Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Microdose therapy










Image Number 2 for United States Patent #6610652.

Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (1/2 to 1/20) of those known to induce vasodilation in "normal" circulations. The low doses of these agents effectively alleviate vascular conditions associated with a reduction in NO production or an attenuation of NO effect, by restoring balance in vascular tone while exerting almost no systemic effect in normal vasculature.








 
 
  Recently Added Patents
High-performance AHCI interface
Hierarchical binding and lookup of addresses in inter-process communications systems
Polarization-coupled ferroelectric unipolar junction memory and energy storage device
Film-forming resins as a carrier for topical application of pharmacologically active agents
Portable electronic device holder and tether
Multi-bank queuing architecture for higher bandwidth on-chip memory buffer
Laser processing a multi-device panel
  Randomly Featured Patents
Base station for automated durability road (ADR) facility
Method and apparatus for surface processing using ice slurry
Direction and distance finder for locating distress signals
Appliance inlet
Faucet
Applet, archive file generation method, archive file generation program, and archive file generation device
Attachment device
Edge printing printer
Imaging system for creating an output signal including data double-sampled from an image sensor
Method of manufacturing an electric heating film of semiconductor