Resources Contact Us Home
Method of producing hepatocycte growth factor/scatter factor and related cell lines

Image Number 15 for United States Patent #5871959.

A method of preventing tumor cell metastasis by inhibiting the binding of hepatocyte growth factor/scatter factor ("HGF/SF") with met proto-oncogene protein is described. A method of producing HGF/SF and a cell line for the production of HGF/SF are also described. The met proto-oncogene tyrosine kinase receptor (Met) and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), ordinarily constitute a paracrine signalling system in which cells of mesenchymal origin produce the ligand, which binds to the receptor that is predominantly expressed in cells of epithelial origin. The method of the present invention disrupts the Met-HGF/SF autocrine signaling that contributes to the tumorigenic process in tumors of mesenchymal origin, such as sarcomas.

  Recently Added Patents
Method for producing organo-oligo silsesquioxanes
Detecting mirrors on the web
Relative pose estimation of non-overlapping cameras using the motion of subjects in the camera fields of view
Amide derivatives, process for preparation thereof and use thereof as insecticide
Computer product, information retrieval method, and information retrieval apparatus
Selection of hash lookup keys for efficient retrieval
ZnO green luminescent material and its preparation
  Randomly Featured Patents
Closed-loop cabin pressure control system test method with actual pressure feedback
Laminated polyester film
Exterior rearview mirror for vehicles, preferably for motor vehicles
Forklift truck
Image processing device and image correction device
Multiple stage process for cleaning process chambers
Card connector
Propulsion mechanism
Hydrogen odorants and odorant selection method