Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Microdose therapy










Image Number 2 for United States Patent #6610652.

Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (1/2 to 1/20) of those known to induce vasodilation in "normal" circulations. The low doses of these agents effectively alleviate vascular conditions associated with a reduction in NO production or an attenuation of NO effect, by restoring balance in vascular tone while exerting almost no systemic effect in normal vasculature.








 
 
  Recently Added Patents
Cap for storing materials separate from a body of liquid and facilitating subsequent mixing of the materials and the liquid
Closure cap comprising a seal gasket
Collapsible, transportable cart for building materials
Wrench
System and method for handling data transfers
Structure of high-K metal gate semiconductor transistor
Fast, language-independent method for user authentication by voice
  Randomly Featured Patents
Tool-holding fixture for tools supplied with coolant or lubricant and associated reservoir for coolant or lubricant
Removable heel pad for foot-receiving device
Temperature controlling method of electron bombardment heating apparatus
Homogenizer device with improved valve for preparing whipped cream
Ram moving method for hydraulic machine, ram movement controller, method for preventing trapping of axial plunger pump used for the machine, and the pump
Method for dense pixel fabrication and product thereof
Electric control apparatus for dishwashing machine
Soybean cultivar 0491722
Method for processing an end of a shielded cable
Process for producing yeast extract