Resources Contact Us Home
Microdose therapy

Image Number 2 for United States Patent #6610652.

Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (1/2 to 1/20) of those known to induce vasodilation in "normal" circulations. The low doses of these agents effectively alleviate vascular conditions associated with a reduction in NO production or an attenuation of NO effect, by restoring balance in vascular tone while exerting almost no systemic effect in normal vasculature.

  Recently Added Patents
Flash memory apparatus and method for generating read voltage thereof
System and method of detecting and locating intermittent and other faults
Sample holder and method for treating sample material
Method of bonding metallic members, and metallic bonded body
Air-fuel ratio control apparatus for an internal combustion engine
DFPase enzymes from Aplysia californica
Nucleic acid-based tests for prenatal gender determination
  Randomly Featured Patents
Rotary puzzle
Contact image sensor hand-held scanner
Method and system for thin client based image and transaction management
Tub table
Guidance pattern allowing for access paths
Projection exposure method and apparatus capable of performing focus detection with high accuracy
Dual containment pipe system and a manhole system
Expandable and expanded plastic materials and methods for casting metal castings employing such expanded cellular plastic materials
Diaphragm valve
Al-Mg-Si Extrusion alloy