Resources Contact Us Home
Microdose therapy

Image Number 2 for United States Patent #6610652.

Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (1/2 to 1/20) of those known to induce vasodilation in "normal" circulations. The low doses of these agents effectively alleviate vascular conditions associated with a reduction in NO production or an attenuation of NO effect, by restoring balance in vascular tone while exerting almost no systemic effect in normal vasculature.

  Recently Added Patents
Sample analyzing device
Cooking oven with energy saving mode and method
Heterocyclic compounds as CCR2B antagonists
Schottky diode and method of manufacture
Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
Method and system of channel detecting and reporting, terminal, and management center
Materials for organic electroluminescent devices containing substituted 10-benzo[c]phenanthrenes
  Randomly Featured Patents
Critical current density in Nb.sub.3Sn superconducting wire
Automatic temperature control valve
Insulating-containing ring-shaped heat shields for czochralski pullers
Flame retardant styrene-based resin composition with high impact property
Toy vehicle
External counter pulsation treatment
Methods and materials for treating autoimmune and/or complement mediated diseases and conditions
Forage compaction apparatus with constant angle rotor
Casserole cozy
Picture display device provided with an electron gun, and electron gun for use in such a device