Resources Contact Us Home
Chromosome 13-linked breast cancer susceptibility gene

Image Number 4 for United States Patent #5837492.

The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast cancer predisposing gene (BRCA2), some mutant alleles of which cause susceptibility to cancer, in particular breast cancer. More specifically, the invention relates to germline mutations in the BRCA2 gene and their use in the diagnosis of predisposition to breast cancer. The present invention further relates to somatic mutations in the BRCA2 gene in human breast cancer and their use in the diagnosis and prognosis of human breast cancer. Additionally, the invention relates to somatic mutations in the BRCA2 gene in other human cancers and their use in the diagnosis and prognosis of human cancers. The invention also relates to the therapy of human cancers which have a mutation in the BRCA2 gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the BRCA2 gene for mutations, which are useful for diagnosing the predisposition to breast cancer.

  Recently Added Patents
Dielectric insulation medium
PMI feedback with codebook interpolation
Support for a parameterized query/view in complex event processing
Conductive polymer and a solid electrolytic capacitor using the same as a solid electrolyte
Laser marking of a card
Method and system for routing telephony communications together with modified calling party identifier information
Device having built-in digital data device and light for insertion into a lamp holder
  Randomly Featured Patents
Confocal microscope apparatus
Cable holding structure for wind turbine generator
Thermoplastic molding composition
Multiple shell multi faceted graphical user interface
Electro-magnetic linear drive
Articulating work platform support system, work platform system, and methods of use thereof
Communication terminal device and remote diagnostic method of the communication terminal device
Television tuner
Hand-held tool