Resources Contact Us Home
Treatment of vascular injury using vascular endothelial growth factor

Image Number 4 for United States Patent #5830879.

The present invention provides a method for inducing reendothelialization of the lining of an injured blood vessel comprising contacting the injured portion of the vessel with nucleic acid encoding an endothelial cell mitogen such as vascular endothelial growth factor (VEGF) operably linked to a promoter to result in expression of the mitogen when delivered to the cells at the site of vascular injury. The resulting reendothelialization of the injured blood vessel inhibits smooth muscle cell proliferation and consequently reduces restenosis. The methods of the present invention may be used to treat any blood vessel injury that results in denuding of the endothelial lining of the vessel wall, including, for example, those injuries resulting from balloon angioplasty and deployment of endovascular stents.

  Recently Added Patents
IC layout parsing for multiple masks
Method and system to generate finite state grammars using sample phrases
Radiation protective garment with forced ventilation and method
Dual gate electronic memory cell and device with dual gate electronic memory cells
Computer system for routing package deliveries
Discharge lamp comprising coated electrode
  Randomly Featured Patents
Portion of an electronic mouse
Golf ball having specific spin, moment of inertia, lift, and drag relationship
Autoantigen, pinch
Buffer circuit for semiconductor memory
Obliquity correction scanning using a prism mirror
Information storing, readout and calculation system for use in a system for continuously manufacturing liquid-crystal display elements, and method for producing the same
Illuminated tool organizer apparatus and method
Matching the clock phase of duplicated clock circuits
Image display device