Resources Contact Us Home
Treatment of vascular injury using vascular endothelial growth factor

Image Number 4 for United States Patent #5830879.

The present invention provides a method for inducing reendothelialization of the lining of an injured blood vessel comprising contacting the injured portion of the vessel with nucleic acid encoding an endothelial cell mitogen such as vascular endothelial growth factor (VEGF) operably linked to a promoter to result in expression of the mitogen when delivered to the cells at the site of vascular injury. The resulting reendothelialization of the injured blood vessel inhibits smooth muscle cell proliferation and consequently reduces restenosis. The methods of the present invention may be used to treat any blood vessel injury that results in denuding of the endothelial lining of the vessel wall, including, for example, those injuries resulting from balloon angioplasty and deployment of endovascular stents.

  Recently Added Patents
Generation of interpolated samples for decision based decoding
Managing device functionality during predetermined conditions
Proton conducting electrolytes with cross-linked copolymer additives for use in fuel cells
Radiation protective garment with forced ventilation and method
Organic light emitting display device and method of manufacturing the same
Sound producing apparatus for vehicle
Radio frequency power delivery system
  Randomly Featured Patents
Stable integrands
Method and system of channel estimation
Talking luggage
Lead-free solder alloys
Elastomer stress damper with constructable orifice
Organic compound incinerator
Planetary type speed reducer having compound planets and method of constructing such planets
Recording and/or reproducing device
Time telling educational game
Field installed slotted rod guide and method