Resources Contact Us Home
Modulation of multicellular aggregates by pressure from growth in a matrix

Image Number 6 for United States Patent #6368858.

Cells in a matrix or in the matrix in a vessel are grown to form a multicellular aggregate. Pressure is exerted on the growing cells by the matrix or the matrix together with the vessel due to growing cellular mass displacing the matrix. A value representing pressure exerted on the cells is calculated and the pressure is modulated to control growth of the multicellular aggregate, or to produce a multicellular aggregate of a pre-selected size or a pre-selected size and shape. Matrices include agarose, alginate and collagen gels, and the pressure exerted on the cells can be non-isotropic. The cells may be tumor cells, or liver, pancreatic, brain, skin, bone or muscle cells, and cell growth can be in vitro or in vivo. When collagen forms the matrix, the matrix may contain glycosaminoglycan.

  Recently Added Patents
Shield for vacuum circuit breaker
Dot templates for object detection in images
Over the counter medicinal container with surface ornamentation
Process for producing a plasma protein-containing medicament with reduced concentration of citrate and metals
Electronic device with multi-orientation
Synchronization scheduling apparatus and method in real-time multi-core system
Information processing apparatus and method
  Randomly Featured Patents
Seal ring
Tensioning device
Rose plant--Keitoli variety
Apparatus for precision steeling/conditioning of knife edges
Semiconductor device, and method of manufacturing multilayer wiring board and semiconductor device
Vinylidene cyanide-vinyl benzoate derivative nonlinear optical polymers
Electrical connector with improved centering of mating terminal pins, for a fluorescent-lighting ballast
Aminoguanidines and alkoxyguanidines as protease inhibitors
Reflective data storage medium made by silver diffusion transfer in silver-halide emulsion incorporating nuclei
Switch having energy-efficient structural configuration