Resources Contact Us Home
Treatment of vascular injury using vascular endothelial growth factor

Image Number 4 for United States Patent #5830879.

The present invention provides a method for inducing reendothelialization of the lining of an injured blood vessel comprising contacting the injured portion of the vessel with nucleic acid encoding an endothelial cell mitogen such as vascular endothelial growth factor (VEGF) operably linked to a promoter to result in expression of the mitogen when delivered to the cells at the site of vascular injury. The resulting reendothelialization of the injured blood vessel inhibits smooth muscle cell proliferation and consequently reduces restenosis. The methods of the present invention may be used to treat any blood vessel injury that results in denuding of the endothelial lining of the vessel wall, including, for example, those injuries resulting from balloon angioplasty and deployment of endovascular stents.

  Recently Added Patents
Gearbox housing
Classifying documents using multiple classifiers
Managing a spinlock indicative of exclusive access to a system resource
Nanoparticle entrapment of materials
Topology arrangement for achieving reliable communication in wireless automotive networks
Methods of making a diagnostic device by interweaving hydrophobic and hydrophilic fibers, and diagnostic device therefrom
Methods and apparatus for dynamic identification (ID) assignment in wireless networks
  Randomly Featured Patents
Programmable lock with integral change tooling
Advanced projection television screen
Preparation for improved dietary utilisation
Heating and extruding method for bulk preform
Low pressure measurement devices in high pressure environments
Image capturing and transmission device and image receiving and reconstruction device
Ultralow expansion brake rubber hose and its production method
Tube separator