Resources Contact Us Home
Microdose therapy

Image Number 2 for United States Patent #6610652.

Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (1/2 to 1/20) of those known to induce vasodilation in "normal" circulations. The low doses of these agents effectively alleviate vascular conditions associated with a reduction in NO production or an attenuation of NO effect, by restoring balance in vascular tone while exerting almost no systemic effect in normal vasculature.

  Recently Added Patents
Apparatus and method to reduce noise in magnetic resonance imaging systems
Avalanche photo diode and method of manufacturing the same
Optical scanner and image-forming device
Catalyst compositions for hydroformylation reaction and hydroformylation process using the same
Method of forming a power supply controller and structure therefor
Method and system for providing complete internet anywhere with partial server processing
Retrievable outgoing audio messaging
  Randomly Featured Patents
Family of map2 protein kinases
Case structure
Process for winding wire upon a reel
Nesting curb
PSK Demodulator with automatic compensation of delay induced phase shifts
Variable size above-ground swimming pool
Extension member anchor
Real-time single entry multiple carrier interface (SEMCI)
Toners comprising modified pigments and processes for preparing the same
Fruit shaker