Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Encapsidated recombinant viral nucleic acid and methods of making and using same










Image Number 15 for United States Patent #5817512.

The present invention pertains to a method of encapsidating a recombinant poliovirus nucleic acid to obtain a yield of encapsidated viruses which substantially comprises encapsidated recombinant poliovirus nucleic acid. The method of encapsidating a recombinant poliovirus nucleic acid includes contacting a host cell with a recombinant poliovirus nucleic acid which lacks the nucleotide sequence encoding at least a portion of a protein necessary for encapsidation and an expression vector comprising a nucleic acid which encodes at least a portion of one protein necessary for encapsidation under conditions appropriate for introduction of the recombinant poliovirus nucleic acid and the expression vector into the host cell and obtaining a yield of encapsidated viruses which substantially comprises an encapsidated recombinant poliovirus nucleic acid. A foreign nucleotide sequence is generally substituted for the nucleotide sequence of the poliovirus nucleic acid encoding at least a portion of a protein necessary for encapsidation. The invention further pertains to encapsidated recombinant poliovirus nucleic acids produced by the method of this invention and compositions containing the encapsidated or nonencapsidated recombinant poliovirus nucleic acid containing a foreign nucleotide sequence for use in a method of stimulating an immune response in a subject to the protein encoded by the foreign nucleotide sequence.








 
 
  Recently Added Patents
Sensor packages and method of packaging dies of differing sizes
Glove
Battery pack with interchangeable circuit substrates
Advertising apparatus
Method and system for presenting live video from video capture devices on a computer monitor
LED light source lamp having drive circuit arranged in outer periphery of LED light source
Video conference
  Randomly Featured Patents
Electricity generating assembly
Sander shield
Power tool
Navigation system for vehicle
Fastener assembly for truck bed liner
Magnetoresistive structures and fabrication methods
Dynamic, multiple-route navigation apparatus and method for guiding a moving object
Thermostable phytase with 2.1 .ANG. . . . crystal structure
Compositions and methods for the generation of protective immune responses against malaria
Dwell angle control for internal combustion engine ignition system