Resources Contact Us Home
Methods of identifying compounds that bind to target species under isothermal denaturing conditions

Image Number 4 for United States Patent #6713260.

The present invention provides a method for identifying a test compound that binds to a target species. The method includes: incubating at least one test mixture under isothermal denaturing conditions, each test mixture comprising at least one test compound, and at least one target species, wherein the isothermal denaturing conditions are effective to cause at least a portion of the target species to denature to a measurable extent; detecting a denaturation signal of each target species in the presence of the at least one test compound by a change in the diffusion properties of the target molecule using fluorescence correlation spectroscopy; and comparing the denaturation signal of each target species in the presence of at least one test compound with a denaturation signal of the same target species in the absence of the at least one test compound under the same isothermal denaturing conditions.

  Recently Added Patents
Image pickup device with a plurality of pixels and an AD conversion circuit
Solar power system with communication network utilizing magnetic fields
Managing a packet service call within mobile communications user equipment
Information retrieval system, information retrieval method, and information retrieval program
Video conference
Power supply device
Power consumption management in a MIMO transceiver and method for use therewith
  Randomly Featured Patents
Refuse collection apparatus
Soldering apparatus
Preemptive packet flow controller
Lighting control
Angular acceleration sensor
Formed core catheter guide wire assembly
Method of evaluating characteristics of a light beam apparatus for evaluating the characteristics and apparatus for adjusting a write unit by employing the evaluation method
Rotary separator with a porous shroud
Computer-controlled exhaust gas recirculation system for internal combustion engine
Solid electrolytic capacitor