Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists










Image Number 10 for United States Patent #5869049.

Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor on the surface of the T cell which inhibits interaction of the ligand on the antigen presenting cell with the receptor on the T cell. In a preferred embodiment, the cell which presents antigen to the T cell is a B cell and the receptor on the surface of the T cell which mediates contact-dependent helper effector function is gp39. Preferably, the antagonist is an anti-gp39 antibody or a soluble gp39 ligand (e.g., soluble CD40). The methods of the invention can be used to induce T cell tolerance to a soluble antigen or to an allogeneic cell. The methods of the invention can also be used to induce tolerance in cases of bone marrow transplantation and other organ transplants and to inhibit graft-versus-host disease.








 
 
  Recently Added Patents
Direct file transfer between subscribers of a communications systems
Method, system and computer program product for verifying floating point divide operation results
Dynamic facsimile transcoding in a unified messaging platform
Pre and post-paid real time billing convergence system
Non-volatile memory array and device using erase markers
Encoding method and encoding device, decoding method and decoding device and transcoding method and transcoder for multi-object audio signals
Multichannel device utilizing a centralized out-of-band authentication system (COBAS)
  Randomly Featured Patents
Quad coil vibration cancelling metal detector
Amphotericin B/cholesterol sulfate composition and method
Fume hood cable system
Magnet, a method of adjustment of magnetic field and a magnetic resonance imaging apparatus
16836, A human phospholipase C family member, nucleic acids and uses thereof
Machine tool having drawbar mechanism
Aqueous compositions for visual inspection and cleaning of metallic surfaces
Dental articulation kit and method
Dumbbell system for muscles work
Method for operating an internal combustion engine