Resources Contact Us Home
Microdose therapy

Image Number 2 for United States Patent #6610652.

Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (1/2 to 1/20) of those known to induce vasodilation in "normal" circulations. The low doses of these agents effectively alleviate vascular conditions associated with a reduction in NO production or an attenuation of NO effect, by restoring balance in vascular tone while exerting almost no systemic effect in normal vasculature.

  Recently Added Patents
3D solid-state arrangement for solid state memory
Waterproof wound protector
Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
Interconnecting virtual domains
HYR1 as a target for active and passive immunization against Candida
Flood protection apparatus and container data center including the same
Multi-radio coexistence
  Randomly Featured Patents
Instrument support apparatus having non-horizontal tiers and vertical axis pivot capability
Method of oxidizing or bleaching a contaminant in a non-aqueous fluid
Semiconductor circuit and predischarge method of semiconductor circuit
Peroxyester preparation method
On-demand auto-tuner for a plant control system
Fatigue life enhancement of dovetail connector slots and noncircular openings
Surgical implant
Flexible hinged cleat
Hardware device and method for creation and management of toe-based socket information