Resources Contact Us Home
Method of producing hepatocycte growth factor/scatter factor and related cell lines

Image Number 15 for United States Patent #5871959.

A method of preventing tumor cell metastasis by inhibiting the binding of hepatocyte growth factor/scatter factor ("HGF/SF") with met proto-oncogene protein is described. A method of producing HGF/SF and a cell line for the production of HGF/SF are also described. The met proto-oncogene tyrosine kinase receptor (Met) and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), ordinarily constitute a paracrine signalling system in which cells of mesenchymal origin produce the ligand, which binds to the receptor that is predominantly expressed in cells of epithelial origin. The method of the present invention disrupts the Met-HGF/SF autocrine signaling that contributes to the tumorigenic process in tumors of mesenchymal origin, such as sarcomas.

  Recently Added Patents
Accelerator for a read-channel design and simulation tool
Reception system including a mechanism countering pulsed interference
System and method for access of user accounts on remote servers
Real ear measurement system using thin tube
Fuser member having composite outer layer
Securing information by hiding identity on a computing device
Surface acoustic wave resonator for down-hole applications
  Randomly Featured Patents
Reversible latching hinge
Collaborative speed determination in distributed systems
System and method for caching identification and location information in a computer network
Method for increasing the rate of absorption of polycaprolactone
Cordless electric drill
Additive and vehicle for inks, paints, coatings and adhesives
Controlled growth of a nanostructure on a substrate
Corn event 5307
Landing gear/stabilizer for small trailer
High efficiency heat transfer using asymmetric impinging jet