Resources Contact Us Home
Browse by: INVENTOR PATENT HOLDER PATENT NUMBER DATE
 
 
Encapsidated recombinant viral nucleic acid and methods of making and using same










Image Number 15 for United States Patent #5817512.

The present invention pertains to a method of encapsidating a recombinant poliovirus nucleic acid to obtain a yield of encapsidated viruses which substantially comprises encapsidated recombinant poliovirus nucleic acid. The method of encapsidating a recombinant poliovirus nucleic acid includes contacting a host cell with a recombinant poliovirus nucleic acid which lacks the nucleotide sequence encoding at least a portion of a protein necessary for encapsidation and an expression vector comprising a nucleic acid which encodes at least a portion of one protein necessary for encapsidation under conditions appropriate for introduction of the recombinant poliovirus nucleic acid and the expression vector into the host cell and obtaining a yield of encapsidated viruses which substantially comprises an encapsidated recombinant poliovirus nucleic acid. A foreign nucleotide sequence is generally substituted for the nucleotide sequence of the poliovirus nucleic acid encoding at least a portion of a protein necessary for encapsidation. The invention further pertains to encapsidated recombinant poliovirus nucleic acids produced by the method of this invention and compositions containing the encapsidated or nonencapsidated recombinant poliovirus nucleic acid containing a foreign nucleotide sequence for use in a method of stimulating an immune response in a subject to the protein encoded by the foreign nucleotide sequence.








 
 
  Recently Added Patents
Electrical stimulation lead, system, and method
Hand sign
Method and apparatus for filter-less class D audio amplifier EMI reduction
Drug comprising as the active ingredient proliferative vector containing survivin promoter
Method and apparatus for connecting to external device
Medicament container
Method for forming a film
  Randomly Featured Patents
Optical disk drive
Turret for winders and unwinders
Vehicle with goods loading/unloading apparatus
Modular portable stage system
Full width metatarsal pad
Method and system for detecting pace pulses
Hair detergent compositions
Thermoplastic rubbers and process for preparing same
Methods of applying a hydrophilic coating to a substrate, and substrates having a hydrophilic coating
Toy figure with motion features