Resources Contact Us Home
Method of producing hepatocycte growth factor/scatter factor and related cell lines

Image Number 15 for United States Patent #5871959.

A method of preventing tumor cell metastasis by inhibiting the binding of hepatocyte growth factor/scatter factor ("HGF/SF") with met proto-oncogene protein is described. A method of producing HGF/SF and a cell line for the production of HGF/SF are also described. The met proto-oncogene tyrosine kinase receptor (Met) and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), ordinarily constitute a paracrine signalling system in which cells of mesenchymal origin produce the ligand, which binds to the receptor that is predominantly expressed in cells of epithelial origin. The method of the present invention disrupts the Met-HGF/SF autocrine signaling that contributes to the tumorigenic process in tumors of mesenchymal origin, such as sarcomas.

  Recently Added Patents
Method for evaluating performance characteristics of dental curing lights
Method for detecting directions of regularity in a two-dimensional image
Frequency offset estimation apparatus and method of OFDM system
Recovery of a hot-pluggable serial communication link
Alternate source programming
Tap initialization of equalizer based on estimated channel impulse response
Method for using extended security system, extended security system and devices
  Randomly Featured Patents
Aromatic polycarbonate resin composition
Nitrogen-containing condensation products based on unmodified or modified natural resins, process for the preparation thereof and the use thereof
Adjustable device for the treatment of female urinary incontinence
Franking machine
Adaptive voice and data bandwidth management system for multiple-line digital subscriber loop data communications
Training methods for aircraft simulator pilot
Twine actuated cutter in a rotary crop baler
Navigation system for providing real-time traffic information and traffic information processing method by the same
Portable truck tent
Seat belt cover