Resources Contact Us Home
Microdose therapy

Image Number 2 for United States Patent #6610652.

Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (1/2 to 1/20) of those known to induce vasodilation in "normal" circulations. The low doses of these agents effectively alleviate vascular conditions associated with a reduction in NO production or an attenuation of NO effect, by restoring balance in vascular tone while exerting almost no systemic effect in normal vasculature.

  Recently Added Patents
Method of using N-thio compounds for oligonucleotide synthesis
Avalanche photo diode and method of manufacturing the same
Method and apparatus for storing email messages
Display screen with graphical user interface
Wine bottle
Method for manufacturing and reoxidizing a TiN/Ta.sub.2O.sub.5/TiN capacitor
Sequential control device for a striking mechanism
  Randomly Featured Patents
Drive clutch with multi-staged displacement rate and a method for controlling a drive clutch
Triazolo [4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation
Method of directly or indirectly applying a liquid or pasty medium to a continuous material web so that said medium on said web has a predetermined transverse and/or longitudinal profile
Method for making hollow workpieces
Method for preparing food product
Hybrid inertial and touch sensing input device
Optical disk drive apparatus having counter disable at seek start-up
Impact-resistant polyamide composition
Foldable igniter
Hydromorphone and hydrocodone compositions and methods for their synthesis