Resources Contact Us Home
Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists

Image Number 10 for United States Patent #5869049.

Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor on the surface of the T cell which inhibits interaction of the ligand on the antigen presenting cell with the receptor on the T cell. In a preferred embodiment, the cell which presents antigen to the T cell is a B cell and the receptor on the surface of the T cell which mediates contact-dependent helper effector function is gp39. Preferably, the antagonist is an anti-gp39 antibody or a soluble gp39 ligand (e.g., soluble CD40). The methods of the invention can be used to induce T cell tolerance to a soluble antigen or to an allogeneic cell. The methods of the invention can also be used to induce tolerance in cases of bone marrow transplantation and other organ transplants and to inhibit graft-versus-host disease.

  Recently Added Patents
Method for remotely measuring fluctuations in the optical index of refraction of a medium
Method and devices for handling access privileges
Apparatus and method for multiple pagings in broadband wireless communication system
Resistive random access memory cell and resistive random access memory module
Silicone hydrogel, lens for eye and contact lens
Anti-GITR antibodies
Compositions and methods using microspheres and non-ionic contrast agents
  Randomly Featured Patents
Compositions for improving flavor and safety of marinated meat products
Vehicle brake system with anti-skid apparatus
Illuminated exit bar
System and method for evaluating data sets over a communications network
Production of carbon monoxide-free hydrogen and helium from a high-purity source
Removable anchored lung volume reduction devices and methods
Coating solution for forming insulating film with excellent corrosion resistance property and film close adhesion property and film intensity without chrome and a method for making the insulat
Software testing using taint analysis and execution path alteration
Rinse-added fabric conditioning compositions containing fabric softening agents and cationic polyester soil release polymers and preferred cationic soil release polymers therefor
Duplexing antenna for portable radio transceiver