Resources Contact Us Home
Method of producing hepatocycte growth factor/scatter factor and related cell lines

Image Number 15 for United States Patent #5871959.

A method of preventing tumor cell metastasis by inhibiting the binding of hepatocyte growth factor/scatter factor ("HGF/SF") with met proto-oncogene protein is described. A method of producing HGF/SF and a cell line for the production of HGF/SF are also described. The met proto-oncogene tyrosine kinase receptor (Met) and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), ordinarily constitute a paracrine signalling system in which cells of mesenchymal origin produce the ligand, which binds to the receptor that is predominantly expressed in cells of epithelial origin. The method of the present invention disrupts the Met-HGF/SF autocrine signaling that contributes to the tumorigenic process in tumors of mesenchymal origin, such as sarcomas.

  Recently Added Patents
Dynamic pattern insertion layer
Systems and methods for analyzing and transforming an application from a source installation to a target installation
Sewing machine
MIMO transmitter and method for transmitting OFDM symbols
Battery pack system
Managing a cluster of computers
Secure computer provisioning
  Randomly Featured Patents
Method and apparatus for arbitrating access to a shared bus
Plant roots and bulb protection system
Automobile steering wheel lock
Hybrid power system for an electric vehicle
Vibration test fixture
Stereoscopic disk and viewer and method of making
Methods and devices for quantitative analysis of x-ray images
Connector for high currents
Apparatus for providing feedback to eliminate a DC component in the output of a static VAR generator
Device and method for controlling the temperature inside a refrigerating unit of a combined refrigerator-freezer