Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Encapsidated recombinant viral nucleic acid and methods of making and using same










Image Number 15 for United States Patent #5817512.

The present invention pertains to a method of encapsidating a recombinant poliovirus nucleic acid to obtain a yield of encapsidated viruses which substantially comprises encapsidated recombinant poliovirus nucleic acid. The method of encapsidating a recombinant poliovirus nucleic acid includes contacting a host cell with a recombinant poliovirus nucleic acid which lacks the nucleotide sequence encoding at least a portion of a protein necessary for encapsidation and an expression vector comprising a nucleic acid which encodes at least a portion of one protein necessary for encapsidation under conditions appropriate for introduction of the recombinant poliovirus nucleic acid and the expression vector into the host cell and obtaining a yield of encapsidated viruses which substantially comprises an encapsidated recombinant poliovirus nucleic acid. A foreign nucleotide sequence is generally substituted for the nucleotide sequence of the poliovirus nucleic acid encoding at least a portion of a protein necessary for encapsidation. The invention further pertains to encapsidated recombinant poliovirus nucleic acids produced by the method of this invention and compositions containing the encapsidated or nonencapsidated recombinant poliovirus nucleic acid containing a foreign nucleotide sequence for use in a method of stimulating an immune response in a subject to the protein encoded by the foreign nucleotide sequence.








 
 
  Recently Added Patents
Optical fibre sensor assembly
2-deoxy-scyllo-inosose synthase
Set of radiator brackets
Printing system and printing method
Soft decision method and associated signal receiving system
Keyboard and electronic apparatus
Polycrystalline silicon reactor
  Randomly Featured Patents
Transition metal-catalyzed process for addition of amines to carbon-carbon double bonds
Hose with sealing layer, direct-connect assembly including the same and method of manufacturing the same
Bundling rake
Fluid flow control devices
Modular, portable data processing terminal for use in a radio frequency communication network
Silicone resin coating composition especially suited for primerless adhesion to cast acrylics
Apparatus for producing capsules
Spout
Method of effecting random access in a mobile radio system
Interpupillary distance measuring device