Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists










Image Number 10 for United States Patent #5869049.

Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor on the surface of the T cell which inhibits interaction of the ligand on the antigen presenting cell with the receptor on the T cell. In a preferred embodiment, the cell which presents antigen to the T cell is a B cell and the receptor on the surface of the T cell which mediates contact-dependent helper effector function is gp39. Preferably, the antagonist is an anti-gp39 antibody or a soluble gp39 ligand (e.g., soluble CD40). The methods of the invention can be used to induce T cell tolerance to a soluble antigen or to an allogeneic cell. The methods of the invention can also be used to induce tolerance in cases of bone marrow transplantation and other organ transplants and to inhibit graft-versus-host disease.








 
 
  Recently Added Patents
Systems and methods for processing telephone calls
Dual gate electronic memory cell and device with dual gate electronic memory cells
Serving base station selection based on backhaul capability
Actuator, actuator structure and method of manufacturing actuator
Prevention and reduction of blood loss
High power fiber amplifier with stable output
Measurement of an analyte on the skin using a hue angle
  Randomly Featured Patents
Utility hand tool
Minimizing metal corrosion during post metal solvent clean
Workpiece transfer
Heat dissipation device having a fan mounted thereon
Purification process
Automatic battery charging system for a battery back-up DC power supply
Method and apparatus for sharing a universal serial bus device among multiple computers by switching
Microscope assembly having base mount for receiving dimmer circuit components
Nematicidal quinoxaline derivatives
Ice detection using radiometers