Resources Contact Us Home
Method of producing hepatocycte growth factor/scatter factor and related cell lines

Image Number 15 for United States Patent #5871959.

A method of preventing tumor cell metastasis by inhibiting the binding of hepatocyte growth factor/scatter factor ("HGF/SF") with met proto-oncogene protein is described. A method of producing HGF/SF and a cell line for the production of HGF/SF are also described. The met proto-oncogene tyrosine kinase receptor (Met) and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), ordinarily constitute a paracrine signalling system in which cells of mesenchymal origin produce the ligand, which binds to the receptor that is predominantly expressed in cells of epithelial origin. The method of the present invention disrupts the Met-HGF/SF autocrine signaling that contributes to the tumorigenic process in tumors of mesenchymal origin, such as sarcomas.

  Recently Added Patents
Lubricant composition and antioxident composition
Methods and apparatus for map detection with reduced complexity
Automated security analysis for federated relationship
Automatic fixup of network configuration on system image move
Peered proctoring
Lens system
Method for conformal plasma immersed ion implantation assisted by atomic layer deposition
  Randomly Featured Patents
System for conditional answering of requests
Dynamic wrist fixation apparatus for early joint motion in distal radius fractures
Dual mode piezoelectric filter, method of manufacturing the same, high frequency circuit component and communication device using the same
Solar array fabrication method and apparatus utilizing induction heating
Vehicle light
Heat dissipation from high power semiconductors in an electrical vehicle
Manual and automatic locking system for a multiparameter lighting fixture
Aluminum-zirconium compound-based treatment for herpes simplex virus lesions
Balloon expandable stent with low surface friction
Acid-reacted polymer-modified asphalt compositions and preparation thereof