Resources Contact Us Home
Treatment of vascular injury using vascular endothelial growth factor

Image Number 4 for United States Patent #5830879.

The present invention provides a method for inducing reendothelialization of the lining of an injured blood vessel comprising contacting the injured portion of the vessel with nucleic acid encoding an endothelial cell mitogen such as vascular endothelial growth factor (VEGF) operably linked to a promoter to result in expression of the mitogen when delivered to the cells at the site of vascular injury. The resulting reendothelialization of the injured blood vessel inhibits smooth muscle cell proliferation and consequently reduces restenosis. The methods of the present invention may be used to treat any blood vessel injury that results in denuding of the endothelial lining of the vessel wall, including, for example, those injuries resulting from balloon angioplasty and deployment of endovascular stents.

  Recently Added Patents
Bit error mitigation
Safety device and method for electric heating appliances
Methods and apparatus for performing multiple photoresist layer development and etching processes
Zero-copy network and file offload for web and application servers
Vehicle control apparatus
Unified recovery
Method and system for remotely testing a wireless device
  Randomly Featured Patents
Programmable transition time adjustment mechanism
Apparatus and method for precisely positioning an object
Diaphragm game caller with conical inner mount
Washing machine with snubbers for limiting unbalanced load vibration excursions
Separation of 2-methyl-1-butanol from 3-methyl-1-butanol by extractive distillation
Test tube opening hood and process
Desk set coin telephone
Image forming apparatus
Highly-versatile variable-angle bone plate system
Method and apparatus for delay analysis of energy transmitted through a medium