Resources Contact Us Home
Method of producing hepatocycte growth factor/scatter factor and related cell lines

Image Number 15 for United States Patent #5871959.

A method of preventing tumor cell metastasis by inhibiting the binding of hepatocyte growth factor/scatter factor ("HGF/SF") with met proto-oncogene protein is described. A method of producing HGF/SF and a cell line for the production of HGF/SF are also described. The met proto-oncogene tyrosine kinase receptor (Met) and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), ordinarily constitute a paracrine signalling system in which cells of mesenchymal origin produce the ligand, which binds to the receptor that is predominantly expressed in cells of epithelial origin. The method of the present invention disrupts the Met-HGF/SF autocrine signaling that contributes to the tumorigenic process in tumors of mesenchymal origin, such as sarcomas.

  Recently Added Patents
Method and system for network configuration for virtual machines
Simplified algorithm for abnormal situation prevention in load following applications including plugged line diagnostics in a dynamic process
Providing multiple decode options for a system-on-chip (SoC) fabric
Matching geometry generation and display of mammograms and tomosynthesis images
Aqueous flowable concentrate compositions of a microencapsulated dinitroaniline herbicide
Rewriting branch instructions using branch stubs
Methods for forming patterned structures
  Randomly Featured Patents
Shared sub-array marine seismic source system
Carton containing an article packaged therein
Disposable, one-piece filter unit
Tape closure for a can end
Vibration isolating apparatus
Spatial and temporal control of gene expression using a heat shock protein promoter in combination with local heat
Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment
Electrical connector having a U-shaped protective spring
Diagnosis and interpretation methods and apparatus for a personal nutrition program
DRAM circuitry