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Immunomodulatory methods using Lewisx oligosacchardies










Image Number 19 for United States Patent #6540999.

Methods for modulating immune responses are provided. The methods involve contacting an immune cell with an agent that modulates interaction of a compound comprising a Lewis antigen with the immune cell such that production by the immune cell of at least one cytokine that regulates development of a T helper type 1 or T helper type 2 response is modulated. Stimulatory forms of the agent can comprise multivalent conjugates containing a Lewis antigen, such as a Lewis.sup.y, Lewis.sup.x or Lewis.sup.a -containing oligosaccharide, or a derivative thereof. Inhibitory forms of the agent can comprise non-crosslinked forms of a Lewis antigen, such as a Lewis.sup.y, Lewis.sup.x or Lewis.sup.a -containing oligosaccharide, or a derivative thereof. Stimulatory forms of the agent can be used in methods for stimulating a specific immune response to an antigen in vivo. Inhibitory forms of the agent can be used in methods for inhibiting allergic responses in vivo.








 
 
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