Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Encapsidated recombinant viral nucleic acid and methods of making and using same










Image Number 15 for United States Patent #5817512.

The present invention pertains to a method of encapsidating a recombinant poliovirus nucleic acid to obtain a yield of encapsidated viruses which substantially comprises encapsidated recombinant poliovirus nucleic acid. The method of encapsidating a recombinant poliovirus nucleic acid includes contacting a host cell with a recombinant poliovirus nucleic acid which lacks the nucleotide sequence encoding at least a portion of a protein necessary for encapsidation and an expression vector comprising a nucleic acid which encodes at least a portion of one protein necessary for encapsidation under conditions appropriate for introduction of the recombinant poliovirus nucleic acid and the expression vector into the host cell and obtaining a yield of encapsidated viruses which substantially comprises an encapsidated recombinant poliovirus nucleic acid. A foreign nucleotide sequence is generally substituted for the nucleotide sequence of the poliovirus nucleic acid encoding at least a portion of a protein necessary for encapsidation. The invention further pertains to encapsidated recombinant poliovirus nucleic acids produced by the method of this invention and compositions containing the encapsidated or nonencapsidated recombinant poliovirus nucleic acid containing a foreign nucleotide sequence for use in a method of stimulating an immune response in a subject to the protein encoded by the foreign nucleotide sequence.








 
 
  Recently Added Patents
Reception system including a mechanism countering pulsed interference
Smooth silicon-containing films
Methods, apparatus, and systems for facilitating control communications between disparate devices
Aware manufacturing of integrated circuits
Radio communication devices, information providers, methods for controlling a radio communication device and methods for controlling an information provider
Semiconductor device, method of manufacturing semiconductor device, and electronic apparatus
Portion of a display panel with an unhappy facial expression icon
  Randomly Featured Patents
Sliding rack-mountable shelf for rack-mountable components
System and method for epitaxial deposition of a crystal using a liquid-solvent fluidized-bed mechanism
Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation
Stent fabrication via tubular casting processes
Method of preparing a foaming soluble coffee powder
Apparatus and method for providing mechanically pre-formed conductive leads
Apparatus and method for exploiting reverse short channel effects in transistor devices
Test fluid measurement device and sensitivity calibration method thereof
Dual-pipeline architecture for enhancing the performance of graphics memory
Device for measuring the composition of fluids, in particular the components of exhaust gases from internal combustion engines