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Method for diagnosing an increased risk for thrombosis or a genetic defect causing thrombosis and kit for use with the same

Image Number 7 for United States Patent #5874256.

Method for screening for the presence of a genetic defect associated with thrombosis and/or poor anticoagulant response to activated protein C (APC). The method is directed at detecting one or more mutations at one or more of the cleavage and/or binding sites for APC of Factor V and/or Factor Va or at Factor VIII and/or Factor VIIIa at either nucleic acid or protein level or both.

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