Resources Contact Us Home
Method of producing hepatocycte growth factor/scatter factor and related cell lines

Image Number 15 for United States Patent #5871959.

A method of preventing tumor cell metastasis by inhibiting the binding of hepatocyte growth factor/scatter factor ("HGF/SF") with met proto-oncogene protein is described. A method of producing HGF/SF and a cell line for the production of HGF/SF are also described. The met proto-oncogene tyrosine kinase receptor (Met) and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), ordinarily constitute a paracrine signalling system in which cells of mesenchymal origin produce the ligand, which binds to the receptor that is predominantly expressed in cells of epithelial origin. The method of the present invention disrupts the Met-HGF/SF autocrine signaling that contributes to the tumorigenic process in tumors of mesenchymal origin, such as sarcomas.

  Recently Added Patents
System and method for order placement in an electronic trading environment
Process for preparing red cocoa ingredients, red chocolate, and food products
Humidity indicator and method for fabricating the same
Tropoelastin derivatives
System and method for interactive image-based modeling of curved surfaces using single-view and multi-view feature curves
Polishing composition
Plants and seeds of hybrid corn variety CH089600
  Randomly Featured Patents
Blanks for phase shift photomasks, and phase shift photomasks
Linear polyesteramides from aminophenolic esters
Rolling bearing
Inbred maize line PHBG4
Process for bleaching paper pulp using melamine as a viscosity stabilizer
Method of manufacturing a semiconductor device with a pn junction provided through epitaxy
Process of producing cross-linked urethane-group comprising foams of open-cell structure
Diagnostic system for the detection of skin cancer
Carbazole novolak resin
Printed circuit board for high-speed electrical connectors