Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Microdose therapy










Image Number 2 for United States Patent #6610652.

Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provide NO, such as NO donors, agents which activate guanyl cyclase, such as YC-1, or agents which prolong the actions of endogenous NO or cyclic guanosine monophosphate (cGMP; a 2nd messenger molecule), such as phosphodiesterase (PDE) inhibitors. According to the invention, such agents are administered in minimal doses or microdoses by any route known in the art, so as to provide dosages which are about one half to about one twentieth (1/2 to 1/20) of those known to induce vasodilation in "normal" circulations. The low doses of these agents effectively alleviate vascular conditions associated with a reduction in NO production or an attenuation of NO effect, by restoring balance in vascular tone while exerting almost no systemic effect in normal vasculature.








 
 
  Recently Added Patents
Parallel power inverter motor drive system
Method, preprocessor, speech recognition system, and program product for extracting target speech by removing noise
Mono-body defibrillation probe
Management of memory array with magnetic random access memory (MRAM)
Digital photographing apparatus and control method for evaluating validity of an auto-focus operation
Optical interconnect in high-speed memory systems
Systems and methods for providing television signals using a network interface device
  Randomly Featured Patents
Disc access apparatus and disc access method
Poly LDD self-aligned channel transistors
System and method of providing audio content
Material based on silver and tin oxide for the production of electrical contacts; electrical contacts thus produced
Pneumatic tire
Board game with color tiles and letter tiles
Technique for modifying the capacity of gas-liquid separator
Method and device for multi photon excitation of a sample
Device and method for unlocking elevator doors
Constant combustion engine