to a measurable extent; detecting a denaturation signal of each target species in the presence of the at least one test compound by a change in the diffusion properties of the target molecule using fluorescence correlation spectroscopy; and comparing the denaturation signal of each target species in the presence of at least one test compound with a denaturation signal of the same target species in the absence of the at least one test compound under the same isothermal denaturing conditions.

  Recently Added Patents
Method and apparatuses for solving weighted planar graphs
Servomotor control circuit
Metal-doped oxide, method of preparing the same, and solid oxide electrolyte using the metal-doped oxide
Process for producing dipeptides or dipeptide derivatives
Light powered hearing aid
Semiconductor memory apparatus
Cucumber plants with a compact growing habit
  Randomly Featured Patents
Vehicle position calculation apparatus and method
Device cradle
Preparing membrane receptors from extracellular baciloviruses
Pressure gage with magnetically coupled diaphragm
Transmitter and transmitting method of tire air pressure monitoring apparatus
Method and apparatus for supporting a computer chassis
Method of making microwave heating material
Projection objective, projection exposure apparatus and reflective reticle for microlithography
Shoe structure with midsole channel between metatarsal and heel bulges
Foot lift